Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus Journal Articles

abstract

• Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

authors

• Upton, Chris
• Mossman, Karen
• McFadden, Grant

status

• published 

publication date

• November 20, 1992

has subject area

• Amino Acid Sequence (MeSH)
• Animals (MeSH)
• Cells, Cultured (MeSH)
• Cloning, Molecular (MeSH)
• General Science & Technology (Science Metrix)
• Genes, Viral (MeSH)
• In Vitro Techniques (MeSH)
• Interferon-gamma (MeSH)
• Molecular Sequence Data (MeSH)
• Myxoma virus (MeSH)
• Protein Binding (MeSH)
• Rabbits (MeSH)
• Receptors, Interferon (MeSH)
• Restriction Mapping (MeSH)
• Sequence Alignment (MeSH)
• Sequence Homology, Amino Acid (MeSH)
• Viral Interference (MeSH)
• Viral Proteins (MeSH)
• Viral Structural Proteins (MeSH)

published in

• Science  Journal

keywords

• Amino Acid Sequence
• Animals
• Cells, Cultured
• Cloning, Molecular
• Genes, Viral
• In Vitro Techniques
• Interferon-gamma
• Molecular Sequence Data
• Myxoma virus
• Protein Binding
• Rabbits
• Receptors, Interferon
• Restriction Mapping
• Sequence Alignment
• Sequence Homology, Amino Acid
• Viral Interference
• Viral Proteins
• Viral Structural Proteins

Digital Object Identifier (DOI)

• 10.1126/science.1455233

PubMed ID

• 1455233

start page

• 1369

end page

• 1372

volume

• 258

issue

• 5086