Journal article
METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors
Abstract
BackgroundThymic epithelial tumors (TETs) are rare neoplasms, originating from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined, and a deeper molecular characterization could result in a relevant advance in their management, greatly improving diagnosis, prognosis and treatment choice. Deregulation of N6-methyladenosine (m6A) RNA modification, catalyzed by the METTL3/METTL14 methyltransferase …
Authors
Iaiza A; Tito C; Ianniello Z; Ganci F; Laquintana V; Gallo E; Sacconi A; Masciarelli S; De Angelis L; Aversa S
Journal
Clinical Epigenetics, Vol. 13, No. 1,
Publisher
Springer Nature
Publication Date
December 2021
DOI
10.1186/s13148-021-01159-6
ISSN
1868-7075