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EFFECTIVENESS OF IMPLEMENTATION INTERVENTIONS IN IMPROVING PHYSICIAN ADHERENCE TO GUIDELINE RECOMMENDATIONS IN HEART FAILURE: A SYSTEMATIC REVIEW 2017
Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study).. 14:e084825. 2024
Mapping context of sedentary behaviour in older adults who are prefrail and frail: an analysis of secondary outcomes from a longitudinal study (MAPS-B).. 14:e084610. 2024
Physical activity promotion intervention improved physical activity knowledge, confidence and behaviour among diverse immigrant women: pre-post multiple methods feasibility study.. 14:e086653. 2024
Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience): study protocol of a mental health, HIV self-testing and livelihoods randomised controlled trial for advancing HIV prevention outcomes among urban refugee youth in Kampala, Uganda.. 14:e087470. 2024
Multicentre randomised controlled trial comparing Bankart repair with remplissage and Latarjet procedure in shoulder instability with subcritical bone loss (STABLE): study protocol.. 14:e089831. 2024
Methodological standards in the design and reporting of pilot and feasibility studies in emergency medicine literature: a systematic review.. 14:e082648. 2024
Nepal Family Cohort study: a study protocol.. 14:e088896. 2024
Perspectives on the sustained engagement with digital health tools: protocol for a qualitative interview study among people living with Inflammatory Bowel Disease or irritable bowel syndrome.. 14:e089220. 2024
Experiences of physiotherapists working with adults living with Long COVID in Canada: a qualitative study.. 14:e086357. 2024
Traditional, complementary and integrative medicine therapies for the treatment of mild/moderate acute COVID-19: protocol for a systematic review and network meta-analysis.. 14:e088959. 2024
Quality and completeness of, and spin in reporting of, pilot and feasibility studies in hip and knee arthroplasty: a protocol for a methodological survey.. 14:e085441. 2024
Implementation of an electronic prospective surveillance model for cancer rehabilitation: a mixed methods study protocol.. 14:e090449. 2024
Road to Recovery: protocol for a mixed-methods prospective cohort study evaluating the impact of a new model of substance use care in a Canadian setting.. 14:e090608. 2024
Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022.. 14:e087724. 2024
Fatherhood and men's participation in antenatal care in rural sub-Saharan Africa: a scoping review protocol.. 14:e085901. 2024
Supported decision-making with persons with dementia: a scoping review protocol in partnership with lived experts. 14:e085954-e085954. 2024
Disparity between statistical and clinical significance in published randomised controlled trials indexed in PubMed: a protocol for a cross-sectional methodological survey. 14:e084375-e084375. 2024
Selective early medical treatment of the patent ductus arteriosus in extremely low gestational age infants: a pilot randomised controlled trial protocol (SMART-PDA). 14:e087998-e087998. 2024
Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial. 14:e086777-e086777. 2024
Chronic obstructive pulmonary disease exacerbation purulence status and its association with pulmonary embolism: protocol for a systematic review with meta-analysis. 14:e085328-e085328. 2024
PRECISE trial (Pain RElief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin–melatonin combination for fibromyalgia. 14:e087180-e087180. 2024
Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative. 14:e083752-e083752. 2024
Coordination of oral anticoagulant care at hospital discharge (COACHeD): pilot randomised controlled trial. 14:e079353-e079353. 2024
Describing primary care patterns before and during the COVID-19 pandemic across Canada: a quasi-experimental pre–post design cohort study using national practice-based research network data. 14:e084608-e084608. 2024
Impact of social determinants of health on progression from potentially life-threatening complications to near miss events and death during pregnancy and post partum in a middle-income setting: an observational study. 14:e081996-e081996. 2024
Patient, caregiver and other knowledge user engagement in consensus-building healthcare initiatives: a scoping review protocol. 14:e080822-e080822. 2024
Protocol for the development of the Chatbot Assessment Reporting Tool (CHART) for clinical advice. 14:e081155-e081155. 2024
Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review. 14:e081118-e081118. 2024
‘It’s just my knee’: a qualitative study investigating the process of reframing and young athletes’ perceived quality of life between anterior cruciate ligament injury and surgery. 14:e076799-e076799. 2024
Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review. 14:e079750-e079750. 2024
Global trends in chronic kidney disease-related mortality: a systematic review protocol. 14:e078485-e078485. 2024
REporting quality of PilOt randomised controlled trials in surgery (REPORTS): a methodological survey protocol. 14:e085293-e085293. 2024
The Pediatric Autism Research Cohort (PARC) Study: protocol for a patient-oriented prospective study examining trajectories of functioning in children with autism. 14:e083045-e083045. 2024
Co-creating a new Charter for equitable and inclusive co-creation: insights from an international forum of academic and lived experience experts. 14:e078950-e078950. 2024
Developing a reporting item checklist for studies of HIV drug resistance prevalence or incidence: a mixed methods study. 14:e080014-e080014. 2024
Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews. 14:e078217-e078217. 2024
Investigation of divergent thinking among surgeons and surgeon trainees in Canada (IDEAS): a mixed-methods study. 14:e081367-e081367. 2024
Prepregnancy body mass index and other risk factors for early-onset and late-onset haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a population-based retrospective cohort study in British Columbia, Canada. 14:e079131-e079131. 2024
Effects of ambient air pollution on obesity and ectopic fat deposition: a protocol for a systematic review and meta-analysis. 14:e080026-e080026. 2024
Sepsis policy, guidelines and standards in Canada: a jurisdictional scoping review protocol. 14:e077909-e077909. 2024
Understanding the use and outcomes of high-flow nasal cannula among infants admitted to Canadian hospitals with bronchiolitis (CanFLO): a protocol for a multicentre, retrospective cohort study. 14:e080197-e080197. 2024
Cannabis for medical use versus opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised clinical trials. 14:e068182-e068182. 2024
International consensus statement on the design, delivery and evaluation of sport-based interventions aimed at promoting social, psychological and physical well-being in prison. 14:e075792-e075792. 2024
Development of indicators for avoidable emergency medical service calls by mapping paramedic clinical impression codes to ambulatory care sensitive conditions and mental health conditions in the UK and Canada. 13:e073520-e073520. 2023
Understanding and addressing changing administrative workload in primary care in Canada: protocol for a mixed-method study. 13:e076917-e076917. 2023
What is the optimal assessment of speech? A multicentre, international evaluation of speech assessment in 2500 patients with a cleft. 13:e071571-e071571. 2023
Burden, determinants, consequences and care of multimorbidity in rural and urbanising Telangana, India: protocol for a mixed-methods study within the APCAPS cohort. 13:e073897-e073897. 2023
Cost-effectiveness analysis of the Geriatric Fracture Center (GFC) concept: a prospective multicentre cohort study. 13:e072744-e072744. 2023
Delphi consensus study to develop guidelines for the management of adults with borderline personality disorder in the emergency department: a protocol. 13:e075119-e075119. 2023
Exploring the outcomes of research engagement using the observation method in an online setting. 13:e073953-e073953. 2023
How do network meta-analyses address intransitivity when assessing certainty of evidence: a systematic survey. 13:e075212-e075212. 2023
Infographic summaries for clinical practice guidelines: results from user testing of the BMJ Rapid Recommendations in primary care. 13:e071847-e071847. 2023
Intranasal antihistamines and corticosteroids in the treatment of allergic rhinitis: a systematic review and meta-analysis protocol. 13:e076614-e076614. 2023
Perceived value and benefits of the Community Paramedicine at Clinic (CP@clinic) programme: a descriptive qualitative study. 13:e076066-e076066. 2023
Protocol for a longitudinal cohort study of Lyme disease with physical, mental and immunological assessment. 13:e076833-e076833. 2023
Protocol for validating an algorithm to identify neurocognitive disorders in Canadian Longitudinal Study on Aging participants: an observational study. 13:e073027-e073027. 2023
REVISE:Re-Evaluating theInhibition ofStressErosions in the ICU: a randomised trial protocol. 13:e075588-e075588. 2023
What are effective vaccine distribution approaches for equity-deserving and high-risk populations during COVID-19? Exploring best practices and recommendations in Canada: protocol for a mixed-methods multiple case codesign study. 13:e072238-e072238. 2023
Evaluating interactive weekly mobile phone text messaging plus motivational interviewing for breastfeeding promotion among women living with HIV, giving normal birth at a primary healthcare facility in South Africa: a feasibility randomised controlled trial. 13:e073385-e073385. 2023
Evaluation of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC) programme: a protocol of a cluster randomised control trial. 13:e073585-e073585. 2023
Impact of strategies to mitigate misinformation in diverse settings and populations: a protocol for a living evidence synthesis. 13:e076672-e076672. 2023
TILE pilot trial study protocol: Tinzaparin Lead-in to Prevent the Post-Thrombotic syndrome study protocol. 13:e064715-e064715. 2023
Development of practice-based quality indicators for the primary care of older adults: a RAND/UCLA Appropriateness Method study protocol. 13:e072232-e072232. 2023
Estimating the cost impact of atrial fibrillation using a prospective cohort study and population-based controls. 13:e072080-e072080. 2023
Frequency of postoperative cognitive dysfunction after non-cardiac surgery and its impact on functional outcomes: protocol for a systematic review. 13:e071732-e071732. 2023
One-year real-world outcomes for patients undergoing transcatheter mitral valve repair: the Gulf MTEER registry (GULF Mitral Transcatheter Edge to Edge Repair). 13:e073549-e073549. 2023
Conflict of interest and funding in health communication on social media: a systematic review. 13:e072258-e072258. 2023
Defining the capabilities and competencies of high-performing family physicians: a mixed methods study. 13:e072266-e072266. 2023
Depression, parenting and the COVID-19 pandemic in Canada: results from three nationally representative cross-sectional surveys. 13:e063991-e063991. 2023
For health or for profit? Understanding how private financing and for-profit delivery operate within Canadian healthcare (4H|4P): protocol for a multimethod knowledge mobilisation research project. 13:e077783-e077783. 2023
Patient-reported, health economic and psychosocial outcomes in patients with Friedreich ataxia (PROFA): protocol of an observational study using momentary data assessments via mobile health app. 13:e075736-e075736. 2023
Predictors of harsh parenting practices and inter-partner conflict during the COVID-19 pandemic in Ontario, Canada: a cross-sectional analysis from the Ontario Parent Survey. 13:e066840-e066840. 2023
Protocol for the COVID-19 Wellbeing and Stress Study: a longitudinal study of parent distress, biological stress and child biopsychosocial development during the pandemic and beyond. 13:e071926-e071926. 2023
Doppler identified venous congestion in septic shock: protocol for an international, multi-centre prospective cohort study (Andromeda-VEXUS). 13:e074843-e074843. 2023
Evaluating the impact of including non-randomised studies of interventions in meta-analysis of randomised controlled trials: a protocol for a meta-epidemiological study. 13:e073232-e073232. 2023
Exploring participant attrition in a longitudinal follow-up of older adults: the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort. 13:e066594-e066594. 2023
Identifying priority questions regarding rapid systematic reviews’ methods: protocol for an eDelphi study. 13:e069856-e069856. 2023
Lifestyle changes during the COVID-19 pandemic in Brazil: results from three consecutive cross-sectional web surveys. 13:e070328-e070328. 2023
TeleRehabilitation with Aims to Improve Lower extremity recovery in community-dwelling individuals who have had a stroke: protocol for a multisite, parallel group, assessor-blinded, randomised attention-controlled trial. 13:e076723-e076723. 2023
