Tumor Suppressor Protein p53 Concept

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• Id2gene is a transcriptional target of the protein complex mutant p53/E2F1  Academic Article
• p53 Arg72Pro and MDM2 T309G Polymorphisms, Histology, and Esophageal Cancer Prognosis  Academic Article
• AMPK β1 reduces tumor progression and improves survival in p53 null mice  Academic Article
• YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins  Academic Article
• A Multicenter Phase II Study of “Adjuvant” Irinotecan Following Resection of Colorectal Hepatic Metastases  Academic Article
• A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer  Academic Article
• A Role of p73 in Mitotic Exit  Academic Article
• A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane  Academic Article
• A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen  Academic Article
• A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL  Academic Article
• A role for p53 in the response of bystander cells to receipt of medium borne signals from irradiated cells  Academic Article
• ARMMs as a versatile platform for intracellular delivery of macromolecules  Academic Article
• ATM activation is accompanied with earlier stages of prostate tumorigenesis  Academic Article
• ATM activity contributes to the tumor-suppressing functions of p14ARF  Academic Article
• ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence  Academic Article
• Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia  Academic Article
• Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.  Academic Article
• Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms  Academic Article
• Accuracy of p53 Codon 72 Polymorphism Status Determined by Multiple Laboratory Methods: A Latent Class Model Analysis  Academic Article
• Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.  Academic Article
• Allelic Expression Imbalance ofTP53Mutated and Polymorphic Alleles in Head and Neck Tumors  Academic Article
• Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶  Academic Article
• Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶  Academic Article
• An Observed Effect of p53 Status on the Bystander Response to Radiation-Induced Cellular Photon Emission  Academic Article
• Apoptosis and other effects of radiation in normal human urothelial cells  Academic Article
• Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway  Academic Article
• Assessment of p53 overexpression by non-immunohistochemical methods  Academic Article
• Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer  Academic Article
• Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.  Academic Article
• Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study  Academic Article
• Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation  Academic Article
• ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters  Academic Article
• ChIP-on-chip to Identify Mutant p53 Targets  Academic Article
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Academic Article
• Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain  Academic Article
• Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation  Academic Article
• Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53  Academic Article
• Comparison of Immunofluorometry and Immunohistochemistry for the Detection of p53 Protein in Lung Cancer Specimens  Academic Article
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Academic Article
• Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy  Academic Article
• Customized Viral Immunotherapy for HPV-Associated Cancer  Academic Article
• DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes  Academic Article
• DNp73α protects myogenic cells from apoptosis  Academic Article
• Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells  Academic Article
• Direct anti-cancer effect of oncostatin M on chondrosarcoma  Academic Article
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.  Academic Article
• Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation  Academic Article
• Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy  Academic Article
• Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer?  Academic Article
• Drugging the Master Regulator TP53 in Cancer: Mission Possible?  Academic Article
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Academic Article
• Early Dexamethasone Treatment Induces Placental Apoptosis in Sheep  Academic Article
• Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination  Academic Article
• Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: a prognostic factor in a large breast cancer cohort.  Conference Paper
• Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy.  Conference Paper
• Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens  Academic Article
• Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients  Academic Article
• Expression of p53 in urothelial cell cultures from tumour-bearing and tumour-free patients  Academic Article
• Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations  Academic Article
• From p63 to p53 across p73  Academic Article
• Further Investigation of the Response of Human Uroepithelium to Low Doses of Cobalt-60 Gamma Radiation  Academic Article
• Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  Academic Article
• Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation  Academic Article
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Academic Article
• Gender, mutant p53 and PML: A growing “affaire” in tumor suppression and oncogenesis  Academic Article
• Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer  Academic Article
• HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation  Academic Article
• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function  Academic Article
• High Levels of Stable p53 Protein and the Expression of c-myc in Cultured Human Epithelial Tissue after Cobalt-60 Irradiation  Academic Article
• ID4: a new player in the cancer arena.  Academic Article
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Academic Article
• Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators  Academic Article
• Immunofluorometric assay of p53 protein versus sequencing of p53 exons 5 to 9 for the detection of p53 abnormalities in ovarian carcinoma.  Academic Article
• Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients  Academic Article
• Impact of a complex nutraceutical supplement on primary tumour formation and metastasis in Trp53+/– cancer-prone mice  Academic Article
• Impact of germlineBRCA1mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma  Academic Article
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Academic Article
• Increased Endocrine Cells in Treated Rectal Adenocarcinomas  Academic Article
• Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells  Academic Article
• Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs  Academic Article
• Induction of Mdm2 and enhancement of cell survival by bFGF  Academic Article
• Induction of Stable p53 Oncoprotein and of c-myc Overexpression in Cultured Normal Human Uroepithelium by Radiation and N-Nitrosodiethanolamine  Academic Article
• Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53  Academic Article
• Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.  Academic Article
• Induction of multiple PCR-SSCPE mobility shifts in exons in cultures of normal human urothelium exposed to low-dose gamma radiation  Academic Article
• Influence of Prior Exposure to Low-Dose Adapting Radiation on Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function  Academic Article
• Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells  Academic Article
• Inhibition of RNA polymerase II as a trigger for the p53 response  Academic Article
• Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain  Academic Article
• Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1  Academic Article
• Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study  Academic Article
• Interference with p53 protein inhibits hematopoietic and muscle differentiation.  Academic Article
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Academic Article
• Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells  Academic Article
• Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial  Academic Article
