Journal article
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
Abstract
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Here we demonstrate that PFA ependymomas are maintained under hypoxia, associated with restricted availability of specific metabolites to diminish histone methylation, and increase histone …
Authors
Michealraj KA; Kumar SA; Kim LJY; Cavalli FMG; Przelicki D; Wojcik JB; Delaidelli A; Bajic A; Saulnier O; MacLeod G
Journal
Cell, Vol. 181, No. 6, pp. 1329–1345.e24
Publisher
Elsevier
Publication Date
June 2020
DOI
10.1016/j.cell.2020.04.047
ISSN
0092-8674