Critical Care Cycling to ImproveLowerExtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients. 13:e075685-e075685. 2023
Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project). 13:e064498-e064498. 2023
Endovascular thrombectomy with or without thrombolysis bridging in patients with acute ischaemic stroke: protocol for a systematic review, meta-analysis of randomised trials and cost-effectiveness analysis. 13:e064322-e064322. 2023
How regional versus global thresholds for physical activity and grip strength influence physical frailty prevalence and mortality estimates in PURE: a prospective multinational cohort study of community-dwelling adults. 13:e066848-e066848. 2023
Observed intervention effects for mortality in randomised clinical trials: a methodological study protocol. 13:e072550-e072550. 2023
Tolerability of bedtime diuretics: a prospective cohort analysis. 13:e068188-e068188. 2023
A culturally tailored personaliseD nutrition intErvention in South ASIan women at risk of Gestational Diabetes Mellitus (DESI-GDM): a randomised controlled trial protocol. 13:e072353-e072353. 2023
Burden of opioid toxicity death in the fentanyl-dominant era for people who experience incarceration in Ontario, Canada, 2015–2020: a whole population retrospective cohort study. 13:e071867-e071867. 2023
Conversion between B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in perioperative risk assessment: protocol for a prospective cohort study. 13:e068147-e068147. 2023
Nephrologists’ perspectives on the impact of COVID-19 on caring for patients undergoing dialysis in Latin America: a qualitative study. 13:e062321-e062321. 2023
What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives. 13:e070966-e070966. 2023
Cost-utility analysis of a multispecialty interprofessional team dementia care model in Ontario, Canada. 13:e064882-e064882. 2023
Engaging pregnant individuals and healthcare professionals in an international mixed methods study to develop a core outcome set for studies on placenta accreta spectrum disorder (COPAS): a study protocol. 13:e060699-e060699. 2023
Investigating divergent thinking and creative ability in surgeons (IDEAS): a survey protocol. 13:e069873-e069873. 2023
Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures. 13:e073643-e073643. 2023
Older adults’ experiences and perceived impacts of the Aging, Community and Health Research Unit-Community Partnership Program (ACHRU-CPP) for diabetes self-management in Canada: a qualitative descriptive study. 13:e068694-e068694. 2023
Perceptions of COVID-19 risk, vaccine access and confidence: a qualitative description of South Asians in Canada. 13:e070433-e070433. 2023
Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial). 13:e068363-e068363. 2023
What is the role of primary care in the COVID-19 vaccine roll-out and the barriers and facilitators to an equitable vaccine roll-out? A rapid scoping review of nine jurisdictions. 13:e065306-e065306. 2023
Wireless physical activity monitor use among adults living with HIV in a community-based exercise intervention study: a quantitative, longitudinal, observational study. 13:e068754-e068754. 2023
Association of the COVID-19 pandemic on stroke admissions and treatment globally: a systematic review. 13:e062734-e062734. 2023
Can youth-engaged research facilitate equitable access to contraception in Canada? The qualitative study protocol for the Ask Us project. 13:e070904-e070904. 2023
Factors associated with higher quality of clinical practice guidelines and their recommendations for the pharmacological treatment of depression: a systematic review. 13:e067390-e067390. 2023
Piloting an online telecoaching community-based exercise intervention with adults living with HIV: protocol for a mixed-methods implementation science study. 13:e067703-e067703. 2023
Retrospective cross-sectional study examining the association between loneliness and unmet healthcare needs among middle-aged and older adults using the Canadian Longitudinal Study of Aging (CLSA). 13:e068769-e068769. 2023
‘It’s so simple’ Lessons from the margins: a qualitative study of patient experiences of a mobile health clinic in Hamilton, Ontario, Canada. 13:e066674-e066674. 2023
Accuracy of efficient data methods to determine the incidence of hospital-acquired thrombosis and major bleeding in medical and surgical inpatients: a multicentre observational cohort study in four UK hospitals. 13:e069244-e069244. 2023
Association between frailty, chronic conditions and socioeconomic status in community-dwelling older adults attending primary care: a cross-sectional study using practice-based research network data. 13:e066269-e066269. 2023
Critical appraisal and comparison of recommendations of clinical practice guidelines for the treatment of schizophrenia in children and adolescents: a methodological survey. 13:e070332-e070332. 2023
FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate. 13:e067142-e067142. 2023
Global evidence of gender equity in academic health research: a scoping review. 13:e067771-e067771. 2023
High continuous positive airway pressures versus non-invasive positive pressure ventilation in preterm neonates: protocol for a multicentre pilot randomised controlled trial. 13:e069024-e069024. 2023
Examining the immediate and ongoing impact of the COVID-19 pandemic on population-based estimates of dementia: a population-based time series analysis in Ontario, Canada. 13:e067689-e067689. 2023
Mental health and well-being of unpaid caregivers: a cross-sectional survey protocol. 13:e070374-e070374. 2023
Preferences, barriers and facilitators regarding virtual pelvic healthcare in individuals with gynaecological cancers: protocol for a patient-oriented, mixed-methods study. 13:e067606-e067606. 2023
Protocol for validation of the Global Scales for Early Development (GSED) for children under 3 years of age in seven countries. 13:e062562-e062562. 2023
Effects of lifestyle interventions on cardiovascular risk factors in South Asians: a systematic review and meta-analysis. 12:e059666-e059666. 2022
Hospitalised COVID-19 outcomes are predicted by hypoxaemia and pneumonia phenotype irrespective of the timing of their emergence. 12:e062453-e062453. 2022
Income precarity and child and parent weight change during the COVID-19 pandemic: a cross-sectional analysis of the Ontario Parent Survey. 12:e063653-e063653. 2022
Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis. 12:e063023-e063023. 2022
Validation of a classification to identify emergency department visits suitable for subacute and virtual care models: a randomised single-blinded agreement study protocol. 12:e068488-e068488. 2022
Asking youth and adults about child maltreatment: a review of government surveys. 12:e063905-e063905. 2022
Assessing knowledge, attitudes and belief toward HPV vaccination of parents with children aged 9–14 years in rural communities of Northwest Cameroon: a qualitative study. 12:e068212-e068212. 2022
Barriers and facilitators to healthy active living in South Asian families in Canada: a thematic analysis. 12:e060385-e060385. 2022
Characterising performance information use in the primary healthcare systems of El Salvador, Lebanon and Malawi: multiple qualitative case study protocol. 12:e060503-e060503. 2022
Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis. 12:e064060-e064060. 2022
Novel care pathway to optimise antimicrobial prescribing for uncomplicated community-acquired pneumonia: study protocol for a prospective before–after cohort study in the emergency department of a tertiary care Canadian children’s hospital. 12:e062360-e062360. 2022
Canadian Anaphylaxis Network-Predicting Recurrence after Emergency Presentation for Allergic REaction (CAN-PREPARE): a prospective, cohort study protocol. 12:e061976-e061976. 2022
Cross-sectional survey of the Mental health and Addictions effects, Service impacts and Care needs of children, youth and families during the COVID-19 pandemic: the COVID-19 MASC study protocol. 12:e066190-e066190. 2022
Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol. 12:e067117-e067117. 2022
Supporting self-management in women with pre-existing diabetes in pregnancy: a protocol for a mixed-methods sequential comparative case study. 12:e062777-e062777. 2022
Assessing the sensibility and utility of a short-form version of the HIV Disability Questionnaire in clinical practice settings in Canada, Ireland and the USA: a mixed methods study. 12:e062008-e062008. 2022
Pharmacotherapy in paediatric type 2 diabetes mellitus: a protocol for a systematic review and network meta-analysis of randomised trials. 12:e065287-e065287. 2022
Protocol for a qualitative pilot study to explore ethical issues and stakeholder trust in the use of normothermic regional perfusion in organ donation in Canada. 12:e067515-e067515. 2022
South Asian Youth as Vaccine Agents of Change (SAY-VAC): evaluation of a public health programme to mobilise and empower South Asian youth to foster COVID-19 vaccine-related evidence-based dialogue in the Greater Toronto and Hamilton Area, Canada. 12:e061619-e061619. 2022
Understanding patient partnership in health systems: lessons from the Canadian patient partner survey. 12:e061465-e061465. 2022
Understanding patient partnership in health systems: lessons from the Canadian patient partner survey (vol 12, e061465, 2022). 12. 2022
What are the mental health changes associated with the COVID-19 pandemic in people with medical conditions? An international survey. 12:e060995-e060995. 2022
Ku-gaa-gii pimitizi-win, the COVID-19 cohort study of people experiencing homelessness in Toronto, Canada: a study protocol. 12:e063234-e063234. 2022
Cost-free pharmacotherapy in smokers with TIA or stroke: QUIT-MED randomised controlled trial. 12:e050403-e050403. 2022
Factors Associated with the Magnitude Of acUpuncture treatment effectS (FAMOUS): a meta-epidemiological study of acupuncture randomised controlled trials. 12:e060237-e060237. 2022
Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studies. 12:e054282-e054282. 2022
Study protocol for assessing knowledge, attitudes and belief towards HPV vaccination of parents with children aged 9–14 years in rural communities of North West Cameroon: a qualitative study. 12:e062556-e062556. 2022
Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials. 12:e058875-e058875. 2022
How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis. 12:e059561-e059561. 2022
Inclusion of young people with disabilities in the future of work: forecasting workplace, labour market and community-based strategies through an online and accessible Delphi survey protocol. 12:e055452-e055452. 2022
Protocol for a living systematic review for the management of concussion in adults. 12:e061282-e061282. 2022
‘Communication, that is the key’: a qualitative investigation of how essential workers with COVID-19 responded to public health information. 12:e061583-e061583. 2022
Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study. 12:e057991-e057991. 2022
Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study. 12:e056400-e056400. 2022
Development of a core measurement set for research in degenerative cervical myelopathy: a study protocol (AO Spine RECODE-DCM CMS). 12:e060436-e060436. 2022
Evaluation of parent and youth experiences in advisory groups as part of a mental healthcare clinical trial: protocol for a mixed-method study. 12:e059689-e059689. 2022
Evidence mapping and overview of systematic reviews of the effects of acupuncture therapies. 12:e056803-e056803. 2022
Nurturing care during COVID-19: a rapid review of early evidence. 12:e050417-e050417. 2022
Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis. 12:e062428-e062428. 2022
Guidance relevant to the reporting of health equity in observational research: a scoping review protocol. 12:e056875-e056875. 2022
Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP). 12:e058274-e058274. 2022
Personalised immunotherapy in sepsis: a scoping review protocol. 12:e060411-e060411. 2022
Primary care-based integrated disease management for heart failure: a study protocol for a cluster randomised controlled trial. 12:e058608-e058608. 2022
Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit Recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE). 12:e053417-e053417. 2022
Triple-negative breast cancer prevalence in Africa: a systematic review and meta-analysis. 12:e055735-e055735. 2022
Aneurysmal subarachnoid haemorrhage—cerebral vasospasm and prophylactic ibuprofen: a randomised controlled pilot trial protocol. 12:e058895-e058895. 2022
Applying systems thinking to identify enablers and challenges to scale-up interventions for hypertension and diabetes in low-income and middle-income countries: protocol for a longitudinal mixed-methods study. 12:e053122-e053122. 2022
