Journal article
DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes
Abstract
BackgroundMany CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal population whereas PhenoAge and GrimAge use surrogate markers associated with mortality to estimate biological age and its departure from chronological age. …
Authors
Roshandel D; Chen Z; Canty AJ; Bull SB; Natarajan R; Paterson AD
Journal
Clinical Epigenetics, Vol. 12, No. 1,
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1186/s13148-020-00840-6
ISSN
1868-7075