Journal article
DNp73α protects myogenic cells from apoptosis
Abstract
The P73 gene is transcribed from two promoters, P1 and P2, that direct the expression of multiple transactivation competent (TA) and dominant negative (DN) isoforms. TAp73 transcription factors mediate cell cycle arrest and/or apoptosis in response to DNA damage and are involved in developmental processes. P73 mRNA levels increase and the P1p73 promoter is upregulated during myogenic differentiation of C2C12 skeletal muscle satellite cells. The …
Authors
Belloni L; Moretti F; Merlo P; Damalas A; Costanzo A; Blandino G; Levrero M
Journal
Oncogene, Vol. 25, No. 25, pp. 3606–3612
Publisher
Springer Nature
Publication Date
June 15, 2006
DOI
10.1038/sj.onc.1209321
ISSN
0950-9232