Journal article
Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report
Abstract
Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is considered one of the mechanisms underlying the development of major depressive disorder (MDD), but the exact nature of this dysfunction is unknown. We investigated the relationship between hypothalamus volume (HV) and blood-derived DNA methylation in MDD. We obtained brain MRI, clinical and molecular data from 181 unmedicated MDD and 90 healthy control (HC) participants. MDD …
Authors
Suh JS; Fiori LM; Ali M; Harkness KL; Ramonas M; Minuzzi L; Hassel S; Strother SC; Zamyadi M; Arnott SR
Journal
Psychoneuroendocrinology, Vol. 132, ,
Publisher
Elsevier
Publication Date
October 2021
DOI
10.1016/j.psyneuen.2021.105348
ISSN
0306-4530