Journal article
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Abstract
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three …
Authors
Torchia J; Golbourn B; Feng S; Ho C; Sin-Chan P; Vasiljevic A; Norman JD; Guilhamon P; Garzia L; Agamez NR
Journal
Cancer Cell, Vol. 30, No. 6, pp. 891–908
Publisher
Elsevier
Publication Date
December 2016
DOI
10.1016/j.ccell.2016.11.003
ISSN
1535-6108