• Lipidomic analysis of skeletal muscle tissues of p53 knockout mice by nUPLC-ESI-MS/MS  Academic Article
• Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma  Academic Article
• Loss of Wasl improves pancreatic cancer outcome  Academic Article
• Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells.  Academic Article
• Low-dose radiation from 18F-FDG PET does not increase cancer frequency or shorten latency but reduces kidney disease in cancer-prone Trp53+/− mice  Academic Article
• MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer  Academic Article
• Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death  Academic Article
• Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle  Academic Article
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Academic Article
• MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function  Academic Article
• MicroRNAs as Key Effectors in the p53 Network  Academic Article
• Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53  Academic Article
• Monoclonal antibodies raised against Xenopus p53 interact with human p73  Academic Article
• Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome  Academic Article
• Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells  Academic Article
• Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers  Academic Article
• Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression  Academic Article
• Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop  Academic Article
• Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma  Academic Article
• Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop  Academic Article
• Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition  Academic Article
• Mutant p53 proteins: Between loss and gain of function  Academic Article
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Academic Article
• Mutant p53: an oncogenic transcription factor  Academic Article
• Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression  Academic Article
• New therapeutic strategies to treat human cancers expressing mutant p53 proteins  Academic Article
• Novel insights into the cytoplasmic functions of p53  Academic Article
• Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells  Academic Article
• PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma  Academic Article
• Parallel comparison of pre-conditioning and post-conditioning effects in human cancers and keratinocytes upon acute gamma irradiation  Academic Article
• Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis  Academic Article
• Phase II trial of vorinostat in advanced melanoma  Academic Article
• Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity  Academic Article
• Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo  Academic Article
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light  Academic Article
• Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities  Academic Article
• Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73  Academic Article
• Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression  Academic Article
• Potential roles for p53 in nucleotide excision repair  Academic Article
• Primary Explants of Human Uroepithelium Show an Unusual Response to Low-Dose Irradiation with Cobalt-60 Gamma Rays  Academic Article
• Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis  Academic Article
• Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53  Academic Article
• Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer  Academic Article
• Quantitative analysis of p53 protein in non-small cell lung cancer and its prognostic value  Academic Article
• RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice  Academic Article
• Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function: Influence of Prior Heat Stress  Academic Article
• Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth  Academic Article
• Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis  Academic Article
• Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2  Academic Article
• Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown  Academic Article
• Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter¶  Academic Article
• S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation  Academic Article
• Single CT Scan Prolongs Survival by Extending Cancer Latency inTrp53Heterozygous Mice  Academic Article
• Stability strengths oncogenic activity  Academic Article
• Targeting mutant p53 in cancer: the latest insights  Academic Article
• Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition  Academic Article
• Teratogenic Effects of Mild Heat Stress during Mouse Embryogenesis: Effect ofTrp53  Academic Article
• Tetraploidy triggers mithocondria  Academic Article
• The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein  Academic Article
• The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1 -Related Breast Cancer  Academic Article
• The Role of the p53 Tumor Suppressor in the Response of Human Cells to Photofrin-mediated Photodynamic Therapy  Academic Article
• The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs  Academic Article
• The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis  Academic Article
• The mutant p53‐ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1  Academic Article
• The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex  Academic Article
• The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells  Academic Article
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults  Academic Article
• The role of the human papilloma virus in esophageal cancer  Academic Article
• Time-resolved immunofluorometric assay of p53 protein  Academic Article
• Time-resolved immunofluorometric assay of p53 protein.  Academic Article
• Towards a biological staging model for operable non-small cell lung cancer  Academic Article
• Transcriptional Regulation by Mutant p53 and Oncogenesis  Academic Article
• Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis  Academic Article
• Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy  Academic Article
• Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables  Academic Article
• Two distinct TP53 mutations in HNSCC primary tumor: Only one circulates in the blood  Academic Article
• USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation  Academic Article
• UV-inducible base excision repair of oxidative damaged DNA in human cells  Academic Article
• Use of latent class models to accommodate inter-laboratory variation in assessing genetic polymorphisms associated with disease risk  Academic Article
• Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification  Academic Article
• Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine.  Academic Article
• WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma  Academic Article
• Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease  Academic Article
• Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes  Academic Article
• Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells  Academic Article
• Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.  Academic Article
• YAP1 Meets Tumor Suppression  Academic Article
• p21WAF1 protein expression determined by quantitative immunoassay in relation to non-small-cell lung cancer aggressiveness  Academic Article
• p53 - The Link between Inflammation and Cancer?  Academic Article
• p53 - The link between inflammation and cancer? A review of: Hudson JD, Shoaibi MA, Maestro R, et al. - 1999 - A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190 : 1375-1382.  Academic Article
• p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts  Academic Article
• p53 mutations and protein expression in primary cultures of normal oral mucosa in smokers and non-smokers  Academic Article
• p53 protein expression and increased SSCP mobility shifts in the p53 gene in normal urothelium cultured from smokers  Academic Article
• p53 protein is absent from the serum of patients with lung cancer  Academic Article
• p53: The pivot between cell cycle arrest and senescence  Academic Article
• p73 and p63: Why Do We Still Need Them?  Academic Article
• p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53  Academic Article
• p73-induced apoptosis: A question of compartments and cooperation  Academic Article
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Academic Article