Karen Mossman - McMaster Experts

Affiliations

McMaster University,
Faculty of Health Sciences, McMaster University
Member, McMaster Immunology Research Centre (MIRC), Faculty of Health Sciences
Member, Michael G. DeGroote Institute for Infectious Disease Research (IIDR), Faculty of Health Sciences
Member, Centre for Discovery in Cancer Research (CDCR), Faculty of Health Sciences
Associate Member, Biochemistry & Biomedical Sciences, Faculty of Health Sciences
Professor, Medicine, Faculty of Health Sciences
Professor, Medicine, McMaster University

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selected scholarly activity

chapters
- Innate Antiviral Immunity Methods and Protocols Preface. Methods in molecular biology (Clifton, N.J.). V-V. 2017
- Mechanisms of Subversion of Type I Interferon Responses by Alphaherpesviruses. 219-235. 2011
- The Antiviral Effects of Extracellular dsRNA. 1-18. 2011
- Analysis of Anti-Interferon Properties of the Herpes Simplex Virus Type I ICP0 Protein. Methods in Molecular Medicine. 195-205. 2005
- Herpes Simplex Type 1 for Use in Cancer Gene Therapy: Looking Backward to Move Forward
conferences
- CELLULAR DETECTION OF MEMBRANE FUSION MODULATES THE IFN-I RESPONSE TO ENVELOPED VIRUS. Cytokine. 86-86. 2016
- ELUCIDATING THE DIFFERENTIAL INDUCTION OF TYPE I INTERFERON FOLLOWING CLASS A SCAVENGER RECEPTOR UPTAKE OF EXTRACELLULAR RNA AND DNA. Cytokine. 92-92. 2016
- ID: 60. Cytokine. 75-76. 2015
- S-6. Cytokine. 242-242. 2013
- Type I interferon induced by lymphotoxin-beta receptor signaling on dendritic cell is crucial for CD8 T cell infiltration into effector site by modulating the expression of tissue specific adhesion molecule VLA4. Journal of Immunology. 2013
- P130 IRF9 binds to the interferon-B promoter and mediates interferon production in the absence of IRF3 in response to double-stranded RNA. Cytokine. 561-561. 2012
- Characterization of Bovine Herpesvirus Type 1 as a Novel Oncolytic Virus. In Vitro Cellular and Developmental Biology - Animal. 10-11. 2012
- Characterization of Bovine Herpesvirus Type 1 as a Novel Oncolytic Virus. In Vitro Cellular and Developmental Biology - Animal. 32-32. 2012
- PS2-018. Novel responses to dsRNA recognition in the absence of IRF3 and the type I interferon system. Cytokine. 68-68. 2011
- CS2-4 Novel pathways involved in extracellular double-stranded RNA recognition, entry and signaling. Cytokine. 7-8. 2010
- PS2-79 Virus particle entry induces an interferon-independent antiviral response that is mediated by reactive oxygen species. Cytokine. 67-67. 2010
- Targeting Peroxisome Proliferator Activated Receptor-Gamma May Be Important For Attenuating Exacerbated Inflammatory Responses To Influenza A Virus In Smoke-Exposed Mice. American Journal of Respiratory and Critical Care Medicine. 2010
- Treating Viral Exacerbations Of COPD With Steroids: Lessons Learned From Animal Models Of Cigarette Smoke Exposure And Influenza A Virus Infection. American Journal of Respiratory and Critical Care Medicine. 2010
- Class A Scavenger Receptors as Innate Antiviral Sensors. In Vitro Cellular and Developmental Biology - Animal. S17-S18. 2010
- 295 Membrane fusion activates interferon regulatory factor 3. Cytokine. 313-313. 2008
- Inactivation of viruses with a femtosecond laser via impulsive stimulated Raman scattering. Proceedings of SPIE - The International Society for Optical Engineering. 2008
- Membrane fusion mediates the IRF3-dependent IFN-independent antiviral response following virus entry. Journal of Interferon and Cytokine Research. 691-691. 2007
- 138 Distinct Functional Motifs Within the IL-17 Receptor Regulate Signal Transduction and Target Gene Expression. Cytokine. 38-38. 2007
- Signaling motifs in the IL-17 receptor (94.2). Journal of Immunology. S170-S171. 2007
- Interruption of cytokine networks by poxviruses: lessons from myxoma virus. Journal of Leukocyte Biology. 731-738. 1995
- POXVIRUSES ENCODE SECRETED PROTEINS WHICH BIND AND INHIBIT GAMMA-INTERFERON. Journal of Cellular Biochemistry. 79-79. 1993
journal articles
- SARS-CoV-2 pathogenesis in an angiotensin II–induced heart-on-a-chip disease model and extracellular vesicle screening. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403581121. 2024
