Journal article
p53 Arg72Pro and MDM2 T309G Polymorphisms, Histology, and Esophageal Cancer Prognosis
Abstract
PURPOSE: This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships.
EXPERIMENTAL DESIGN: A cohort of 371 patients with esophageal carcinoma enrolled in Boston, USA from 1999 to 2004 were genotyped for the p53 and MDM2 …
Authors
Cescon DW; Bradbury PA; Asomaning K; Hopkins J; Zhai R; Zhou W; Wang Z; Kulke M; Su L; Ma C
Journal
Clinical Cancer Research, Vol. 15, No. 9, pp. 3103–3109
Publisher
American Association for Cancer Research (AACR)
Publication Date
May 1, 2009
DOI
10.1158/1078-0432.ccr-08-3120
ISSN
1078-0432
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenocarcinomaAdultAgedAged, 80 and overArginineBostonCarcinoma, Squamous CellCell DifferentiationCohort StudiesEsophageal NeoplasmsFemaleGenotypeHumansMaleMiddle AgedNeoplasm Recurrence, LocalPolymorphism, Single NucleotidePrognosisProlineProspective StudiesProto-Oncogene Proteins c-mdm2Survival RateTumor Suppressor Protein p53Young Adult