Journal article
Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection
Abstract
Compared with other mammals, bats harbor more zoonotic viruses per species and do not demonstrate signs of disease on infection with these viruses. To counteract infections with viruses, bats have evolved enhanced mechanisms to limit virus replication and immunopathology. However, molecular and cellular drivers of antiviral responses in bats largely remain an enigma. In this study, we demonstrate that a serine residue in IRF3 is positively …
Authors
Banerjee A; Zhang X; Yip A; Schulz KS; Irving AT; Bowdish D; Golding B; Wang L-F; Mossman K
Journal
iScience, Vol. 23, No. 3,
Publisher
Elsevier
Publication Date
3 2020
DOI
10.1016/j.isci.2020.100958
ISSN
2589-0042