Assessing the impact of mental health difficulties on young people’s daily lives: protocol for a scoping umbrella review of measurement instruments. 12:e054679-e054679. 2022
Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI). 12:e059914-e059914. 2022
Considerations for developing and implementing an online community-based exercise intervention with adults living with HIV: a qualitative study. 12:e059294-e059294. 2022
Effect of obesity treatment interventions in preschool children aged 2–6 years: a systematic review and meta-analysis. 12:e053523-e053523. 2022
Genetics Adviser: a protocol for a mixed-methods randomised controlled trial evaluating a digital platform for genetics service delivery. 12:e060899-e060899. 2022
Impact of quality improvement initiatives to improve CKD referral patterns: a systematic review protocol. 12:e055456-e055456. 2022
Implementation of a new clinical and organisational practice to improve access to primary care services: a protocol for an effectiveness-implementation hybrid study. 12:e059792-e059792. 2022
Implementation strategies to address barriers to evidence-informed symptom management among outpatient oncology nurses: a scoping review protocol. 12:e057661-e057661. 2022
Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial. 12:e056499-e056499. 2022
Prevalence of childhood exposure to intimate partner violence in low-income and lower-middle-income countries: a systematic review. 12:e051140-e051140. 2022
Qualitative study informing the development and content validity of the HAND-Q: a modular patient-reported outcome measure for hand conditions. 12:e052780-e052780. 2022
Responsiveness of the HUG-5 in an outpatient clinic: a 12-month randomised feasibility study protocol. 12:e061057-e061057. 2022
SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: a cross-sectional study. 12:e057846-e057846. 2022
Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials. 12:e048502-e048502. 2022
Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA). 12:e059021-e059021. 2022
Defining decision thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision (EtD) frameworks: a protocol for a randomised methodological study (GRADE-THRESHOLD). 12:e053246-e053246. 2022
Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial. 12:e051907-e051907. 2022
Feasibility of establishing a Canadian Obstetric Survey System (CanOSS) for severe maternal morbidity: a study protocol. 12:e061093-e061093. 2022
Fighting COVID-19: a qualitative study into the lives of intensive care unit survivors in Wuhan, China. 12:e055365-e055365. 2022
Investigating the role and applicability of patient versions of guidelines in oncology and deriving recommendations for the development, dissemination and implementation of patient versions in Germany: protocol for multiphase study. 12:e059040-e059040. 2022
Long COVID and episodic disability: advancing the conceptualisation, measurement and knowledge of episodic disability among people living with Long COVID – protocol for a mixed-methods study. 12:e060826-e060826. 2022
Primary Care Severe Asthma Registry and Education Project (PCSAR-EDU): Phase 1 – an e-Delphi for registry definitions and indices of clinician behaviour. 12:e055958-e055958. 2022
Randomised comparative effectiveness trial of Pulmonary Embolism Prevention after hiP and kneE Replacement (PEPPER): the PEPPER trial protocol. 12:e060000-e060000. 2022
Telerehabilitation for lower extremity recovery poststroke: a systematic review and meta-analysis protocol. 12:e055527-e055527. 2022
Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial. 12:e059711-e059711. 2022
Characteristics and quality of clinical practice guidelines addressing acupuncture interventions: a systematic survey of 133 guidelines and 433 acupuncture recommendations. 12:e058834-e058834. 2022
Comparative efficacy and safety of alternative glucocorticoids regimens in patients with ANCA-associated vasculitis: a systematic review. 12:e050507-e050507. 2022
Cross-sectional prospective feasibility study of newborn screening for sickle cell anaemia and congenital hypothyroidism in Guyana. 12:e046240-e046240. 2022
Development of a core outcome set for multimorbidity trials in low/middle-income countries (COSMOS): study protocol. 12:e051810-e051810. 2022
Families’ healthcare experiences for children with inherited metabolic diseases: protocol for a mixed methods cohort study. 12:e055664-e055664. 2022
Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. 12:e057291-e057291. 2022
Global status of essential medicine selection: a systematic comparison of national essential medicine lists with recommendations by WHO. 12:e053349-e053349. 2022
Impact of virtual care on health-related quality of life in children with diabetes mellitus: a systematic review protocol. 12:e053642-e053642. 2022
Qualitative analysis of a virtual research meeting summarises expert-based strategies to promote hydration in residential care during COVID-19 and beyond. 12:e055457-e055457. 2022
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing liver resection: protocol for the haemorrhage during liver resection tranexamic acid (HeLiX) randomised controlled trial. 12:e058850-e058850. 2022
Understanding income-related differences in distribution of child growth, behaviour and development using a cross-sectional sample of a clinical cohort study. 12:e056991-e056991. 2022
Associations of functional disability and behavioural risk factors with social participation of older adults: a cross-sectional analysis from the Canadian Longitudinal Study on Aging. 12:e052173-e052173. 2022
Clinical outcome measures and their evidence base in degenerative cervical myelopathy: a systematic review to inform a core measurement set (AO Spine RECODE-DCM). 12:e057650-e057650. 2022
Do baseline characteristics and treatments account for geographical disparities in the outcomes of patients with newly diagnosed atrial fibrillation? The prospective GARFIELD-AF registry. 12:e049933-e049933. 2022
Evaluation of a decision aid for incidental genomic results, the Genomics ADvISER: protocol for a mixed methods randomised controlled trial. 8:e021876-e021876. 2022
Investigating the work–life experiences of nursing faculty in Canadian academic settings and the factors that influence their retention: protocol for a mixed-method study. 12:e056655-e056655. 2022
Sacrifice and solidarity: a qualitative study of family experiences of death and bereavement in critical care settings during the pandemic. 12:e058768-e058768. 2022
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study. 11:e052019-e052019. 2021
CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19. 11:e055832-e055832. 2021
CCWORK protocol: a longitudinal study of Canadian Correctional Workers’ Well-being, Organizations, Roles and Knowledge. 11:e052739-e052739. 2021
Current practices and challenges in adaptation of clinical guidelines: a qualitative study based on semistructured interviews. 11:e053587-e053587. 2021
Detecting young people with mental disorders: a cluster-randomised trial of multidisciplinary health teams at the GP office. 11:e050036-e050036. 2021
Functional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal cohort study. 11:e053021-e053021. 2021
Identifying patient characteristics associated with potentially redirectable paramedic transported emergency department visits in Ontario, Canada: a population-based cohort study. 11:e054625-e054625. 2021
Identifying patient-important outcomes for treatment of bipolar disorder: a systematic review protocol. 11:e050453-e050453. 2021
Impact of COVID-19 on mobility and participation of older adults living in Hamilton, Ontario, Canada: a multimethod cohort design protocol. 11:e053758-e053758. 2021
Public health implications of SARS-CoV-2 variants of concern: a rapid scoping review. 11:e055781-e055781. 2021
Association of chiropractic integration in an Ontario community health centre with prescription opioid use for chronic non-cancer pain: a mixed methods study protocol. 11:e051000-e051000. 2021
Kukaa Salama (Staying Safe): study protocol for a pre/post-trial of an interactive mHealth intervention for increasing COVID-19 prevention practices with urban refugee youth in Kampala, Uganda. 11:e055530-e055530. 2021
Optimising a couples-focused intervention to increase couples’ HIV testing and counselling using the person-based approach: a qualitative study in Kwa-Zulu Natal, South Africa. 11:e047408-e047408. 2021
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study. 11:e050830-e050830. 2021
Outcomes reported in randomised controlled trials of major depressive disorder in older adults: protocol for a methodological review. 11:e054777-e054777. 2021
Quality indicators for transition from paediatric to adult care for adolescents with chronic physical and mental illness: protocol for a systematic review. 11:e055194-e055194. 2021
Rates of opioid agonist treatment prescribing in provincial prisons in Ontario, Canada, 2015–2018: a repeated cross-sectional analysis. 11:e048944-e048944. 2021
Relevance of assessment items in community paramedicine home visit programmes: results of a modified Delphi study. 11:e048504-e048504. 2021
Trajectory research in children on the autism spectrum: a scoping review protocol. 11:e053443-e053443. 2021
Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol. 11:e055630-e055630. 2021
Gastrointestinal recovery after surgery: protocol for a systematic review. 11:e054704-e054704. 2021
Impact of electronic cigarette ever use on lung function in adults aged 45–85: a cross-sectional analysis from the Canadian Longitudinal Study on Aging. 11:e051519-e051519. 2021
Relationship between hormonal contraceptives and sleep among women of reproductive age: a systematic review protocol. 11:e045819-e045819. 2021
Values and other decisional factors regarding treatment of hypercalcaemia of malignancy: a systematic review protocol. 11:e051141-e051141. 2021
Virological measures and factors associated with outcomes, and missing outcome data in HIV clinical trials: a methodological study. 11:e039462-e039462. 2021
Youth in a pandemic: a longitudinal examination of youth mental health and substance use concerns during COVID-19. 11:e049209-e049209. 2021
Cohort profile: the Ontario Life After Workplace Injury Study (OLAWIS). 11:e048143-e048143. 2021
Diagnostic and prognostic accuracy of Protein C in adult patients with sepsis: protocol for a systematic review and meta-analysis. 11:e050754-e050754. 2021
Health programmes and services addressing the prevention and management of infectious diseases in people who inject drugs in Canada: a systematic integrative review. 11:e047511-e047511. 2021
Impact of restricted visitation policies in hospitals on patients, family members and healthcare providers during the COVID-19 pandemic: a scoping review protocol. 11:e048227-e048227. 2021
Investigating and addressing the immediate and long-term consequences of the COVID-19 pandemic on patients with substance use disorders: a scoping review and evidence map protocol. 11:e045946-e045946. 2021
Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic. 11:e047175-e047175. 2021
MUFFIN-PTS trial, Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome: protocol of a randomised controlled trial. 11:e049557-e049557. 2021
Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial). 11:e051003-e051003. 2021
Publication practices of sub-Saharan African Cochrane authors: a bibliometric study. 11:e051839-e051839. 2021
Ross for Valve replacement In AduLts (REVIVAL) pilot trial: rationale and design of a randomised controlled trial. 11:e046198-e046198. 2021
Values and preferences towards medical cannabis among people living with chronic pain: a mixed-methods systematic review. 11:e050831-e050831. 2021
Adverse events associated with endoscopic retrograde cholangiopancreatography: protocol for a systematic review and meta-analysis. 11:e053302-e053302. 2021
Identifying non-traditional electronic datasets for population-level surveillance and prevention of cardiometabolic diseases: a scoping review protocol. 11:e053485-e053485. 2021
Intimate partner violence (IPV) in male and female orthopaedic trauma patients: a multicentre, cross-sectional prevalence study. 11:e046164-e046164. 2021
Single-centre, open-label, randomised, trial to compare rapid molecular point-of-care streptococcal testing to standard laboratory-based testing for the management of streptococcal pharyngitis in children: study protocol. 11:e047271-e047271. 2021
Sleep, biological rhythms and anxiety in the perinatal period: a systematic review protocol. 11:e046767-e046767. 2021
COVID-19 international border surveillance at Toronto’s Pearson Airport: a cohort study. 11:e050714-e050714. 2021
Coached, Coordinated, Enhanced Neonatal Transition (CCENT): protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants. 11:e046706-e046706. 2021
Consideration of antimicrobial resistance and contextual factors in infectious disease guidelines: a systematic survey. 11:e046097-e046097. 2021
