Journal article
The DNA methylation landscape of advanced prostate cancer
Abstract
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches. Notably, we observed that 22% of …
Authors
Zhao SG; Chen WS; Li H; Foye A; Zhang M; Sjöström M; Aggarwal R; Playdle D; Liao A; Alumkal JJ
Journal
Nature Genetics, Vol. 52, No. 8, pp. 778–789
Publisher
Springer Nature
Publication Date
8 2020
DOI
10.1038/s41588-020-0648-8
ISSN
1061-4036