Journal article
Genomic hallmarks of localized, non-indolent prostate cancer
Abstract
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and 277 additional whole-exome sequences from localized, non-indolent prostate tumours with similar clinical risk profiles, and carried out RNA and methylation analyses in a subset. These tumours had a paucity of clinically actionable …
Authors
Fraser M; Sabelnykova VY; Yamaguchi TN; Heisler LE; Livingstone J; Huang V; Shiah Y-J; Yousif F; Lin X; Masella AP
Journal
Nature, Vol. 541, No. 7637, pp. 359–364
Publisher
Springer Nature
Publication Date
1 2017
DOI
10.1038/nature20788
ISSN
0028-0836