- A Significant Contribution of the Classical Pathway of Complement in SARS-CoV-2 Neutralization of Convalescent and Vaccinee Sera. Journal of Immunology. 212:1922-1931. 2024
- Fatal attractions that trigger inflammation and drive atherosclerotic disease. European Journal of Clinical Investigation. 54:e14169. 2024
- Pyroptosis activates conventional type I dendritic cells to mediate the priming of highly functional anticancer T cells. Journal for ImmunoTherapy of Cancer. 12:e006781-e006781. 2024
- Immunological features of bats: resistance and tolerance to emerging viruses. Trends in Immunology. 45:198-210. 2024
- ASK1 inhibitors are potential pan-antiviral drugs, which dampen replication of diverse viruses including SARS-CoV2. Antiviral Research. 220:105736-105736. 2023
- Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerging Infectious Diseases. 29:1386-1396. 2023
- Detection of Large Genomic RNA via DNAzyme‐Mediated RNA Cleavage and Rolling Circle Amplification: SARS‐CoV‐2 as a Model. Chemistry - A European Journal. 29:e202300075. 2023
- Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1. Journal for ImmunoTherapy of Cancer. 11:e006408-e006408. 2023
- Oncolytic BHV-1 Is Sufficient to Induce Immunogenic Cell Death and Synergizes with Low-Dose Chemotherapy to Dampen Immunosuppressive T Regulatory Cells. Cancers. 15:1295-1295. 2023
- Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2. Viruses. 15:496-496. 2023
- Differential Cellular Sensing of Fusion from within and Fusion from without during Virus Infection. Viruses. 15:301-301. 2023
- Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors. Vaccine Reports. 9:e12744-e12744. 2023
- Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer. Journal of the American Chemical Society. 144:23465-23473. 2022
- Laying the foundation for single-cell studies in bats. Immunity. 55:1974-1977. 2022
- Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2 2022
- Human coronaviruses disassemble processing bodies. PLoS Pathogens. 18:e1010724-e1010724. 2022
- Visualizing Early HCoV-229E Viral Infection Events Using Correlative 2D Light and 3D Electron Microscopy Techniques. Microscopy and Microanalysis. 28:1528-1530. 2022
- Utilization of FIB–SEM nanotomography to visualize early HCoV-229E virus-mediated endocytosis nanoscale interactions. Acta Crystallographica Section A: Foundations of Crystallography. 78:a319-a319. 2022
- Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways. iScience. 25:104614-104614. 2022
- IFNAR blockade synergizes with oncolytic VSV to prevent virus-mediated PD-L1 expression and promote antitumor T cell activity. Molecular Therapy - Oncolytics. 25:16-30. 2022
- Covalent Immune Proximity-Induction Strategy Using SuFEx-Engineered Bifunctional Viral Peptides. ACS Chemical Biology. 17:1269-1281. 2022
- Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters. npj Vaccines. 7:49. 2022
- Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation. Lab on a Chip. 22:1171-1186. 2022
- A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern. Chemistry - A European Journal. 28:e202200078. 2022
- A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern. Chemistry - A European Journal. 28:e202200524. 2022
- Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern (Chem. Eur. J. 15/2022). Chemistry - A European Journal. 28:e202200523. 2022
- BCG vaccination provides protection against IAV but not SARS-CoV-2. Cell Reports. 38:110502-110502. 2022
- Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell. 185:896-915.e19. 2022
- A Combination of Chemotherapy and Oncolytic Virotherapy Sensitizes Colorectal Adenocarcinoma to Immune Checkpoint Inhibitors in a cDC1-Dependent Manner. International Journal of Molecular Sciences. 23:1754-1754. 2022
- Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B. Science Advances. 8:eabj9815. 2022
- Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells. Frontiers in Immunology. 13:859749. 2022
- The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation. Viruses. 14:60-60. 2021
- Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2. Cell and Bioscience. 11:202. 2021
- Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer. Cancers. 13:5590-5590. 2021
