DNA Methylation Concept

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• WNT2promoter methylation in human placenta is associated with low birthweight percentile in the neonate  Journal Articles
• A Bayesian hierarchical model for improving measurement of 5mC and 5hmC levels: Toward revealing associations between phenotypes and methylation states  Journal Articles
• A CGG-Repeat Expansion Mutation inZNF713Causes FRA7A: Association with Autistic Spectrum Disorder in two Families  Journal Articles
• A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis  Journal Articles
• A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci  Journal Articles
• A Scoping Review of Epigenetic Signatures of Diet and Diet-related Metabolites: Insights from Epigenome-Wide Association Studies and Their Implications for Cardiometabolic Health and Diseases.  Journal Articles
• A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes  Journal Articles
• A study of the interactions that stabilize DNA frayed wires  Journal Articles
• Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time  Journal Articles
• Alterations of immune response of non-small cell lung cancer with Azacytidine  Journal Articles
• Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD  Journal Articles
• Assessment of methylation level prediction accuracy in methyl-DNA immunoprecipitation and sodium bisulfite based microarray platforms  Journal Articles
• Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life.  Journal Articles
• Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report  Journal Articles
• Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration: Evidence From the Canadian Longitudinal Study on Aging  Journal Articles
• Association of genomic subtypes of lower-grade gliomas with shape features automatically extracted by a deep learning algorithm  Journal Articles
• Atypical Teratoid Rhabdoid Tumors (ATRTs): The British Columbia's Children's Hospital's Experience, 1986–2006  Journal Articles
• BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes  Journal Articles
• BOB CAT: a Large-Scale Review and Delphi Consensus for Management of Barrett’s Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia  Journal Articles
• Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation  Journal Articles
• Biological embedding of child maltreatment: A systematic review of biomarkers and resilience in children and youth.  Theses
• CHARGE and Kabuki Syndromes: Gene-Specific DNA Methylation Signatures Identify Epigenetic Mechanisms Linking These Clinically Overlapping Conditions  Journal Articles
• CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer  Journal Articles
• Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans  Journal Articles
• Characterizing the Secondary Structure and Identifying Functionally Essential Nucleotides of pH6DZ1, a Fluorescence-Signaling and RNA-Cleaving Deoxyribozyme  Journal Articles
• Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array  Journal Articles
• Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders  Journal Articles
• Clinical features of facioscapulohumeral muscular dystrophy 2  Journal Articles
• Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer  Journal Articles
• Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma  Journal Articles
• Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts  Journal Articles
• Cross-Reactive DNA Microarray Probes Lead to False Discovery of Autosomal Sex-Associated DNA Methylation  Journal Articles
• DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders  Journal Articles
• DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes  Journal Articles
• DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome  Journal Articles
• DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study  Journal Articles
• DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs  Journal Articles
• DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly  Journal Articles
• DNA methylation predicts age and provides insight into exceptional longevity of bats  Journal Articles
• DNA methylation predicts stroke outcome better  Journal Articles
• DNA methylation profiles in adults born at extremely low birth weight  Journal Articles
• DNA methyltransferase inhibitors—state of the art  Journal Articles
• Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas  Journal Articles
• Diagnosis of TET3-Related Beck-Fahrner Syndrome in an Individual With Chorioretinal and Iris Colobomata Using a DNA Methylation Signature.  Journal Articles
• Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions  Journal Articles
• Discovery of Novel Hypermethylated Genes in Prostate Cancer Using Genomic CpG Island Microarrays  Journal Articles
• Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray  Journal Articles
• Draft genome of the globally widespread and invasive Argentine ant ( Linepithema humile )  Journal Articles
• EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines  Journal Articles
• Epigenetic Age and the Risk of Incident Atrial Fibrillation  Journal Articles
• Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*  Journal Articles
• Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.  Journal Articles
• Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells  Journal Articles
• Epigenetic Regulation of Tumor Necrosis Factor Alpha  Journal Articles
• Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging  Journal Articles
• Epigenetic silencing of miR-145-5p contributes to brain metastasis  Journal Articles
• Epigenetics of Sepsis  Journal Articles
• Epigenetics, heritability and longitudinal analysis  Journal Articles
• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy  Journal Articles
• Erasure of DNA methylation in rat fetal germ cells is sex-specific and sensitive to maternal high-fat diet.  Journal Articles
• Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase  Journal Articles
• Evaluation of DNA Methylation Array for Glioma Tumor Profiling and Description of a Novel Epi-Signature to Distinguish IDH1/IDH2 Mutant and Wild-Type Tumors  Journal Articles
• Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders  Journal Articles
• Functional DNA methylation signatures for autism spectrum disorder genomic risk loci: 16p11.2 deletions and CHD8 variants  Journal Articles
• Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR  Journal Articles
• GWAS of biological aging to find longevity genes in schizophrenia.  Journal Articles
• Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway  Journal Articles
• Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis.  Journal Articles
• Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy  Journal Articles
• Genome-wide germline correlates of the epigenetic landscape of prostate cancer  Journal Articles
