Journal article
Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response
Abstract
We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein. Membrane disturbances during FAST protein-mediated …
Authors
Noyce RS; Taylor K; Ciechonska M; Collins SE; Duncan R; Mossman KL
Journal
Journal of Virology, Vol. 85, No. 20, pp. 10926–10931
Publisher
American Society for Microbiology
Publication Date
October 15, 2011
DOI
10.1128/jvi.00862-11
ISSN
0022-538X