- High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva. Angewandte Chemie International Edition. 60:24266-24274. 2021
- High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva. Angewandte Chemie International Edition. 133:24468-24476. 2021
- Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome. Cell Reports. 37:109892-109892. 2021
- Molecular Determinants of SARS-CoV-2 Variants. Trends in Microbiology. 29:871-873. 2021
- AHR signaling is induced by infection with coronaviruses. Nature Communications. 12:5148. 2021
- Evolutionary trajectory of SARS-CoV-2 and emerging variants. Virology Journal. 18:166. 2021
- Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library. Nucleic Acids Research (NAR). 49:7267-7279. 2021
- Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells. Communications Biology. 4:859. 2021
- Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways 2021
- Detecting single cell interferon-beta production using a fluorescent reporter telomerase-immortalized human fibroblast cell line. STAR Protocols. 2:100436-100436. 2021
- Mechanisms of PD-L1 Regulation in Malignant and Virus-Infected Cells. International Journal of Molecular Sciences. 22:4893-4893. 2021
- Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer. International Journal of Molecular Sciences. 22:4843-4843. 2021
- Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. iScience. 24:102477-102477. 2021
- Unraveling the Zoonotic Origin and Transmission of SARS-CoV-2. Trends in Ecology and Evolution. 36:180-184. 2021
- Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy. Cancers. 13:806-806. 2021
- Zooanthroponotic potential of SARS-CoV-2 and implications of reintroduction into human populations. Cell Host and Microbe. 29:160-164. 2021
- Open drug discovery of anti-virals critical for Canada's pandemic strategy. Facets. 5:1019-1036. 2020
- Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus. Journal of General Virology. 101:1251-1260. 2020
- Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection. iScience. 23:101864-101864. 2020
- De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors. Communications Biology. 3:645. 2020
- Bat Influenza Viruses: Making a Double Agent of MHC Class II. Trends in Microbiology. 28:703-706. 2020
- Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. European Respiratory Journal. 56:2001123-2001123. 2020
- Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerging Infectious Diseases. 26:2054-2063. 2020
- A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture. Viruses. 12:895-895. 2020
- Correction: Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer. 8:e000337corr1-e000337corr1. 2020
- Hypoxia-Driven Immune Escape in the Tumor Microenvironment. Cells. 9:992-992. 2020
- Seroprevalence in Bats and Detection of Borrelia burgdorferi in Bat Ectoparasites. Microorganisms. 8:440-440. 2020
- Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer. 8:e000337-e000337. 2020
- Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection. iScience. 23:100958-100958. 2020
- Genetic modification of oncolytic viruses to enhance antitumor immunity. Methods in Enzymology. 635:231-250. 2020
- Novel Insights Into Immune Systems of Bats. Frontiers in Immunology. 11:26. 2020
- Open drug discovery of anti-virals critical for Canada’s pandemic strategy. Facets. 5:1019-1036. 2020
- IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling. Cytokine. 124:154439-154439. 2019
- Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus. Current Clinical Microbiology Reports. 6:139-147. 2019
- Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?. OncoImmunology. 8:e1581528-e1581528. 2019
- Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer. Scientific Reports. 9:1865. 2019
- Bats and Coronaviruses. Viruses. 11:41-41. 2019
- Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors. OncoImmunology. 7:e1503032-e1503032. 2018
- Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors. Immunology and Cell Biology. 96:922-934. 2018
- Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLoS Pathogens. 14:e1007264-e1007264. 2018
- Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies. Journal of Immunology. 200:450-458. 2018
