Journal article
Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes
Abstract
The mechanism by which radiation-induced genomic instability is initiated, propagated and effected is currently under intense scrutiny. We have investigated the potential role of altered genomic methylation patterns in the cellular response to irradiation and have found evidence for widespread dysregulation of CpG methylation persisting up to 20 population doublings post-irradiation. Similar effects are seen with cells treated with medium from …
Authors
Kaup S; Grandjean V; Mukherjee R; Kapoor A; Keyes E; Seymour CB; Mothersill CE; Schofield PN
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 597, No. 1-2, pp. 87–97
Publisher
Elsevier
Publication Date
May 2006
DOI
10.1016/j.mrfmmm.2005.06.032
ISSN
0027-5107