Journal article
A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci
Abstract
CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromosomal DNA by their frequent lack of cytosine methylation, we devised a CGI enrichment method based on nonmethylated CpG affinity chromatography. The resulting library was sequenced to define a novel human blood CGI set that includes many that are not detected by current …
Authors
Illingworth R; Kerr A; DeSousa D; Jørgensen H; Ellis P; Stalker J; Jackson D; Clee C; Plumb R; Rogers J
Journal
PLOS Biology, Vol. 6, No. 1,
Publisher
Public Library of Science (PLoS)
Publication Date
1 2008
DOI
10.1371/journal.pbio.0060022
ISSN
1544-9173