Journal article
The role of the human papilloma virus in esophageal cancer
Abstract
Esophageal squamous cell carcinoma (ESCC) demonstrates wide regional variation in incidence and causal associations. Human papillomavirus (HPV) has been implicated in ESCC, particularly the sub-types 16 and 18. Transforming proteins E6 and E7 from these high risk sub-types, interact with p53 protein and Rb protein respectively, leading to loss of function of these tumor suppressor gene products. These interactions further lead to inactivation …
Authors
Sur M; Cooper K
Journal
Pathology, Vol. 30, No. 4, pp. 348–354
Publisher
Elsevier
Publication Date
1998
DOI
10.1080/00313029800169616
ISSN
0031-3025