Tumor Suppressor Protein p53
Concept
Vocabulary Service
Overview
subject area of
-
Id2gene is a transcriptional target of the protein complex mutant p53/E2F1 Academic Article
-
p53 Arg72Pro and MDM2 T309G Polymorphisms, Histology, and Esophageal Cancer Prognosis Academic Article
-
AMPK β1 reduces tumor progression and improves survival in p53 null mice Academic Article
-
YAP
enhances the pro‐proliferative transcriptional activity of mutant p53 proteins Academic Article
-
A Multicenter Phase II Study of “Adjuvant” Irinotecan Following Resection of Colorectal Hepatic Metastases Academic Article
-
A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer Academic Article
-
A Role of p73 in Mitotic Exit Academic Article
-
A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane Academic Article
-
A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen Academic Article
-
A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL Academic Article
-
A role for p53 in the response of bystander cells to receipt of medium borne signals from irradiated cells Academic Article
-
ARMMs as a versatile platform for intracellular delivery of macromolecules Academic Article
-
ATM activation is accompanied with earlier stages of prostate tumorigenesis Academic Article
-
ATM activity contributes to the tumor-suppressing functions of p14ARF Academic Article
-
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence Academic Article
-
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia Academic Article
-
Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. Academic Article
-
Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms Academic Article
-
Accuracy of p53 Codon 72 Polymorphism Status Determined by Multiple Laboratory Methods: A Latent Class Model Analysis Academic Article
-
Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. Academic Article
-
Allelic Expression Imbalance ofTP53Mutated and Polymorphic Alleles in Head and Neck Tumors Academic Article
-
Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶ Academic Article
-
Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶ Academic Article
-
An Observed Effect of p53 Status on the Bystander Response to Radiation-Induced Cellular Photon Emission Academic Article
-
Apoptosis and other effects of radiation in normal human urothelial cells Academic Article
-
Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway Academic Article
-
Assessment of p53 overexpression by non-immunohistochemical methods Academic Article
-
Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer Academic Article
-
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. Academic Article
-
Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study Academic Article
-
Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation Academic Article
-
ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters Academic Article
-
ChIP-on-chip to Identify Mutant p53 Targets Academic Article
-
Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73 Academic Article
-
Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain Academic Article
-
Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation Academic Article
-
Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53 Academic Article
-
Comparison of Immunofluorometry and Immunohistochemistry for the Detection of p53 Protein in Lung Cancer Specimens Academic Article
-
Compromised genomic integrity impedes muscle growth after Atrx inactivation Academic Article
-
Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy Academic Article
-
Customized Viral Immunotherapy for HPV-Associated Cancer Academic Article
-
DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes Academic Article
-
DNp73α protects myogenic cells from apoptosis Academic Article
-
Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells Academic Article
-
Direct anti-cancer effect of oncostatin M on chondrosarcoma Academic Article
-
Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. Academic Article
-
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation Academic Article
-
Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy Academic Article
-
Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer? Academic Article
-
Drugging the Master Regulator TP53 in Cancer: Mission Possible? Academic Article
-
ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53 Academic Article
-
Early Dexamethasone Treatment Induces Placental Apoptosis in Sheep Academic Article
-
Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination Academic Article
-
Enzyme-linked immunoabsorbent assay-detected p53 protein accumulation: a prognostic factor in a large breast cancer cohort. Conference Paper
-
Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy. Conference Paper
-
Expression of Lethal Mutations Is Suppressed in Neoplastically Transformed Cells and after Treatment of Normal Cells with Carcinogens Academic Article
-
Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients Academic Article
-
Expression of p53 in urothelial cell cultures from tumour-bearing and tumour-free patients Academic Article
-
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations Academic Article
-
From p63 to p53 across p73 Academic Article
-
Further Investigation of the Response of Human Uroepithelium to Low Doses of Cobalt-60 Gamma Radiation Academic Article
-
Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression Academic Article
-
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Academic Article
-
Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells Academic Article
-
Gender, mutant p53 and PML: A growing “affaire” in tumor suppression and oncogenesis Academic Article
-
Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer Academic Article
-
HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation Academic Article
-
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Academic Article
-
High Levels of Stable p53 Protein and the Expression of c-myc in Cultured Human Epithelial Tissue after Cobalt-60 Irradiation Academic Article
-
ID4: a new player in the cancer arena. Academic Article
-
Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression Academic Article
-
Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators Academic Article
-
Immunofluorometric assay of p53 protein versus sequencing of p53 exons 5 to 9 for the detection of p53 abnormalities in ovarian carcinoma. Academic Article
-
Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients Academic Article
-
Impact of a complex nutraceutical supplement on primary tumour formation and metastasis in Trp53+/– cancer-prone mice Academic Article
-
Impact of germlineBRCA1mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma Academic Article
-
Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells Academic Article
-
Increased Endocrine Cells in Treated Rectal Adenocarcinomas Academic Article
-
Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells Academic Article
-
Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs Academic Article
-
Induction of Mdm2 and enhancement of cell survival by bFGF Academic Article
-
Induction of Stable p53 Oncoprotein and of c-myc Overexpression in Cultured Normal Human Uroepithelium by Radiation and N-Nitrosodiethanolamine Academic Article
-
Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53 Academic Article
-
Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53. Academic Article
-
Induction of multiple PCR-SSCPE mobility shifts in exons in cultures of normal human urothelium exposed to low-dose gamma radiation Academic Article
-
Influence of Prior Exposure to Low-Dose Adapting Radiation on Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function Academic Article
-
Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells Academic Article
-
Inhibition of RNA polymerase II as a trigger for the p53 response Academic Article
-
Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain Academic Article
-
Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1 Academic Article
-
Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study Academic Article
-
Interference with p53 protein inhibits hematopoietic and muscle differentiation. Academic Article
-
Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells Academic Article
-
Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells Academic Article
-
Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial Academic Article
