Tumor Suppressor Protein p53 Concept

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• Id2gene is a transcriptional target of the protein complex mutant p53/E2F1  Journal Articles
• p53 Arg72Pro and MDM2 T309G Polymorphisms, Histology, and Esophageal Cancer Prognosis  Journal Articles
• AMPK β1 reduces tumor progression and improves survival in p53 null mice  Journal Articles
• YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins  Journal Articles
• A Multicenter Phase II Study of “Adjuvant” Irinotecan Following Resection of Colorectal Hepatic Metastases  Journal Articles
• A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer  Journal Articles
• A Role of p73 in Mitotic Exit  Journal Articles
• A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane  Journal Articles
• A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen  Journal Articles
• A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL  Journal Articles
• A role for p53 in the response of bystander cells to receipt of medium borne signals from irradiated cells  Journal Articles
• ARMMs as a versatile platform for intracellular delivery of macromolecules  Journal Articles
• ATM activation is accompanied with earlier stages of prostate tumorigenesis  Journal Articles
• ATM activity contributes to the tumor-suppressing functions of p14ARF  Journal Articles
• ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence  Journal Articles
• Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia  Journal Articles
• Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms  Journal Articles
• Accuracy of p53 Codon 72 Polymorphism Status Determined by Multiple Laboratory Methods: A Latent Class Model Analysis  Journal Articles
• Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.  Journal Articles
• Allelic Expression Imbalance ofTP53Mutated and Polymorphic Alleles in Head and Neck Tumors  Journal Articles
• Alterations in Mitochondrial and Apoptosis‐regulating Gene Expression in Photodynamic Therapy‐resistant Variants of HT29 Colon Carcinoma Cells^¶  Journal Articles
• An Observed Effect of p53 Status on the Bystander Response to Radiation-Induced Cellular Photon Emission  Journal Articles
• Apoptosis and other effects of radiation in normal human urothelial cells  Journal Articles
• Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway  Journal Articles
• Assessment of p53 overexpression by non‐immunohistochemical methods  Journal Articles
• Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer  Journal Articles
• Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.  Journal Articles
• Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study  Journal Articles
• Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation  Journal Articles
• ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters  Journal Articles
• ChIP-on-chip to Identify Mutant p53 Targets  Journal Articles
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Journal Articles
• Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain  Journal Articles
• Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation  Journal Articles
• Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53  Journal Articles
• Comparison of Immunofluorometry and Immunohistochemistry for the Detection of p53 Protein in Lung Cancer Specimens  Journal Articles
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Journal Articles
• Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy  Journal Articles
• Customized Viral Immunotherapy for HPV-Associated Cancer  Journal Articles
• DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes  Journal Articles
• DNp73α protects myogenic cells from apoptosis  Journal Articles
• Deterministic evolution and stringent selection during preneoplasia  Journal Articles
• Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients  Journal Articles
• Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells  Journal Articles
• Direct anti‐cancer effect of oncostatin M on chondrosarcoma  Journal Articles
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.  Journal Articles
• Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation  Journal Articles
• Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy  Journal Articles
• Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer?  Journal Articles
• Drugging the Master Regulator TP53 in Cancer: Mission Possible?  Journal Articles
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Journal Articles
• Early Dexamethasone Treatment Induces Placental Apoptosis in Sheep  Journal Articles
• Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination  Journal Articles
• Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: a prognostic factor in a large breast cancer cohort.  Conferences
• Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy.  Conferences
• Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens  Journal Articles
• Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients  Journal Articles
• Expression of p53 in urothelial cell cultures from tumour-bearing and tumour-free patients  Journal Articles
• Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations  Journal Articles
• From p63 to p53 across p73  Journal Articles
• Further Investigation of the Response of Human Uroepithelium to Low Doses of Cobalt-60 Gamma Radiation  Journal Articles
• Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  Journal Articles
• Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation  Journal Articles
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Journal Articles
• Gender, mutant p53 and PML: A growing “affaire” in tumor suppression and oncogenesis  Journal Articles
• Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer  Journal Articles
• HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation  Journal Articles
• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function  Journal Articles
• High Levels of Stable p53 Protein and the Expression of c-myc in Cultured Human Epithelial Tissue after Cobalt-60 Irradiation  Journal Articles
• ID4: a new player in the cancer arena  Journal Articles
• IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms  Journal Articles
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Journal Articles
• Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators  Journal Articles
• Immunofluorometric assay of p53 protein versus sequencing of p53 exons 5 to 9 for the detection of p53 abnormalities in ovarian carcinoma.  Journal Articles
• Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients  Journal Articles
• Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients  Journal Articles
• Impact of a complex nutraceutical supplement on primary tumour formation and metastasis in Trp53+/– cancer-prone mice  Journal Articles
• Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma  Journal Articles
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Journal Articles
• Increased Endocrine Cells in Treated Rectal Adenocarcinomas  Journal Articles
• Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells  Journal Articles
• Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs  Journal Articles
• Induction of Mdm2 and enhancement of cell survival by bFGF  Journal Articles
• Induction of Stable p53 Oncoprotein and of c-myc Overexpression in Cultured Normal Human Uroepithelium by Radiation and N-Nitrosodiethanolamine  Journal Articles
• Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53  Journal Articles
• Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.  Journal Articles
• Induction of multiple PCR-SSCPE mobility shifts in exons in cultures of normal human urothelium exposed to low-dose gamma radiation  Journal Articles
• Influence of Prior Exposure to Low-Dose Adapting Radiation on Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function  Journal Articles
• Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells  Journal Articles
• Inhibition of RNA polymerase II as a trigger for the p53 response  Journal Articles
• Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain  Journal Articles
• Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1  Journal Articles
• Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study  Journal Articles
• Interference with p53 protein inhibits hematopoietic and muscle differentiation.  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells  Journal Articles
