Journal article
Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis
Abstract
The mechanisms that regulate the enhanced skeletal muscle oxidative capacity observed when training with reduced carbohydrate (CHO) availability are currently unknown. The aim of the present study was to test the hypothesis that reduced CHO availability enhances p53 signaling and expression of genes associated with regulation of mitochondrial biogenesis and substrate utilization in human skeletal muscle. In a repeated-measures design, muscle …
Authors
Bartlett JD; Louhelainen J; Iqbal Z; Cochran AJ; Gibala MJ; Gregson W; Close GL; Drust B; Morton JP
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 304, No. 6, pp. r450–r458
Publisher
American Physiological Society
Publication Date
March 15, 2013
DOI
10.1152/ajpregu.00498.2012
ISSN
0363-6119