Journal article
Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways
Abstract
The angiotensin-converting enzyme 2 (ACE2) protein is a key catalytic regulator of the renin-angiotensin system (RAS), involved in fluid homeostasis and blood pressure modulation. ACE2 also serves as a cell-surface receptor for some coronaviruses such as SARS-CoV and SARS-CoV-2. Improved characterization of ACE2 regulation may help us understand the effects of pre-existing conditions on COVID-19 incidence, as well as pathogenic dysregulation …
Authors
Richard D; Muthuirulan P; Aguiar J; Doxey AC; Banerjee A; Mossman K; Hirota J; Capellini TD
Journal
iScience, Vol. 25, No. 7,
Publisher
Elsevier
Publication Date
July 2022
DOI
10.1016/j.isci.2022.104614
ISSN
2589-0042