Experiences engaging in a group-based physiotherapist-led exercise programme for adults living with HIV and complex multimorbidity: a qualitative study. 11:e045158-e045158. 2021
Frailty differences across population characteristics associated with health inequality: a cross-sectional analysis of baseline data from the Canadian Longitudinal Study on Aging (CLSA). 11:e047945-e047945. 2021
Hands-Up program: protocol for a feasibility randomised controlled trial of a combined 6-week exercise and education intervention in adults aged 50–65 with a distal radius fracture. 11:e046122-e046122. 2021
Interventional treatments for chronic, axial or radicular, non-cancer, spinal pain: a protocol for a systematic review and network meta-analysis of randomised trials. 11:e046025-e046025. 2021
Management of social isolation and loneliness in community-dwelling older adults: protocol for a network meta-analysis of randomised controlled trials. 11:e042828-e042828. 2021
Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies. 11:e047717-e047717. 2021
Programmes to prepare siblings for future roles to support their brother or sister with a neurodisability: protocol of a scoping review. 11:e053184-e053184. 2021
Risk assessment models for venous thromboembolism in hospitalised adult patients: a systematic review. 11:e045672-e045672. 2021
Simulation study on the validity of the average risk approach in estimating population attributable fractions for continuous exposures. 11:e045410-e045410. 2021
Systematic review of academic bullying in medical settings: dynamics and consequences. 11:e043256-e043256. 2021
Values, preferences and burden of treatment for the initiation of GLP-1 receptor agonists and SGLT-2 inhibitors in adult patients with type 2 diabetes: a systematic review. 11:e049130-e049130. 2021
Which older emergency patients are at risk of intracranial bleeding after a fall? A protocol to derive a clinical decision rule for the emergency department. 11:e044800-e044800. 2021
Mixed-methods study protocol for an evaluation of the mental health transition navigator model in child and adolescent mental health services: the Navigator Evaluation Advancing Transitions (NEAT) study. 11:e051190-e051190. 2021
Progression from external pilot to definitive randomised controlled trial: a methodological review of progression criteria reporting. 11:e048178-e048178. 2021
Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units. 11:e046909-e046909. 2021
Association between end-of-life cancer care and immigrant status: a retrospective cohort study in Ontario, Canada. 11:e042978-e042978. 2021
Impact of disasters, including pandemics, on cardiometabolic outcomes across the life-course: a systematic review. 11:e047152-e047152. 2021
LIVES for families psychological first aid training programme to address COVID-19 psychological distress: A mixed methods acceptability and feasibility protocol. 11:e049995-e049995. 2021
Physical-mental multimorbidity in children and youth: a scoping review. 11:e043124-e043124. 2021
Transforming primary care for older Canadians living with frailty: mixed methods study protocol for a complex primary care intervention. 11:e042911-e042911. 2021
Association between postsurgical pain and heart rate variability: protocol for a scoping review. 11:e044949-e044949. 2021
Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol. 11:e046851-e046851. 2021
Determinants of short birth intervals among married women: a cross-sectional study in Karachi, Pakistan. 11:e043786-e043786. 2021
Impact of neighbourhood walkability on the onset of multimorbidity: a cohort study. 11:e045890-e045890. 2021
Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE). 11:e049093-e049093. 2021
Virtual care for prostate cancer survivorship: protocol for an evaluation of a nurse-led algorithm-enhanced virtual clinic implemented at five cancer centres across Canada. 11:e045806-e045806. 2021
Web-based early intervention for children with motor difficulties aged 3–8 years old using multimodal rehabilitation (WECARE): protocol of a patient-centred pragmatic randomised trial of paediatric telerehabilitation to support families. 11:e046561-e046561. 2021
CHILD-BRIGHT READYorNot Brain-Based Disabilities Trial: protocol of a randomised controlled trial (RCT) investigating the effectiveness of a patient-facing e-health intervention designed to enhance healthcare transition readiness in youth. 11:e048756-e048756. 2021
Decision Analysis in SHared decision making for Thromboprophylaxis during Pregnancy (DASH-TOP): a sequential explanatory mixed methods pilot study protocol. 11:e046021-e046021. 2021
HIV prevention and treatment interventions for black men who have sex with men in Canada: a protocol for a scoping systematic review. 11:e043055-e043055. 2021
Repetitive transcranial magnetic stimulation alone and in combination with motor control exercise for the treatment of individuals with chronic non-specific low back pain (ExTraStim trial): study protocol for a randomised controlled trial. 11:e045504-e045504. 2021
Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: a systematic review. 11:e040616-e040616. 2021
Staying ahead of the curve: Navigating changes and maintaining gains in patient safety culture - a mixed-methods study. 11:e044116-e044116. 2021
Deprescribing fall-risk increasing drugs (FRIDs) for the prevention of falls and fall-related complications: a systematic review and meta-analysis. 11:e035978-e035978. 2021
Do premorbid characteristics of home care clients predict delayed discharges in acute care hospitals: a retrospective cohort study in Ontario and British Columbia, Canada. 11:e038484-e038484. 2021
End-of-life outcomes with or without early palliative care: a propensity score matched, population-based cancer cohort study. 11:e041432-e041432. 2021
Patient-specific instrumentation (PSI) Referencing High Tibial Osteotomy Technological Transfer and Education: protocol for a double-blind, randomised controlled trial (PROTECTED HTO Trial). 11:e041129-e041129. 2021
Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN): a Healthy Life Trajectories Initiative (HeLTI) Study. 11:e045862-e045862. 2021
Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada). 11:e046311-e046311. 2021
Willingness of patients with sarcoma to participate in cancer surveillance research: a cross-sectional patient survey. 11:e042742-e042742. 2021
Disclosure of study funding and author conflicts of interest in press releases and the news: a retrospective content analysis with two cohorts.. 11:e041385. 2021
Are patients’ goals in treatment associated with expected treatment outcomes? Findings from a mixed-methods study on outpatient pharmacological treatment for opioid use disorder. 11:e044017-e044017. 2021
Association between vaping and health outcomes in patients with opioid use disorder: a systematic review protocol. 11:e040349-e040349. 2021
Barriers, facilitators, preferences and expectations of joint protection programmes for patients with hand arthritis: a cross-sectional survey. 11:e041935-e041935. 2021
Development of the PriCARE classification for potentially preventable emergency department visits by ambulance: a RAND/UCLA modified Delphi study protocol. 11:e045351-e045351. 2021
Which Exercise for Low Back Pain? (WELBack) trial predicting response to exercise treatments for patients with low back pain: a validation randomised controlled trial protocol. 11:e042792-e042792. 2021
Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol. 10:e041319-e041319. 2020
Establishing thresholds for important benefits considering the harms of screening interventions. 10:e037854-e037854. 2020
How do cancer screening guidelines trade off benefits versus harms and burdens of screening? A systematic survey. 10:e038322-e038322. 2020
Introduction to statistical simulations in health research. 10:e039921-e039921. 2020
National primary care responses to COVID-19: a rapid review of the literature. 10:e041622-e041622. 2020
Protocol for a scoping review of outcomes in clinical studies of interventions for venous thromboembolism in adults. 10:e040122-e040122. 2020
Reporting of methodological studies in health research: a protocol for the development of the MethodologIcal STudy reportIng Checklist (MISTIC). 10:e040478-e040478. 2020
Are you really doing ‘codesign’? Critical reflections when working with vulnerable populations. 10:e038339-e038339. 2020
Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial. 10:e040110-e040110. 2020
Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial. 10:e037947-e037947. 2020
Use of implementation science in tobacco control intervention studies in the USA between 2000 and 2020: a scoping review protocol. 10:e038617-e038617. 2020
Cost-effectiveness analysis of a community paramedicine programme for low-income seniors living in subsidised housing: the community paramedicine at clinic programme (CP@clinic). 10:e037386-e037386. 2020
IMAGINE Network’s Mind And Gut Interactions Cohort (MAGIC) Study: a protocol for a prospective observational multicentre cohort study in inflammatory bowel disease and irritable bowel syndrome. 10:e041733-e041733. 2020
Identifying factors associated with high use of acute care in Canada: protocol of a population-based retrospective cohort study. 10:e038008-e038008. 2020
Predicting population health with machine learning: a scoping review. 10:e037860-e037860. 2020
Reproductive patterns, pregnancy outcomes and parental leave practices of women physicians in Ontario, Canada: the Dr Mom Cohort Study protocol. 10:e041281-e041281. 2020
Social determinants of health associated with the development of sepsis in adults: a scoping review protocol. 10:e039146-e039146. 2020
Trial of remote ischaemic preconditioning in vascular cognitive impairment (TRIC-VCI): protocol. 10:e040466-e040466. 2020
Critical review of multimorbidity outcome measures suitable for low-income and middle-income country settings: perspectives from the Global Alliance for Chronic Diseases (GACD) researchers. 10:e037079-e037079. 2020
How and why a multifaceted intervention to improve adherence post-MI worked for some (and could work better for others): an outcome-driven qualitative process evaluation. 10:e036750-e036750. 2020
Impact of COVID-19 and other pandemics and epidemics on people with pre-existing mental disorders: a systematic review protocol and suggestions for clinical care. 10:e040229-e040229. 2020
Impact of home-based family planning counselling and referral on modern contraceptive use in Karachi, Pakistan: a retrospective, cross-sectional matched control study. 10:e039835-e039835. 2020
Multicentre, single-blind randomised controlled trial comparing MyndMove neuromodulation therapy with conventional therapy in traumatic spinal cord injury: a protocol study. 10:e039650-e039650. 2020
Overview of systematic reviews on strategies to improve treatment initiation, adherence to antiretroviral therapy and retention in care for people living with HIV: part 1. 10:e034793-e034793. 2020
Predictors of oral anticoagulant-associated adverse events in seniors transitioning from hospital to home: a retrospective cohort study protocol. 10:e036537-e036537. 2020
Adaptive design methods in dialysis clinical trials: a systematic review protocol. 10:e036755-e036755. 2020
Barriers and facilitators to optimal supportive end-of-life palliative care in long-term care facilities: a qualitative descriptive study of community-based and specialist palliative care physicians’ experiences, perceptions and perspectives. 10:e037466-e037466. 2020
Barriers in accessing HIV care for Francophone African, Caribbean and Black people living with HIV in Canada: a scoping review. 10:e036885-e036885. 2020
Do insomnia and/or sleep disturbances predict the onset, relapse or worsening of depression in community and clinical samples of children and youth? Protocol for a systematic review and meta-analysis. 10:e034606-e034606. 2020
Health programmes and services addressing the prevention and management of infectious diseases in persons who inject drugs in Canada: a systematic integrative review protocol. 10:e035188-e035188. 2020
Protocol of an interdisciplinary consensus project aiming to develop an AGREE II extension for guidelines in surgery. 10:e037107-e037107. 2020
A/C study protocol: a cross-sectional study of HIV epidemiology among African, Caribbean and Black people in Ontario. 10:e036259-e036259. 2020
Cardiac donation after circulatory determination of death: protocol for a mixed-methods study of healthcare provider and public perceptions in Canada. 10:e033932-e033932. 2020
Core outcome set for studies on pregnant women with vasa previa (COVasP): a study protocol. 10:e034018-e034018. 2020
Development of a core outcome set for studies on prevention and management of pregnancy-associated venous thromboembolism (COSPVenTE): a study protocol. 10:e034017-e034017. 2020
