Journal article
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
Abstract
OBJECTIVES: Epigenetic alterations are an important regulator of gene expression in health and disease; however, epigenetic data in sepsis are lacking. To demonstrate proof of concept and estimate effect size, we performed the first epigenome-wide methylation analysis of whole blood DNA samples from a cohort of septic and nonseptic critically ill patients. DESIGN: A nested case-control study using genomic DNA isolated from whole blood from …
Authors
Binnie A; Walsh CJ; Hu P; Dwivedi DJ; Fox-Robichaud A; Liaw PC; Tsang JLY; Batt J; Carrasqueiro G; Gupta S
Journal
Crit Care Med, Vol. 48, No. 2, pp. 142–150
Publication Date
February 2020
DOI
10.1097/CCM.0000000000004097