Journal article
Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production
Abstract
The innate cellular response to virus particle entry in non-immune cells requires the transcriptional activity of interferon regulatory factor 3 (IRF-3), but not production of type I interferon (IFN). Here, we characterize the IFN-independent innate cellular response to virus-derived stimuli in Vero cells, a monkey kidney epithelial cell line deficient for IFN production. We provide evidence that Vero cells are deficient in their ability to …
Authors
Chew T; Noyce R; Collins SE; Hancock MH; Mossman KL
Journal
Molecular Immunology, Vol. 46, No. 3, pp. 393–399
Publisher
Elsevier
Publication Date
January 2009
DOI
10.1016/j.molimm.2008.10.010
ISSN
0161-5890