National suicide management guidelines with family as an interv’ention and suicide mortality rates: a systematic review protocol. 10:e034694-e034694. 2020
Provision of medical assistance in dying: a scoping review. 10:e036054-e036054. 2020
Reporting of conflicts of interest by authors of primary studies on health policy and systems research: a cross-sectional survey. 10:e032425-e032425. 2020
Systematic survey of the causal language use in systematic reviews of observational studies: a study protocol. 10:e038571-e038571. 2020
Trajectories of health system use and survival for community-dwelling persons with dementia: a cohort study. 10:e037485-e037485. 2020
Assessing the transparency of informed consent in feasibility and pilot studies: a single-centre quality assurance study protocol. 10:e036226-e036226. 2020
Concurrent validity of the alcohol purchase task in relation to alcohol involvement: protocol for a systematic review and meta-analysis. 10:e035400-e035400. 2020
Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol. 10:e036047-e036047. 2020
How have predictors, moderators, mediators, treatment response, remission and resistance been defined and measured in randomised controlled trials for adolescent depression? A scoping review protocol. 10:e036171-e036171. 2020
Improving gender equity in critical care medicine: a protocol to establish priorities and strategies for implementation. 10:e037090-e037090. 2020
Patient-centred and family-centred care of critically ill patients who are potential organ donors: a qualitative study protocol of family member perspectives. 10:e037527-e037527. 2020
Psychometric properties of an Arabic-language health literacy assessment scale for adolescents (HAS-A-AR) in Palestine. 10:e034943-e034943. 2020
Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study). 10:e035177-e035177. 2020
Assessing care models implemented in primary healthcare for persons with dementia: a mixed-methods study protocol. 10:e035916-e035916. 2020
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) randomised clinical trial: study protocol. 10:e038300-e038300. 2020
Characteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey. 10:e034565-e034565. 2020
Cow’s Milk Fat Obesity pRevention Trial (CoMFORT): a primary care embedded randomised controlled trial protocol to determine the effect of cow’s milk fat on child adiposity. 10:e035241-e035241. 2020
Collaborating with healthcare providers to understand their perspectives on a hospital-to-home warning signs intervention for rural transitional care: protocol of a multimethod descriptive study. 10:e034698-e034698. 2020
Socioeconomic gradient in the developmental health of Canadian children with disabilities at school entry: a cross-sectional study. 10:e032396-e032396. 2020
[¹⁸F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial. 10:e035959-e035959. 2020
Development and usability testing of HEARTPA♀N: protocol for a mixed methods strategy to develop an integrated smartphone and web-based intervention for women with cardiac pain. 10:e033092-e033092. 2020
Evaluating a group-based Yoga of Stress Resilience programme: a pragmatic before–after interventional study protocol. 10:e035862-e035862. 2020
Impact of a short version of the CONSORT checklist for peer reviewers to improve the reporting of randomised controlled trials published in biomedical journals: study protocol for a randomised controlled trial. 10:e035114-e035114. 2020
International mixed methods study protocol to develop a patient-reported outcome measure for all types of chronic wounds (the WOUND-Q). 10:e032332-e032332. 2020
Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial. 10:e037251-e037251. 2020
Chronic disease management models in nursing homes: a scoping review. 10:e032316-e032316. 2020
Impact of the KidneyWise toolkit on chronic kidney disease referral practices in Ontario primary care: a prospective evaluation. 10:e032838-e032838. 2020
Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18. 10:e035744-e035744. 2020
Developing a framework to incorporate real-world evidence in cancer drug funding decisions: the Canadian Real-world Evidence for Value of Cancer Drugs (CanREValue) collaboration. 10:e032884-e032884. 2020
Effectiveness of non-pharmacological strategies in the management of type 2 diabetes in primary care: a protocol for a systematic review and network meta-analysis. 10:e034481-e034481. 2020
Guidelines about physical activity and exercise to reduce cardiometabolic risk factors: protocol for a systematic review and critical appraisal. 10:e032656-e032656. 2020
International phase 1 study protocol to develop a health state classification system for a preference-based measure for women with breast cancer: the BREAST-Q Utility module. 10:e034451-e034451. 2020
Sex-specific effects of nutritional supplements in infants born early or small: protocol for an individual participant data meta-analysis (ESSENCE IPD-MA). 10:e033438-e033438. 2020
Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study. 9:e035206-e035206. 2019
DIVERT-Collaboration Action Research and Evaluation (CARE) Trial Protocol: a multiprovincial pragmatic cluster randomised trial of cardiorespiratory management in home care. 9:e030301-e030301. 2019
Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol. 9:e034594-e034594. 2019
Role of patient preferences in clinical practice guidelines: a multiple methods study using guidelines from oncology as a case. 9:e032483-e032483. 2019
Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis. 9:e031895-e031895. 2019
Sleep duration and eating behaviours in youth: a scoping review protocol. 9:e030457-e030457. 2019
Transitional care quality indicators to assess quality of care following hospitalisation for chronic obstructive pulmonary disease and heart failure: a systematic review protocol. 9:e032764-e032764. 2019
Estimation of fibrosis progression rates for chronic hepatitis C: a systematic review and meta-analysis update. 9:e027491-e027491. 2019
Fit for School Study protocol: early child growth, health behaviours, nutrition, cardiometabolic risk and developmental determinants of a child’s school readiness, a prospective cohort. 9:e030709-e030709. 2019
Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care. 9:e029810-e029810. 2019
Multifaceted intervention to Reduce Antimicrobial Prescribing in Care Homes: a process evaluation of a UK-based non-randomised feasibility study. 9:e032185-e032185. 2019
Multimorbidity in Children and Youth Across the Life-course (MY LIFE): protocol of a Canadian prospective study. 9:e034544-e034544. 2019
Protocol for a double-blind, randomised, placebo-controlled pilot study for assessing the feasibility and efficacy of faecal microbiota transplant in a paediatric Crohn’s disease population: PediCRaFT Trial. 9:e030120-e030120. 2019
Psychometric properties of the global rating of change scales in patients with neck disorders: a systematic review with meta-analysis and meta-regression. 9:e033909-e033909. 2019
Systematic review of the measurement properties of performance-based functional tests in patients with neck disorders. 9:e031242-e031242. 2019
Examining consensus for a standardised patient assessment in community paramedicine home visits: a RAND/UCLA-modified Delphi Study. 9:e031956-e031956. 2019
Feasibility and implementation of a healthy lifestyles program in a community setting in Ontario, Canada: protocol for a pragmatic mixed methods pilot study. 9:e031298-e031298. 2019
Incremental healthcare utilisation and costs among new senior high-cost users in Ontario, Canada: a retrospective matched cohort study. 9:e028637-e028637. 2019
Optimised transcranial direct current stimulation (tDCS) for fibromyalgia—targeting the endogenous pain control system: a randomised, double-blind, factorial clinical trial protocol. 9:e032710-e032710. 2019
Regional variation in primary care improvement strategies and policy: case studies that consider qualitative contextual data for performance measurement in three Canadian provinces. 9:e029622-e029622. 2019
Understanding data and information needs for palliative cancer care to inform digital health intervention development in Nigeria, Uganda and Zimbabwe: protocol for a multicountry qualitative study. 9:e032166-e032166. 2019
Choosing appropriate tools and referral criteria for vision screening of children aged 4–5 years in Canada: a quantitative analysis. 9:e032138-e032138. 2019
Cohort profile: the Canadian coordination and activity tracking in children (CATCH) longitudinal cohort. 9:e029784-e029784. 2019
Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis. 9:e030407-e030407. 2019
Decision support intervention (Plan Well Guide) for patients and their substitute decision-makers to improve engagement in advance care planning: protocol for a randomised trial. 9:e027897-e027897. 2019
Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial. 9:e033150-e033150. 2019
Empirical evaluation of SUCRA-based treatment ranks in network meta-analysis: quantifying robustness using Cohen’s kappa. 9:e024625-e024625. 2019
Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol. 9:e030092-e030092. 2019
Extending the RIGHT statement for reporting adapted practice guidelines in healthcare: the RIGHT-Ad@pt Checklist protocol. 9:e031767-e031767. 2019
Risk of myocardial infarction among people living with HIV: an updated systematic review and meta-analysis. 9:e025874-e025874. 2019
The Surveillance After Extremity Tumor Surgery (SAFETY) trial: protocol for a pilot study to determine the feasibility of a multi-centre randomised controlled trial. 9:e029054-e029054. 2019
Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol). 9:e028585-e028585. 2019
Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. 9:e031775-e031775. 2019
Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity. 9:e028121-e028121. 2019
Educational virtual reality videos in improving bowel preparation quality and satisfaction of outpatients undergoing colonoscopy: protocol of a randomised controlled trial. 9:e029483-e029483. 2019
Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial. 9:e024968-e024968. 2019
Living strategies for disability in men ageing with HIV in Ontario, Canada: a longitudinal qualitative study. 9:e031262-e031262. 2019
Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database. 9:e029667-e029667. 2019
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients (COMIC): a pilot randomised controlled trial protocol. 9:e029394-e029394. 2019
Development of a point of care system for automated coma prognosis: a prospective cohort study protocol. 9:e029621-e029621. 2019
Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. 9:e027893-e027893. 2019
Women with physical disability in pregnancy resident education: a national survey as a needs assessment for curriculum improvement in obstetrics and gynaecology in Canada. 9:e024505-e024505. 2019
Nash-wo-Numa(childhood growth & development) study protocol: factors that impact linear growth in children 9 to 15 years of age in Matiari, Pakistan. 9:e028343-e028343. 2019
DONORS (Donation Network to Optimise Organ Recovery Study): Study protocol to evaluate the implementation of an evidence-based checklist for brain-dead potential organ donor management in intensive care units, a cluster randomised trial. 9:e028570-e028570. 2019
Defining certainty of net benefit: a GRADE concept paper. 9:e027445-e027445. 2019
Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study. 9:e028237-e028237. 2019
Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT. 9:e025228-e025228. 2019
Impact of smoking on health system costs among cancer patients in a retrospective cohort study in Ontario, Canada. 9:e026022-e026022. 2019
Perceptions of older adults in Ontario, Canada on the implementation and impact of a primary care programme, Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY): a descriptive qualitative study. 9:e026257-e026257. 2019
Psychological correlates and binge drinking behaviours among Canadian youth: a cross-sectional analysis of the mental health pilot data from the COMPASS study. 9:e028558-e028558. 2019
Public, health professional and legislator perspectives on the concept of psychiatric disease: a population-based survey. 9:e024265-e024265. 2019
A methodological survey on reporting of pilot and feasibility trials for physiotherapy interventions: a study protocol. 9:e020580-e020580. 2019
Accounting for health literacy and intervention preferences when reducing unhealthy snacking: protocol for an online randomised controlled trial. 9:e028544-e028544. 2019
Acute and long-term clinical, neuropsychological and return-to-work sequelae following electrical injury: a retrospective cohort study. 9:e025990-e025990. 2019
Anti-vascular endothelial growth factor treatment for retinal conditions: a systematic review and meta-analysis. 9:e022031-e022031. 2019
