Journal article
dsRNA and the innate antiviral immune response
Abstract
Innate immunity is the first line of defense against viral infections. It is based on a mechanism of sensing pathogen-associated molecular patterns through host germline-encoded pattern recognition receptors. dsRNA is arguably the most important viral pathogen-associated molecular pattern due to its expression by almost all viruses at some point during their replicative cycle. Viral dsRNA has been studied for over 55 years, first as a toxin, …
Authors
DeWitte-Orr SJ; Mossman KL
Journal
Future Virology, Vol. 5, No. 3, pp. 325–341
Publisher
Taylor & Francis
Publication Date
May 2010
DOI
10.2217/fvl.10.18
ISSN
1746-0794