• Lipidomic analysis of skeletal muscle tissues of p53 knockout mice by nUPLC-ESI-MS/MS  Journal Articles
• Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma  Journal Articles
• Loss of Wasl improves pancreatic cancer outcome  Journal Articles
• Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells  Journal Articles
• Low-dose radiation from 18F-FDG PET does not increase cancer frequency or shorten latency but reduces kidney disease in cancer-prone Trp53+/− mice  Journal Articles
• MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer  Journal Articles
• Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death  Journal Articles
• Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle  Journal Articles
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Journal Articles
• MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function  Journal Articles
• MicroRNAs as Key Effectors in the p53 Network  Journal Articles
• Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53  Journal Articles
• Monoclonal antibodies raised against Xenopus p53 interact with human p73  Journal Articles
• Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells  Journal Articles
• Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers  Journal Articles
• Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression  Journal Articles
• Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo  Journal Articles
• Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop  Journal Articles
• Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma  Journal Articles
• Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop  Journal Articles
• Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition  Journal Articles
• Mutant p53 proteins: Between loss and gain of function  Journal Articles
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Journal Articles
• Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth  Journal Articles
• Mutant p53: an oncogenic transcription factor  Journal Articles
• Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression  Journal Articles
• New therapeutic strategies to treat human cancers expressing mutant p53 proteins  Journal Articles
• Novel insights into the cytoplasmic functions of p53  Journal Articles
• Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells  Journal Articles
• PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma  Journal Articles
• Parallel comparison of pre-conditioning and post-conditioning effects in human cancers and keratinocytes upon acute gamma irradiation  Journal Articles
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis  Journal Articles
• Phase II trial of vorinostat in advanced melanoma  Journal Articles
• Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity  Journal Articles
• Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo  Journal Articles
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross‐Resistance to UVA but not UVC Light  Journal Articles
• Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities  Journal Articles
• Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73  Journal Articles
• Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression  Journal Articles
• Potential roles for p53 in nucleotide excision repair  Journal Articles
• Primary Explants of Human Uroepithelium Show an Unusual Response to Low-Dose Irradiation with Cobalt-60 Gamma Rays  Journal Articles
• Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis  Journal Articles
• Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53  Journal Articles
• Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer  Journal Articles
• Quantitative analysis of p53 protein in non-small cell lung cancer and its prognostic value  Journal Articles
• RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice  Journal Articles
• Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function: Influence of Prior Heat Stress  Journal Articles
• Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth  Journal Articles
• Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis  Journal Articles
• Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2  Journal Articles
• Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown  Journal Articles
• Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter¶  Journal Articles
• S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation  Journal Articles
• Single CT Scan Prolongs Survival by Extending Cancer Latency inTrp53Heterozygous Mice  Journal Articles
• Stability strengths oncogenic activity  Journal Articles
• TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma  Journal Articles
• Targeting mutant p53 in cancer: the latest insights  Journal Articles
• Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer.  Journal Articles
• Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition  Journal Articles
• Teratogenic Effects of Mild Heat Stress during Mouse Embryogenesis: Effect ofTrp53  Journal Articles
• Tetraploidy triggers mithocondria  Journal Articles
• The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein  Journal Articles
• The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1 -Related Breast Cancer  Journal Articles
• The Role of the p53 Tumor Suppressor in the Response of Human Cells to Photofrin-mediated Photodynamic Therapy  Journal Articles
• The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs  Journal Articles
• The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis  Journal Articles
• The mutant p53‐ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1  Journal Articles
• The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex  Journal Articles
• The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells  Journal Articles
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults  Journal Articles
• The role of the human papilloma virus in esophageal cancer  Journal Articles
• Time-resolved immunofluorometric assay of p53 protein  Journal Articles
• Time-resolved immunofluorometric assay of p53 protein.  Journal Articles
• Towards a biological staging model for operable non-small cell lung cancer  Journal Articles
• Transcriptional Regulation by Mutant p53 and Oncogenesis  Journal Articles
• Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis  Journal Articles
• Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy  Journal Articles
• Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables  Journal Articles
• Two distinct TP53 mutations in HNSCC primary tumor: Only one circulates in the blood  Journal Articles
• USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation  Journal Articles
• UV-inducible base excision repair of oxidative damaged DNA in human cells  Journal Articles
• Use of latent class models to accommodate inter-laboratory variation in assessing genetic polymorphisms associated with disease risk  Journal Articles
• Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification  Journal Articles
• Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine.  Journal Articles
• WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma  Journal Articles
• Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease  Journal Articles
• Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes  Journal Articles
• Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells  Journal Articles
• Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.  Journal Articles
• YAP1 Meets Tumor Suppression  Journal Articles
• p21WAF1 protein expression determined by quantitative immunoassay in relation to non-small-cell lung cancer aggressiveness  Journal Articles
• p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts  Journal Articles
• p53 mutations and protein expression in primary cultures of normal oral mucosa in smokers and non-smokers  Journal Articles
• p53 protein expression and increased SSCP mobility shifts in the p53 gene in normal urothelium cultured from smokers  Journal Articles
• p53 protein is absent from the serum of patients with lung cancer  Journal Articles
• p53: The pivot between cell cycle arrest and senescence  Journal Articles
• p73 and p63: Why Do We Still Need Them?  Journal Articles
• p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53  Journal Articles
• p73-induced apoptosis: A question of compartments and cooperation  Journal Articles
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Journal Articles