Effect of cervical manipulation on vertebral artery and cerebral haemodynamics in patients with chronic neck pain: a crossover randomised controlled trial. 9:e025219-e025219. 2019
Effectiveness of interventions for the implementation of thromboprophylaxis in hospitalised patients at risk of venous thromboembolism: an updated abridged Cochrane systematic review and meta-analysis of randomised controlled trials. 9:e024444-e024444. 2019
Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials. 9:e023729-e023729. 2019
Important food sources of fructose-containing sugars and incident gout: a systematic review and meta-analysis of prospective cohort studies. 9:e024171-e024171. 2019
International multiphase mixed methods study protocol to develop a patient-reported outcome instrument for children and adolescents with lower limb deformities. 9:e027079-e027079. 2019
Investigating the stratified efficacy and safety of pharmacological blood pressure-lowering: an overall protocol for individual patient-level data meta-analyses of over 300 000 randomised participants in the new phase of the Blood Pressure Lowering Treatment Trialists’ Collaboration (BPLTTC). 9:e028698-e028698. 2019
Pedagogical strategies in teaching invasive prenatal procedures: a scoping review protocol. 9:e024629-e024629. 2019
Perioperative Pain and Addiction Interdisciplinary Network (PAIN): protocol of a practice advisory for the perioperative management of buprenorphine using a modified Delphi process. 9:e027374-e027374. 2019
Recommendations for integrating physiotherapy into an interprofessional outpatient care setting for people living with HIV: a qualitative study. 9:e026827-e026827. 2019
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. 9:e025728-e025728. 2019
Children’s and caregivers’ perspectives about mandatory reporting of child maltreatment: a meta-synthesis of qualitative studies. 9:e025741-e025741. 2019
How do financial (dis)incentives influence health behaviour and costs? Protocol for a systematic literature review of randomised controlled trials. 9:e024694-e024694. 2019
Management of acute musculoskeletal pain (excluding low back pain): protocol for a systematic review and network meta-analysis of randomised trials. 9:e024441-e024441. 2019
Multifactorial correlates of blood pressure in South Asian children in Canada: a cross-sectional study. 9:e027844-e027844. 2019
Qualitative descriptive study to explore nurses’ perceptions and experience on pain, agitation and delirium management in a community intensive care unit. 9:e024328-e024328. 2019
Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients. 9:e028537-e028537. 2019
What factors are associated with resilient outcomes in children exposed to social adversity? A systematic review. 9:e024870-e024870. 2019
Barriers and facilitators to adopting high value practices and de-adopting low value practices in Canadian intensive care units: a multimethod study. 9:e024159-e024159. 2019
Children and Teens in Charge of their Health (CATCH): A protocol for a feasibility randomised controlled trial of solution-focused coaching to foster healthy lifestyles in childhood disability. 9:e025119-e025119. 2019
Effectiveness of the Diagnose-Intervene- Verify-Adjust (DIVA) model for integrated primary healthcare planning and performance improvement: an embedded mixed methods evaluation in Kaduna state, Nigeria. 9:e026016-e026016. 2019
Experiences of community-dwelling older adults living with multiple chronic conditions: a qualitative study. 9:e023345-e023345. 2019
International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome and experience measure for hand conditions (HAND-Q). 9:e025822-e025822. 2019
Patient trade-offs between continuity and access in primary care interprofessional teaching clinics in Canada: a cross-sectional survey using discrete choice experiment. 9:e023578-e023578. 2019
The ART of conversation: feasibility and acceptability of a pilot peer intervention to help transition complex HIV-positive people from hospital to community. 9:e026674-e026674. 2019
Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study. 9:e024087-e024087. 2019
Comparative risk of new-onset diabetes following commencement of antipsychotics in New Zealand: a population-based clustered multiple baseline time series design. 9:e022984-e022984. 2019
Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study. 9:e022995-e022995. 2019
Minimal important differences for improvement in shoulder condition patient-reported outcomes: a systematic review to inform aBMJRapid Recommendation. 9:e028777-e028777. 2019
Multimorbidity, eHealth and implications for equity: a cross-sectional survey of patient perspectives on eHealth. 9:e023731-e023731. 2019
Quality of reporting of outcomes in trials of therapeutic interventions for pressure ulcers in adults: a protocol for a systematic survey. 9:e024633-e024633. 2019
Shortening patient-reported outcome measures through optimal test assembly: application to the Social Appearance Anxiety Scale in the Scleroderma Patient-centered Intervention Network Cohort. 9:e024010-e024010. 2019
Barriers to HIV care among Francophone African, Caribbean and Black immigrant people living with HIV in Canada: a protocol for a scoping systematic review. 9:e027440-e027440. 2019
Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study]. 9:e023540-e023540. 2019
Health-related quality of life and anxiety in the PAN-CAN lung cancer screening cohort. 9:e024719-e024719. 2019
Large care gaps in primary care management of asthma: a longitudinal practice audit. 9:e022506-e022506. 2019
Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery. 9:e023455-e023455. 2019
Outcomes reported in randomised clinical trials of major depressive disorder treatments in adolescents: a systematic scoping review protocol. 9:e024191-e024191. 2019
Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: a population-based study. 9:e023004-e023004. 2019
Feasibility and validity of the Health Status Classification System-Preschool (HSCS-PS) in a large community sample: the Generation R study. 8:e022449-e022449. 2018
Identifying patient-important outcomes in medication-assisted treatment for opioid use disorder patients: a systematic review protocol. 8:e025059-e025059. 2018
Case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs: an implementation and realist evaluation protocol. 8:e026433-e026433. 2018
Acupuncture treatment for knee osteoarthritis with sensitive points: protocol for a multicentre randomised controlled trial. 8:e023838-e023838. 2018
International phase I study protocol to develop a patient-reported outcome measure for adolescents and adults receiving gender-affirming treatments (the GENDER-Q). 8:e025435-e025435. 2018
Strategies to improve adherence to antiretroviral therapy and retention in care for people living with HIV in high-income countries: a protocol for an overview of systematic reviews. 8:e022982-e022982. 2018
Values and preferences of men for undergoing prostate-specific antigen screening for prostate cancer: a systematic review. 8:e025470-e025470. 2018
Correction: Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: a systematic review and network meta-analysis incorporating complementary external evidence.. 8:e023761corr1. 2018
Does perturbation-based balance training prevent falls among individuals with chronic stroke? A randomised controlled trial. 8:e021510-e021510. 2018
FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial. 8:e022780-e022780. 2018
Protocol for a scoping review about ethics in transition programmes for adolescents and young adults with neurodisabilities. 8:e020914-e020914. 2018
Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data. 8:e025266-e025266. 2018
Psychometric properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire. 8:e021900-e021900. 2018
Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial. 8:e020941-e020941. 2018
Defining and measuring health equity effects in research on task shifting interventions in high-income countries: a systematic review protocol. 8:e021172-e021172. 2018
Estimating the current and future cancer burden in Canada: methodological framework of the Canadian population attributable risk of cancer (ComPARe) study. 8:e022378-e022378. 2018
Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: a systematic review and network meta-analysis incorporating complementary external evidence. 8:e023761-e023761. 2018
Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study. 8:e021521-e021521. 2018
Overweight and obesity management strategies in survivors of paediatric acute lymphoblastic leukaemia: a systematic review protocol. 8:e022530-e022530. 2018
POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil. 8:e021170-e021170. 2018
Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone. 8:e022504-e022504. 2018
Correction:Values and preferences of women living with HIV who are pregnant, postpartum or considering pregnancy on choice of antiretroviral therapy during pregnancy. 8:e019023corr1-e019023corr1. 2018
Establishing a protocol for building a pan-Canadian population-based monitoring system for early childhood development for children with health disorders: Canadian Children’s Health in Context Study (CCHICS). 8:e023688-e023688. 2018
Multimorbidity in children and youth: a scoping review protocol. 8:e022413-e022413. 2018
A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer. 8:e020298-e020298. 2018
Access to palliative care by disease trajectory: a population-based cohort of Ontario decedents. 8:e021147-e021147. 2018
Identification and initial response to children’s exposure to intimate partner violence: a qualitative synthesis of the perspectives of children, mothers and professionals. 8:e019761-e019761. 2018
Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial. 8:e022707-e022707. 2018
Pathways of association between maternal haemoglobin and stillbirth: path-analysis of maternity data from two hospitals in England. 8:e020149-e020149. 2018
Patient preferences for nutritional supplementation to improve fracture healing: a discrete choice experiment. 8:e019685-e019685. 2018
Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial. 8:e020741-e020741. 2018
Qualitative longitudinal study of episodic disability experiences of older women living with HIV in Ontario, Canada. 8:e021507-e021507. 2018
Study protocol to assess the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units: a cluster-randomised, crossover trial (The ICU Visits Study). 8:e021193-e021193. 2018
Effectiveness of implementation interventions in improving physician adherence to guideline recommendations in heart failure: a systematic review. 8:e017765-e017765. 2018
Factor structure and convergent validity of the Derriford Appearance Scale-24 using standard scoring versus treating ‘not applicable’ responses as missing data: a Scleroderma Patient-centered Intervention Network (SPIN) cohort study. 8:e018641-e018641. 2018
Self-management interventions for adults with chronic kidney disease: a scoping review. 8:e019814-e019814. 2018
Study protocol for Vitality: a proof-of-concept randomised controlled trial of exercise training or complex mental and social activities to promote cognition in adults with chronic stroke. 8:e021490-e021490. 2018
Temporal trends in severe maternal and neonatal trauma during childbirth: a population-based observational study. 8:e020578-e020578. 2018
Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis. 8:e020991-e020991. 2018
Protocol for a prospective, school-based standardisation study of a digital social skills assessment tool for children: The Paediatric Evaluation of Emotions, Relationships, and Socialisation (PEERS) study. 8:e016633-e016633. 2018
Towards high-quality, useful practice guidelines for child and youth mental health disorders: protocol for a systematic review and consensus exercise. 8:e018053-e018053. 2018
Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences. 8:e018915-e018915. 2018
Knowledge, opinions and compliance related to the 100% smoke-free law in hospitality venues in Kampala, Uganda: cross-sectional results from theKOMPLY Project. 8:e017601-e017601. 2018
Mental disorder in children with physical conditions: a pilot study. 8:e019011-e019011. 2018
Two alternatives versus the standard Grading of Recommendations Assessment, Development and Evaluation (GRADE) summary of findings (SoF) tables to improve understanding in the presentation of systematic review results: a three-arm, randomised, controlled, non-inferiority trial. 8:e015623-e015623. 2018
Understanding frailty: a qualitative study of European healthcare policy-makers’ approaches to frailty screening and management. 8:e018653-e018653. 2018
Antiretroviral therapy for pregnant women living with HIV or hepatitis B: a systematic review and meta-analysis. 7:e019022-e019022. 2017
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy. 7:e018175-e018175. 2017
Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a protocol for a scoping review. 7:e018247-e018247. 2017
Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation. 7:e017157-e017157. 2017
Investigating the effect of sociodemographic factors on 30-day hospital readmission among medical patients in Toronto, Canada: a prospective cohort study. 7:e017956-e017956. 2017
Rationale and design of GENEiUS: a prospective observational study on the genetic and environmental determinants of body mass index evolution in Canadian undergraduate students. 7:e019365-e019365. 2017
Senior high-cost healthcare users’ resource utilization and outcomes: a protocol of a retrospective matched cohort study in Canada. 7:e018488-e018488. 2017
Values and preferences of women living with HIV who are pregnant, postpartum or considering pregnancy on choice of antiretroviral therapy during pregnancy. 7:e019023-e019023. 2017
Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance. 7:e017753-e017753. 2017
Early vasopressor use following traumatic injury: a systematic review. 7:e017559-e017559. 2017
Self-management of cardiac pain in women: an evidence map. 7:e018549-e018549. 2017
UpToDate adherence to GRADE criteria for strong recommendations: an analytical survey. 7:e018593-e018593. 2017
Association between statistical significance and time to publication among systematic reviews: a study protocol for a meta-epidemiological investigation. 7:e018856-e018856. 2017
Better early functional outcome after short stem total hip arthroplasty? A prospective blinded randomised controlled multicentre trial comparing the Collum Femoris Preserving stem with a Zweymuller straight cementless stem total hip replacement for the treatment of primary osteoarthritis of the hip. 7:e014522-e014522. 2017
Effectiveness and meaningful use of paediatric surgical safety checklists and their implementation strategies: a systematic review with narrative synthesis. 7:e016298-e016298. 2017
Implementation and impact of an online tool used in primary care to improve access to financial benefits for patients: a study protocol. 7:e015947-e015947. 2017
Mandated reporters’ experiences with reporting child maltreatment: a meta-synthesis of qualitative studies. 7:e013942-e013942. 2017
Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. 7:e018858-e018858. 2017
Correction: Medication incidents in primary care medicine: a prospective study in the Swiss Sentinel Surveillance Network (Sentinella). 7:e013658corr1-e013658corr1. 2017
Development and validation of the Fracture Risk Scale (FRS) that predicts fracture over a 1-year time period in institutionalised frail older people living in Canada: an electronic record-linked longitudinal cohort study. 7:e016477-e016477. 2017
Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis. 7:016950-016950. 2017
Presentation approaches for enhancing interpretability of patient-reported outcomes (PROs) in meta-analysis: a protocol for a systematic survey of Cochrane reviews. 7:e017138-e017138. 2017
The role of pragmatism in explaining heterogeneity in meta-analyses of randomised trials: a protocol for a cross-sectional methodological review. 7:e017887-e017887. 2017
When is a randomised controlled trial health equity relevant? Development and validation of a conceptual framework. 7:e015815-e015815. 2017
A national surveillance project on chronic kidney disease management in Canadian primary care: a study protocol. 7:e016267-e016267. 2017
Answering medical questions at the point of care: a cross-sectional study comparing rapid decisions based on PubMed and Epistemonikos searches with evidence-based recommendations developed with the GRADE approach. 7:e016113-e016113. 2017
Comparison of health-related quality of life in patients with atrial fibrillation treated with catheter ablation or antiarrhythmic drug therapy: a systematic review and meta-analysis protocol. 7:e017577-e017577. 2017
Does the person’s context influence engagement in life activities following primary knee replacement? Results from a Canadian prospective cohort study. 7:e015737-e015737. 2017
Long-term outcomes after acute myocardial infarction in countries with different socioeconomic environments: an international prospective cohort study. 7:e012715-e012715. 2017
Optic nerve sheath diameter sonography for the diagnosis of increased intracranial pressure: a systematic review and meta-analysis protocol. 7:e016194-e016194. 2017
Predictors of discharge destination from acute care in patients with traumatic brain injury. 7:e016694-e016694. 2017
Protocol for a randomised, placebo-controlled pilot study for assessing feasibility and efficacy of faecal microbiota transplantation in a paediatric ulcerative colitis population: PediFETCh trial. 7:e016698-e016698. 2017
The provision of medical assistance in dying: protocol for a scoping review. 7:e017888-e017888. 2017
Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: study protocol. 7:e017012-e017012. 2017
Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study. 7:e016216-e016216. 2017
Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial. 7:e017602-e017602. 2017
Guideline recommendations and antimicrobial resistance: the need for a change. 7:e016264-e016264. 2017
Herbal medications for surgical patients: a systematic review protocol. 7:e014290-e014290. 2017
Prevalence and antibiotic resistance ofMycoplasma genitaliumamong STI clinic attendees in Western Canada: a cross-sectional analysis. 7:e016300-e016300. 2017
Retrospective economic analysis of the transfer of services from hospitals to the community: an application to an enhanced eye care service. 7:e014089-e014089. 2017
Assessing the diagnostic accuracy of PCR-based detection ofStreptococcus pneumoniaefrom nasopharyngeal swabs collected for viral studies in Canadian adults hospitalised with community-acquired pneumonia: a Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN) study. 7:e015008-e015008. 2017
Axillary versus innominate artery cannulation for antegrade cerebral perfusion in aortic surgery: design of the Aortic Surgery Cerebral Protection Evaluation (ACE) CardioLink-3 randomised trial. 7:e014491-e014491. 2017
Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol). 7:e016847-e016847. 2017
Defining clinically important perioperative blood loss and transfusion for the Standardised Endpoints for Perioperative Medicine (StEP) collaborative: a protocol for a scoping review. 7:e016743-e016743. 2017
Effect of corticosteroid administration on neurologically deceased organ donors and transplant recipients: a systematic review and meta-analysis. 7:e014436-e014436. 2017
Evaluation of a physiatrist-directed prehabilitation intervention in frail patients with colorectal cancer: a randomised pilot study protocol. 7:e015565-e015565. 2017
Methods, applications, interpretations and challenges of interrupted time series (ITS) data: protocol for a scoping review. 7:e016018-e016018. 2017
Promoting Optimal Physical Exercise for Life (PROPEL): aerobic exercise and self-management early after stroke to increase daily physical activity—study protocol for a stepped-wedge randomised trial. 7:e015843-e015843. 2017
The Bipolar Illness Onset study: research protocol for the BIO cohort study. 7:e015462-e015462. 2017
Thinker, Soldier, Scribe: cross-sectional study of researchers' roles and author order in theAnnals of Internal Medicine. 7:e013898-e013898. 2017
A cross-sectional study measuring vanadium and chromium levels in paediatric patients with CKD. 7:e014821-e014821. 2017
Application of minimal important differences in degenerative knee disease outcomes: a systematic review and case study to informBMJRapid Recommendations. 7:e015587-e015587. 2017
Knee arthroscopy versus conservative management in patients with degenerative knee disease: a systematic review. 7:e016114-e016114. 2017
Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial). 7:e015032-e015032. 2017
Deprescribing anticholinergic and sedative medicines: protocol for a Feasibility Trial (DEFEAT-polypharmacy) in residential aged care facilities. 7:e013800-e013800. 2017
Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study. 7:e013779-e013779. 2017
Quality of reporting in abstracts of RCTs published in emergency medicine journals: a protocol for a systematic survey of the literature. 7:e014981-e014981. 2017
Atraumatic versus traumatic lumbar puncture needles: a systematic review and meta-analysis protocol. 7:e014478-e014478. 2017
Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial. 7:e015026-e015026. 2017
Impact of gender on event rates at 1 year in patients with newly diagnosed non-valvular atrial fibrillation: contemporary perspective from the GARFIELD-AF registry. 7:e014579-e014579. 2017
Improving prescribing practices with rapid diagnostic tests (RDTs): synthesis of 10 studies to explore reasons for variation in malaria RDT uptake and adherence. 7:e012973-e012973. 2017
State of reporting of primary biomedical research: a scoping review protocol. 7:e014749-e014749. 2017
Integrated collaborative care teams to enhance service delivery to youth with mental health and substance use challenges: protocol for a pragmatic randomised controlled trial. 7:e014080-e014080. 2017
Vasopressor use following traumatic injury: protocol for a systematic review. 7:e014166-e014166. 2017
Awareness and attitudes of the Lebanese population with regard to physician–pharmaceutical company interaction: a survey study. 7:e013041-e013041. 2017
Characteristics of funding of clinical trials: cross-sectional survey and proposed guidance. 7:e015997-e015997. 2017
Electronic nicotine delivery systems and/or electronic non-nicotine delivery systems for tobacco smoking cessation or reduction: a systematic review and meta-analysis. 7:e012680-e012680. 2017
External validation of the Revised Cardiac Risk Index and update of its renal variable to predict 30-day risk of major cardiac complications after non-cardiac surgery: rationale and plan for analyses of the VISION study. 7:e013510-e013510. 2017
International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). 7:e015467-e015467. 2017
Multilayered and digitally structured presentation formats of trustworthy recommendations: a combined survey and randomised trial. 7:e011569-e011569. 2017
Obstetrical brachial plexus injury (OBPI): Canada's national clinical practice guideline. 7:e014141-e014141. 2017
Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: A protocol for a suite of systematic reviews for public health and health systems. 7:e014608-e014608. 2017
Algorithm for predicting death among older adults in the home care setting: study protocol for the Risk Evaluation for Support: Predictions for Elder-life in the Community Tool (RESPECT). 6:e013666-e013666. 2016
Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol. 6:e012623-e012623. 2016
Development of a brief measure of intimate partner violence experiences: the Composite Abuse Scale (Revised)—Short Form (CAS_R-SF). 6:e012824-e012824. 2016
Process mapping evaluation of medication reconciliation in academic teaching hospitals: a critical step in quality improvement. 6:e013663-e013663. 2016
Comparative effectiveness and safety of oral anticoagulants for atrial fibrillation in real-world practice: a population-based cohort study protocol. 6:e013263-e013263. 2016
Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature. 6:e013175-e013175. 2016
Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials. 6:e013200-e013200. 2016
Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis. 6:e014390-e014390. 2016
Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies. 6:e011957-e011957. 2016
Preference-based disease-specific health-related quality of life instrument for glaucoma: a mixed methods study protocol. 6:e012732-e012732. 2016
Prevalence of papillomavirus in Brazil: a systematic review protocol. 6:e011884-e011884. 2016
Reporting quality of abstracts of trials published in top five pain journals: a protocol for a systematic survey. 6:e012319-e012319. 2016
Surgical ablation of atrial fibrillation: a protocol for a systematic review and meta-analysis of randomised controlled trials. 6:e013273-e013273. 2016
Towards the genetic basis of cerebral venous thrombosis—the BEAST Consortium: a study protocol. 6:e012351-e012351. 2016
Evaluating a community-based exercise intervention with adults living with HIV: protocol for an interrupted time series study. 6:e013618-e013618. 2016
Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies. 6:e013191-e013191. 2016
Association between progression-free survival and health-related quality of life in oncology: a systematic review protocol. 6:e012909-e012909. 2016
Exploring the experiences of substitute decision-makers with an exception to consent in a paediatric resuscitation randomised controlled trial: study protocol for a qualitative research study. 6:e012931-e012931. 2016
Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS. 6:e011148-e011148. 2016