• Genome-wide host methylation profiling of anal and cervical carcinoma  Journal Articles
• Genome‐wide DNA methylation changes with age in disease‐free human skeletal muscle  Journal Articles
• Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes  Journal Articles
• Genomic and epigenetic evidence for oxytocin receptor deficiency in autism  Journal Articles
• Genomic hallmarks of localized, non-indolent prostate cancer  Journal Articles
• Genomics and epigenomics in pediatric oncology and clinical laboratory genetics  Journal Articles
• Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences  Journal Articles
• Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease  Journal Articles
• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma  Journal Articles
• Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report  Journal Articles
• Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy  Journal Articles
• Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome  Journal Articles
• Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research.  Journal Articles
• Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator  Journal Articles
• Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes  Journal Articles
• Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors  Journal Articles
• Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants  Journal Articles
• Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study  Journal Articles
• Intertumoral Heterogeneity within Medulloblastoma Subgroups  Journal Articles
• Kaiso Represses the Cell Cycle Gene cyclin D1 via Sequence-Specific and Methyl-CpG-Dependent Mechanisms  Journal Articles
• METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors  Journal Articles
• Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi  Journal Articles
• Maternal nutritional history modulates the hepatic IGF–IGFBP axis in adult male rat offspring  Journal Articles
• Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants  Journal Articles
• Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry  Preprints
• Maternal smoking during pregnancy and cord blood DNA methylation: new insight on sex differences and effect modification by maternal folate levels  Journal Articles
• Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma  Journal Articles
• Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso  Journal Articles
• Molecular Classification of Endometrial Cancers Using an Integrative DNA Sequencing Panel.  Conferences
• Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C  Journal Articles
• NSD1 mutations generate a genome-wide DNA methylation signature  Journal Articles
• New insights into DNA methylation signatures: SMARCA2 variants in Nicolaides-Baraitser syndrome  Journal Articles
• O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation Analysis in Glioblastoma Patients.  Chapters
• Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation  Journal Articles
• Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation  Journal Articles
• Pan-urologic cancer genomic subtypes that transcend tissue of origin  Journal Articles
• Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C  Journal Articles
• Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study  Journal Articles
• Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas  Journal Articles
• Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children  Journal Articles
• Prader–Willi syndrome and Tay–Sachs disease in association with mixed maternal uniparental isodisomy and heterodisomy 15 in a girl who also had isochromosome Xq  Journal Articles
• Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma  Journal Articles
• Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.  Journal Articles
• Radiation and the regulatory landscape of neo2-Darwinism  Journal Articles
• Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes  Journal Articles
• Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution  Journal Articles
• Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth  Journal Articles
• Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel  Journal Articles
• Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines  Journal Articles
• Revitalization of Six Abandoned Catalytic DNA Species Reveals a Common Three-way Junction Framework and Diverse Catalytic Cores  Journal Articles
• SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation.  Journal Articles
• SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females  Journal Articles
• Salivary DNA methylation derived estimates of biological aging, cellular frequency and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients.  Journal Articles
• Secondary-Structure Characterization of Two Proficient Kinase Deoxyribozymes  Journal Articles
• Sensitive and Efficient Detection of RB1 Gene Mutations Enhances Care for Families with Retinoblastoma  Journal Articles
• Sequence overlap between autosomal and sex-linked probes on the Illumina HumanMethylation27 microarray  Journal Articles
• Silencing of GSTP1, a Prostate Cancer Prognostic Gene, by the Estrogen Receptor-β and Endothelial Nitric Oxide Synthase Complex  Journal Articles
• Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality  Journal Articles
• Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states  Journal Articles
• TGFβ Programs Central Memory Differentiation inEx Vivo–Stimulated Human T Cells  Journal Articles
• TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma  Journal Articles
• The DNA methylation landscape of advanced prostate cancer  Journal Articles
• The Human Enhancer Blocker CTC-binding Factor Interacts with the Transcription Factor Kaiso  Journal Articles
• The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells  Journal Articles
• The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)  Journal Articles
• The defining DNA methylation signature of Floating-Harbor Syndrome  Journal Articles
• The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance  Journal Articles
• The methylenetetrahydrofolate reductase C677T mutation induces cell‐specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site‐specific cancer risk modification  Journal Articles
• The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides  Journal Articles
• The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study  Journal Articles
• The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review  Journal Articles
• Thyroid hormone links environmental signals to DNA methylation  Journal Articles
• Toll-like Receptor 9, CpG DNA and Innate Immunity  Journal Articles
• Understanding the clinical implication of mismatch repair deficiency in endometrioid endometrial cancer through a prospective study  Journal Articles
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Journal Articles