Journal article
Genome-wide germline correlates of the epigenetic landscape of prostate cancer
Abstract
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms on the somatic epigenome of 589 localized prostate tumors. Predisposition risk loci influence a tumor’s epigenome, uncovering a mechanism for cancer susceptibility. We identified and validated 1,178 loci associated with altered …
Authors
Houlahan KE; Shiah Y-J; Gusev A; Yuan J; Ahmed M; Shetty A; Ramanand SG; Yao CQ; Bell C; O’Connor E
Journal
Nature Medicine, Vol. 25, No. 10, pp. 1615–1626
Publisher
Springer Nature
Publication Date
October 2019
DOI
10.1038/s41591-019-0579-z
ISSN
1078-8956