- Commentary: Phyllostomid bat microbiome composition is associated to host phylogeny and feeding strategies. Frontiers in Microbiology. 9:2863. 2018
- Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection. Journal of Experimental Medicine (JEM). 214:1153-1167. 2017
- Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition. Journal of Innate Immunity. 9:343-358. 2017
- Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival. Frontiers in Immunology. 8:1039. 2017
- USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. 18:54-63. 2017
- Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. 17:1479-1479. 2016
- USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. 17:1479-1479. 2016
- The Importance of Physiologically Relevant Cell Lines for Studying Virus–Host Interactions. Viruses. 8:297-297. 2016
- Genome-wide lentiviral shRNA screen identifies serine/arginine-rich splicing factor 2 as a determinant of oncolytic virus activity in breast cancer cells. Oncogene. 35:2465-2474. 2016
- S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3. Nature Immunology. 17:514-522. 2016
- Membrane Perturbation-Associated Ca ²⁺ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry. Journal of Virology. 90:3018-3027. 2016
- Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nature Immunology. 17:65-75. 2016
- Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments. Frontiers in Immunology. 7:498. 2016
- A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology. Journal of Immunology. 195:4650-4659. 2015
- Methods related to molecular virology. ImmunoMethods. 90:1-2. 2015
- Class A Scavenger Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity. Journal of Immunology. 195:3858-3865. 2015
- Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at thetrans-Golgi Network To Promote Virus Replication. Journal of Virology. 89:9841-9852. 2015
- Oncolytic bovine herpesvirus type 1 as a broad spectrum cancer therapeutic. Current Opinion in Virology. 13:11-16. 2015
- The Role of Oncolytic Virus Immunotherapies to Subvert Cancer Immune Evasion. Future Oncology. 11:675-689. 2015
- HSV Cheats the Executioner. Cell Host and Microbe. 17:148-151. 2015
- Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma. Molecular Therapy - Oncolytics. 2:15004-15004. 2015
- The Role of Palmitoylation for Protein Recruitment to the Inner Membrane Complex of the Malaria Parasite. Journal of Biological Chemistry. 290:1712-1728. 2015
- Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene. PLoS ONE. 10:e0131129-e0131129. 2015
- Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses. Journal of Visualized Experiments. e52232. 2014
- Danger, diversity and priming in innate antiviral immunity. Cytokine and Growth Factor Reviews. 25:525-531. 2014
- Consensus guidelines for the detection of immunogenic cell death. OncoImmunology. 3:e955691-e955691. 2014
- Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 111:E3206-E3213. 2014
- Identifying Roadblocks to sUccessful Oncolytic Virotherapy: What are they and how do we Approach Them?. Future Virology. 9:695-697. 2014
- Novel Roles of Cytoplasmic ICP0: Proteasome-Independent Functions of the RING Finger Are Required To Block Interferon-Stimulated Gene Production but Not To Promote Viral Replication. Journal of Virology. 88:8091-8101. 2014
- Permissiveness of Human Cancer Cells to Oncolytic Bovine Herpesvirus 1 Is Mediated in Part by KRAS Activity. Journal of Virology. 88:6885-6895. 2014
- Extracellular dsRNA: Its Function and Mechanism of Cellular Uptake. Journal of Interferon and Cytokine Research. 34:419-426. 2014
- Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies. Molecular Therapy. 22:251-256. 2014
- Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy. Molecular Therapy. 22:123-131. 2014
- Rewiring cancer cell death to enhance oncolytic viro-immunotherapy. OncoImmunology. 2:e27138-e27138. 2013
- Combining Oncolytic HSV-1 with Immunogenic Cell Death-Inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy. Cancer immunology research. 1:309-319. 2013
- HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium. Journal of Immunology. 191:4246-4258. 2013
- Novel paradigms of innate immune sensing of viral infections. Cytokine. 63:219-224. 2013
