Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation Journal Articles uri icon

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abstract

  • Microfluidic polymeric blood vessel captures the adverse effects of SARS-CoV-2 on vasculature and enables identification of a therapeutic peptide that abolished virus induced cytokine storm orchestrated by the immune cells.

authors

  • Lu, Rick Xing Ze
  • Lai, Benjamin Fook Lun
  • Rafatian, Naimeh
  • Gustafson, Dakota
  • Campbell, Scott B
  • Banerjee, Arinjay
  • Kozak, Robert
  • Mossman, Karen
  • Mubareka, Samira
  • Howe, Kathryn L
  • Fish, Jason E
  • Radisic, Milica

publication date

  • March 15, 2022