Journal article
Direct anti‐cancer effect of oncostatin M on chondrosarcoma
Abstract
The cytokine Oncostatin M (OSM) is cytostatic, pro-apoptotic and induces differentiation of osteosarcoma cells into osteocytes, suggesting new adjuvant treatment for these bone-forming sarcomas. However, OSM systemic over-expression could lead to adverse side effects such as generalized inflammation, neoangiogenesis and osteolysis. We determine here the effect of OSM on chondrosarcoma, another primary bone sarcoma characterized by the …
Authors
David E; Guihard P; Brounais B; Riet A; Charrier C; Battaglia S; Gouin F; Ponsolle S; Le Bot R; Richards CD
Journal
International Journal of Cancer, Vol. 128, No. 8, pp. 1822–1835
Publisher
Wiley
Publication Date
April 15, 2011
DOI
10.1002/ijc.25776
ISSN
0020-7136
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsAntineoplastic AgentsApoptosisBlotting, WesternCell CycleCell DifferentiationCell ProliferationChondrosarcomaCore Binding Factor Alpha 1 SubunitJanus Kinase 3MaleMatrix Metalloproteinase 13MiceOncostatin MOsteoclastsRANK LigandRNA, MessengerRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionSOX9 Transcription FactorSTAT1 Transcription FactorSurvival RateTumor Cells, CulturedTumor Suppressor Protein p53