-
Lipidomic analysis of skeletal muscle tissues of p53 knockout mice by nUPLC-ESI-MS/MS Academic Article
-
Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma Academic Article
-
Loss of Wasl improves pancreatic cancer outcome Academic Article
-
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells. Academic Article
-
Low-dose radiation from 18F-FDG PET does not increase cancer frequency or shorten latency but reduces kidney disease in cancer-prone Trp53+/− mice Academic Article
-
MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer Academic Article
-
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death Academic Article
-
Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle Academic Article
-
Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation Academic Article
-
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function Academic Article
-
MicroRNAs as Key Effectors in the p53 Network Academic Article
-
Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 Academic Article
-
Monoclonal antibodies raised against Xenopus p53 interact with human p73 Academic Article
-
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome Academic Article
-
Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells Academic Article
-
Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers Academic Article
-
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression Academic Article
-
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop Academic Article
-
Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma Academic Article
-
Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop Academic Article
-
Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition Academic Article
-
Mutant p53 proteins: Between loss and gain of function Academic Article
-
Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine Academic Article
-
Mutant p53: an oncogenic transcription factor Academic Article
-
Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression Academic Article
-
New therapeutic strategies to treat human cancers expressing mutant p53 proteins Academic Article
-
Novel insights into the cytoplasmic functions of p53 Academic Article
-
Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells Academic Article
-
PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma Academic Article
-
Parallel comparison of pre-conditioning and post-conditioning effects in human cancers and keratinocytes upon acute gamma irradiation Academic Article
-
Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis Academic Article
-
Phase II trial of vorinostat in advanced melanoma Academic Article
-
Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity Academic Article
-
Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo Academic Article
-
Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light Academic Article
-
Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities Academic Article
-
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73 Academic Article
-
Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression Academic Article
-
Potential roles for p53 in nucleotide excision repair Academic Article
-
Primary Explants of Human Uroepithelium Show an Unusual Response to Low-Dose Irradiation with Cobalt-60 Gamma Rays Academic Article
-
Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis Academic Article
-
Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53 Academic Article
-
Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer Academic Article
-
Quantitative analysis of p53 protein in non-small cell lung cancer and its prognostic value Academic Article
-
RETRACTED ARTICLE:Exercise-induced mitochondrial p53
repairs mtDNA mutations in mutator mice Academic Article
-
Radiation-Induced Teratogenic Effects in Fetal Mice with VaryingTrp53Function: Influence of Prior Heat Stress Academic Article
-
Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth Academic Article
-
Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis Academic Article
-
Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2 Academic Article
-
Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown Academic Article
-
Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter¶ Academic Article
-
S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation Academic Article
-
Single CT Scan Prolongs Survival by Extending Cancer Latency inTrp53Heterozygous Mice Academic Article
-
Stability strengths oncogenic activity Academic Article
-
Targeting mutant p53 in cancer: the latest insights Academic Article
-
Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition Academic Article
-
Teratogenic Effects of Mild Heat Stress during Mouse Embryogenesis: Effect ofTrp53 Academic Article
-
Tetraploidy triggers mithocondria Academic Article
-
The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein Academic Article
-
The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of
BRCA1
-Related Breast Cancer Academic Article
-
The Role of the p53 Tumor Suppressor in the Response of Human Cells to Photofrin-mediated Photodynamic Therapy Academic Article
-
The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs Academic Article
-
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis Academic Article
-
The mutant p53‐ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1 Academic Article
-
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex Academic Article
-
The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells Academic Article
-
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults Academic Article
-
The role of the human papilloma virus in esophageal cancer Academic Article
-
Time-resolved immunofluorometric assay of p53 protein Academic Article
-
Time-resolved immunofluorometric assay of p53 protein. Academic Article
-
Towards a biological staging model for operable non-small cell lung cancer Academic Article
-
Transcriptional Regulation by Mutant p53 and Oncogenesis Academic Article
-
Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis Academic Article
-
Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy Academic Article
-
Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables Academic Article
-
Two distinct TP53 mutations in HNSCC primary tumor: Only one circulates in the blood Academic Article
-
USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation Academic Article
-
UV-inducible base excision repair of oxidative damaged DNA in human cells Academic Article
-
Use of latent class models to accommodate inter-laboratory variation in assessing genetic polymorphisms associated with disease risk Academic Article
-
Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification Academic Article
-
Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine. Academic Article
-
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma Academic Article
-
Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease Academic Article
-
Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes Academic Article
-
Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells Academic Article
-
Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells. Academic Article
-
YAP1 Meets Tumor Suppression Academic Article
-
p21WAF1 protein expression determined by quantitative immunoassay in relation to non-small-cell lung cancer aggressiveness Academic Article
-
p53 - The Link between Inflammation and Cancer? Academic Article
-
p53 - The link between inflammation and cancer? A review of: Hudson JD, Shoaibi MA, Maestro R, et al. - 1999 - A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190 : 1375-1382. Academic Article
-
p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts Academic Article
-
p53 mutations and protein expression in primary cultures of normal oral mucosa in smokers and non-smokers Academic Article
-
p53 protein expression and increased SSCP mobility shifts in the p53 gene in normal urothelium cultured from smokers Academic Article
-
p53 protein is absent from the serum of patients with lung cancer Academic Article
-
p53: The pivot between cell cycle arrest and senescence Academic Article
-
p73 and p63: Why Do We Still Need Them? Academic Article
-
p73-Mediated Chemosensitivity: A Preferential Target of Oncogenic Mutant p53 Academic Article
-
p73-induced apoptosis: A question of compartments and cooperation Academic Article
-
β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer Academic Article