Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer Journal Articles uri icon

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abstract

  • Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2-3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.

authors

  • Goffin, John
  • Straume, O
  • Chappuis, PO
  • Brunet, J-S
  • Bégin, LR
  • Hamel, N
  • Wong, N
  • Akslen, LA
  • Foulkes, WD

publication date

  • September 2003

has subject area