Journal article
Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells
Abstract
We have reported previously the isolation of three photodynamic therapy (PDT)-resistant human colon carcinoma HT29 cell lines that show increased expression of the Hsp27 and BNip3 protein and a decreased expression of the mutant p53 protein compared to parental HT29 cells. Since mutant p53 and increased expression of Hsp27 have been associated with resistance to various chemotherapeutic agents, whereas BNip3 is a potent inducer of apoptosis, we …
Authors
Zacal N; Espiritu M; Singh G; Rainbow AJ
Journal
Biochemical and Biophysical Research Communications, Vol. 331, No. 2, pp. 648–657
Publisher
Elsevier
Publication Date
6 2005
DOI
10.1016/j.bbrc.2005.03.213
ISSN
0006-291X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsApoptosisCell SurvivalCisplatinDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGenes, p53HSP27 Heat-Shock ProteinsHT29 CellsHeat-Shock ProteinsHumansMembrane ProteinsMolecular ChaperonesMutationNeoplasm ProteinsPhotochemotherapyProto-Oncogene ProteinsTumor Suppressor Protein p53