- Proinflammatory Cytokines and Chemokines - But not Interferon-β - Produced in Response to HSV-2 in Primary Human Genital Epithelial Cells are Associated with Viral Replication and the Presence of the Virion Host Shutoff Protein. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. 70:199-212. 2013
- Oncolytic bovine herpesvirus type 1 infects and kills breast tumor cells and breast cancer-initiating cells irrespective of tumor subtype. Cancer Gene Therapy. 20:282-289. 2013
- Recent advances in understanding viral evasion of type I interferon. Immunology. 138:190-197. 2013
- MARCO Is Required for TLR2- and Nod2-Mediated Responses to Streptococcus pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx. Journal of Immunology. 190:250-258. 2013
- The Herpes Simplex Virus 1-Encoded Envelope Glycoprotein B Activates NF-κB through the Toll-Like Receptor 2 and MyD88/TRAF6-Dependent Signaling Pathway. PLoS ONE. 8:e54586-e54586. 2013
- Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmunity Reviews. 11:863-872. 2012
- Adenovirus Evasion of Interferon-Mediated Innate Immunity by Direct Antagonism of a Cellular Histone Posttranslational Modification. Cell Host and Microbe. 11:597-606. 2012
- Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5. Journal of Virology. 86:3528-3540. 2012
- Comparative functional evaluation of immunocompetent mouse breast cancer models established from PyMT-tumors using small animal PET with [(18)F]FDG and [(18)F]FLT.. American Journal of Nuclear Medicine and Molecular Imaging. 2:88-98. 2012
- The Nitric Oxide Pathway Provides Innate Antiviral Protection in Conjunction with the Type I Interferon Pathway in Fibroblasts. PLoS ONE. 7:e31688-e31688. 2012
- Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3. Journal of Virology. 85:11079-11089. 2011
- Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response. Journal of Virology. 85:10926-10931. 2011
- Methods related to molecular virology. ImmunoMethods. 55:107-108. 2011
- A critical role for IL‐15 in TLR‐mediated innate antiviral immunity against genital HSV‐2 infection. Immunology and Cell Biology. 89:663-669. 2011
- Retroviral expression of MIR2 decreases both surface MHC class I and the alloimmune CTL response. Journal of tissue engineering and regenerative medicine. 5:520-528. 2011
- IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-Infected Dendritic Cells. Cancer Research. 71:2497-2506. 2011
- Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy. Molecular Therapy. 19:335-344. 2011
- Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection. PLoS ONE. 5:e13251-e13251. 2010
- Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts Is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-Specific MicroRNA 122. Journal of Virology. 84:9170-9180. 2010
- Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors. Molecular Therapy. 18:1422-1429. 2010
- Bovine herpesvirus type 1 as a novel oncolytic virus. Cancer Gene Therapy. 17:344-355. 2010
- DSRNA and the Innate Antiviral Immune Response. Future Virology. 5:325-341. 2010
- Cellular Localization of the Herpes Simplex Virus ICP0 Protein Dictates Its Ability to Block IRF3-Mediated Innate Immune Responses. PLoS ONE. 5:e10428-e10428. 2010
- An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses. PLoS Pathogens. 6:e1000829-e1000829. 2010
- Innate and Adaptive Immune Responses to Herpes Simplex Virus. Viruses. 1:979-1002. 2009
- Long Double-Stranded RNA Induces an Antiviral Response Independent of IFN Regulatory Factor 3, IFN-β Promoter Stimulator 1, and IFN. Journal of Immunology. 183:6545-6553. 2009
- Cell Fusion-Induced Activation of Interferon-Stimulated Genes Is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed between Permissive and Restrictive Cells. Journal of Virology. 83:8976-8979. 2009
- Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs. Molecular Immunology. 46:3108-3116. 2009
- Mechanisms Employed by Herpes Simplex Virus 1 to Inhibit the Interferon Response. Journal of Interferon and Cytokine Research. 29:599-608. 2009
- PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses. Gene Therapy. 16:1077-1087. 2009
- Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry. Journal of Virology. 83:4013-4022. 2009
- Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-β production. Molecular Immunology. 46:821-829. 2009
- Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production. Molecular Immunology. 46:393-399. 2009
- FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling. PLoS Pathogens. 4:e1000233-e1000233. 2008
- Restoration of Vitamin C Synthesis in Transgenic Gulo^−/− Mice by Helper-Dependent Adenovirus-Based Expression of Gulonolactone Oxidase. Human gene therapy. Clinical development. 19:1349-1358. 2008
- Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand. Journal of Immunology. 181:6702-6706. 2008
- Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells. Journal of Interferon and Cytokine Research. 28:167-179. 2008
- Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke. Journal of Leukocyte Biology. 83:774-784. 2008
- Antigen Presentation by Exosomes Released from Peptide-Pulsed Dendritic Cells Is not Suppressed by the Presence of Active CTL. Journal of Immunology. 179:5024-5032. 2007
- Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proceedings of the National Academy of Sciences of the United States of America. 104:7506-7511. 2007
- The IFN-Independent Response to Virus Particle Entry Provides a First Line of Antiviral Defense That Is Independent of TLRs and Retinoic Acid-Inducible Gene I. Journal of Immunology. 177:8008-8016. 2006
- Induction of Innate Immunity against Herpes Simplex Virus Type 2 Infection via Local Delivery of Toll-Like Receptor Ligands Correlates with Beta Interferon Production. Journal of Virology. 80:9943-9950. 2006
- ICP0 Prevents RNase L-Independent rRNA Cleavage in Herpes Simplex Virus Type 1-Infected Cells. Journal of Virology. 80:218-225. 2006
- Identification of a Novel Pathway Essential for the Immediate-Early, Interferon-Independent Antiviral Response to Enveloped Virions. Journal of Virology. 80:226-235. 2006
- Functional inaccessibility of quiescent herpes simplex virus genomes. Virology Journal. 2:85. 2005
- The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. Molecular Therapy. 12:1101-1110. 2005
- Herpesviruses and the Innate Immune Response. Viral Immunology. 18:267-281. 2005
- Analysis of Anti-Interferon Properties of the Herpes Simplex Virus Type I ICP0 Protein. Methods in Molecular Medicine. 116:195-205. 2005
- Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication. Journal of Virology. 78:1706-1717. 2004
- The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes. Journal of Virology. 78:1675-1684. 2004
- Activation and Inhibition of Virus and Interferon: The Herpesvirus Story. Viral Immunology. 15:3-15. 2002
- Herpes Simplex Virus ICP0 and ICP34.5 Counteract Distinct Interferon-Induced Barriers to Virus Replication. Journal of Virology. 76:1995-1998. 2002
- Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response. Journal of Virology. 75:750-758. 2001
- Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event. Journal of Virology. 74:6287-6299. 2000
- Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon. Journal of Virology. 74:2052-2056. 2000
- Truncation of the C-Terminal Acidic Transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0. Journal of Virology. 73:9726-9733. 1999
- The Myxoma Virus M-T4 Gene Encodes a Novel RDEL-Containing Protein That Is Retained within the Endoplasmic Reticulum and Is Important for the Productive Infection of Lymphocytes. Virology. 239:360-377. 1997
- The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines. Journal of Virology. 71:4356-4363. 1997
- Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits. Journal of Virology. 70:4394-4410. 1996
- Myxoma Virus M-T7, a Secreted Homolog of the Interferon-γ Receptor, Is a Critical Virulence Factor for the Development of Myxomatosis in European Rabbits. Virology. 215:17-30. 1996
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- The Myxoma Virus-soluble Interferon- γ Receptor Homolog, M-T7, Inhibits Interferon- γ in a Species-specific Manner. Journal of Biological Chemistry. 270:3031-3038. 1995
- Myxoma virus and shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability. Virology. 206:572-582. 1995
- Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus. Science. 258:1369-1372. 1992
preprints