Patient values and preferences on transcatheter or surgical aortic valve replacement therapy for aortic stenosis: a systematic review. 6:e014327-e014327. 2016
Predictors of physical functioning after total hip arthroplasty: a systematic review. 6:e010725-e010725. 2016
Strategies and impacts of patient and family engagement in collaborative mental healthcare: protocol for a systematic and realist review. 6:e012949-e012949. 2016
Comparative study analysing women's childbirth satisfaction and obstetric outcomes across two different models of maternity care. 6:e011362-e011362. 2016
False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review. 6:e011890-e011890. 2016
Impact of including or excluding both-armed zero-event studies on using standard meta-analysis methods for rare event outcome: a simulation study. 6:e010983-e010983. 2016
Effectiveness and safety of treatments used for the management of patent ductus arteriosus (PDA) in preterm infants: a protocol for a systematic review and network meta-analysis. 6:e011271-e011271. 2016
Identifying process and outcome indicators of successful transitions from child to adult mental health services: protocol for a scoping review. 6:e012376-e012376. 2016
Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial. 6:e012220-e012220. 2016
Multicountry survey of emergency and critical care medicine physicians’ fluid resuscitation practices for adult patients with early septic shock. 6:e010041-e010041. 2016
Simulation study to determine the impact of different design features on design efficiency in discrete choice experiments. 6:e011985-e011985. 2016
Understanding the role of the immune system in adolescent idiopathic scoliosis: Immunometabolic CONnections to Scoliosis (ICONS) study protocol. 6:e011812-e011812. 2016
Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness. 6:e010403-e010403. 2016
Making patient values visible in healthcare: a systematic review of tools to assess patient treatment priorities and preferences in the context of multimorbidity. 6:e010903-e010903. 2016
Measuring engagement in advance care planning: a cross-sectional multicentre feasibility study. 6:e010375-e010375. 2016
Reporting of planned statistical methods in published surgical randomised trial protocols: a protocol for a methodological systematic review. 6:e011188-e011188. 2016
Sexual counselling for patients with cardiovascular disease: protocol for a pilot study of the CHARMS sexual counselling intervention. 6:e011219-e011219. 2016
β-Blockers in sepsis: protocol for a systematic review and meta-analysis of randomised control trials. 6:e012466-e012466. 2016
Factors influencing communication and decision-making about life-sustaining technology during serious illness: a qualitative study. 6:e010451-e010451. 2016
Intrathecal hyperbaric versus isobaric bupivacaine for adult non-caesarean-section surgery: systematic review protocol. 6:e010885-e010885. 2016
Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology. 6:e011780-e011780. 2016
Treatment goal setting for complex patients: protocol for a scoping review. 6:e011869-e011869. 2016
Biologic Treatment Registry Across Canada (BioTRAC): a multicentre, prospective, observational study of patients treated with infliximab for ankylosing spondylitis. 6:e009661-e009661. 2016
CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients. 6:e011659-e011659. 2016
Cigarette smoking in a Middle Eastern country and its association with hospitalisation use: a nationwide cross-sectional study. 6:e009881-e009881. 2016
Examining the social determinants of children's developmental health: protocol for building a pan-Canadian population-based monitoring system for early childhood development. 6:e012020-e012020. 2016
Curved versusStraight Stem UncementedTotal Hip ArthroplastyOsteoarthritisMulticenter trial (CUSTOM): design of a prospective blinded randomised controlled multicentre trial. 6:e010472-e010472. 2016
Are you ready? Exploring readiness to engage in exercise among people living with HIV and multimorbidity in Toronto, Canada: a qualitative study. 6:e010029-e010029. 2016
Effect of serotonin modulating pharmacotherapies on body mass index and dysglycaemia among children and adolescents: a systematic review and network meta-analysis protocol. 6:e009998-e009998. 2016
Effectiveness of implementation strategies in improving physician adherence to guideline recommendations in heart failure: a systematic review protocol. 6:e009364-e009364. 2016
Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies. 6:e010959-e010959. 2016
Resident reflections on end-of-life education: a mixed-methods study of the 3 Wishes Project. 6:e010626-e010626. 2016
Does preoperative rehabilitation for patients planning to undergo joint replacement surgery improve outcomes? A systematic review and meta-analysis of randomised controlled trials. 6:e009857-e009857. 2016
Effect of obesity on cognition in adults with and without a mood disorder: study design and methods. 6:e009347-e009347. 2016
A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial. 6:e010156-e010156. 2016
Bias in dissemination of clinical research findings: structured OPEN framework of what, who and why, based on literature review and expert consensus. 6:e010024-e010024. 2016
Impact of point-of-care diagnostics on maternal outcomes in HIV-infected women: systematic review and meta-analysis protocol. 6:e008002-e008002. 2016
Reporting of financial and non-financial conflicts of interest by authors of systematic reviews: a methodological survey. 6:e011997-e011997. 2016
Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol. 6:e010569-e010569. 2016
Using a Delphi process to define priorities for prison health research in Canada. 6:e010125-e010125. 2016
Effect of increased water intake on plasma copeptin in patients with chronic kidney disease: results from a pilot randomised controlled trial. 5:e008634-e008634. 2015
Prediction of individual combined benefit and harm for patients with atrial fibrillation considering warfarin therapy: a study protocol. 5:e009518-e009518. 2015
Minimally important difference estimates and methods: a protocol. 5:e007953-e007953. 2015
A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees. 5:e008699-e008699. 2015
Capturing the experiences of patients across multiple complex interventions: a meta-qualitative approach. 5:e007664-e007664. 2015
Association of worker characteristics and early reimbursement for physical therapy, chiropractic and opioid prescriptions with workers’ compensation claim duration, for cases of acute low back pain: an observational cohort study. 5:e007836-e007836. 2015
Management of persistent postconcussion symptoms in youth: a randomised control trial protocol. 5:e008468-e008468. 2015
Cost-effectiveness of nurse practitioners in primary and specialised ambulatory care: systematic review. 5:e007167-e007167. 2015
Hyperbaric Oxygen in Lower Limb Trauma (HOLLT); protocol for a randomised controlled trial. 5:e008381-e008381. 2015
Rationale and methods of a multicentre randomised controlled trial of the effectiveness of a Community Health Assessment Programme with Emergency Medical Services (CHAP-EMS) implemented on residents aged 55 years and older in subsidised seniors’ housing buildings in Ontario, Canada. 5:e008110-e008110. 2015
Scoping review of physical rehabilitation interventions in long-term care: protocol for tools, models of delivery, outcomes and quality indicators. 5:e007528-e007528. 2015
Video decision aids to assist with advance care planning: a systematic review and meta-analysis. 5:e007491-e007491. 2015
What matters most for end-of-life care? Perspectives from community-based palliative care providers and administrators. 5:e007492-e007492. 2015
Are two youth-focused interventions sufficient to empower youth with chronic health conditions in their transition to adult healthcare: a mixed-methods longitudinal prospective cohort study. 5:e007553-e007553. 2015
Efficacy of temporary work modifications on disability related to musculoskeletal pain or depressive symptoms—study protocol for a controlled trial. 5:e008300-e008300. 2015
Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN (Overcome failure to Publish nEgative fiNdings) project based on an international consensus meeting. 5:e006666-e006666. 2015
Effects of electroconvulsive therapy on cognitive functioning in patients with depression: protocol for a systematic review and meta-analysis. 5:e006966-e006966. 2015
Effectiveness of knowledge translation tools addressing multiple high-burden chronic diseases affecting older adults: protocol for a systematic review alongside a realist review. 5:e007640-e007640. 2015
Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial. 5:e006263-e006263. 2015
The effect of Chinese herbal medicine Jian Ling Decoction for the treatment of essential hypertension: a systematic review. 5:e006502-e006502. 2015
Body composition and bone health in long-term survivors of acute lymphoblastic leukaemia in childhood and adolescence: the protocol for a cross-sectional cohort study. 5:e006191-e006191. 2015
Chinese herbal medicine for resistant hypertension: a systematic review. 5:e005355-e005355. 2015
Correlates of former smoking in patients with cerebrovascular disease: a cross-sectional study. 5:e005753-e005753. 2015
Interventions to combat or prevent drug counterfeiting: a systematic review. 5:e006290-e006290. 2015
Reporting missing participant data in randomised trials: systematic survey of the methodological literature and a proposed guide. 5:e008431-e008431. 2015
Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey. 5:e009368-e009368. 2015
The African, Caribbean and European (ACE) Pathways to Care study: a qualitative exploration of similarities and differences between African-origin, Caribbean-origin and European-origin groups in pathways to care for psychosis. 5:e006562-e006562. 2015
Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS. 4:e006634-e006634. 2014
Classification of osteoarthritis phenotypes by metabolomics analysis. 4:e006286-e006286. 2014
Management of chronic neuropathic pain: a protocol for a multiple treatment comparison meta-analysis of randomised controlled trials. 4:e006112-e006112. 2014
Patients’ values and preferences of the expected efficacy of hip arthroscopy for osteoarthritis: a protocol for a multinational structured interview-based study combined with a randomised survey on the optimal amount of information to elicit preferences. 4:e005536-e005536. 2014
Treatment crossovers in time-to-event non-inferiority randomised trials of radiotherapy in patients with breast cancer. 4:e006531-e006531. 2014
‘Conditional candour’ and ‘knowing me’: an interpretive description study on patient preferences for physician behaviours during end-of-life communication. 4:e005653-e005653. 2014
Interpreting trial results following use of different intention-to-treat approaches for preventing attrition bias: a meta-epidemiological study protocol. 4:e005297-e005297. 2014
Measuring disability experienced by adults living with HIV: assessing construct validity of the HIV Disability Questionnaire using confirmatory factor analysis. 4:e005456-e005456. 2014
Brazilian medicinal plants to treat upper respiratory tract and bronchial illness: systematic review and meta-analyses—study protocol. 4:e005267-e005267. 2014
Effect of tree nuts on metabolic syndrome criteria: a systematic review and meta-analysis of randomised controlled trials. 4:e004660-e004660. 2014
Extended-release nifedipine and the risk of intestinal obstruction: a population-based study. 4:e005377-e005377. 2014
Perceptions of chronically ill and healthy consumers about electronic personal health records: a comparative empirical investigation. 4:e005304-e005304. 2014
Rapid paediatric fluid resuscitation: a randomised controlled trial comparing the efficiency of two provider-endorsed manual paediatric fluid resuscitation techniques in a simulated setting. 4:e005028-e005028. 2014
Correction. 4:e005123corr1-e005123corr1. 2014
Estimating treatment effects in randomised controlled trials with non-compliance: a simulation study. 4:e005362-e005362. 2014
Outcomes after corrective surgery for congenital dextro-transposition of the great arteries using the arterial switch technique: a protocol for a scoping systematic review. 4:e005123-e005123. 2014
Recruitment feasibility to a cohort study of endocrine and metabolic health among survivors of childhood brain tumours: a report from the Canadian study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE). 4:e005295-e005295. 2014
Evidence-informed recommendations for rehabilitation with older adults living with HIV: a knowledge synthesis. 4:e004692-e004692. 2014
The clinical relevance and newsworthiness of NIHR HTA-funded research: a cohort study. 4:e004556-e004556. 2014
Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review. 4:e004971-e004971. 2014
The effect of weekly text-message communication on treatment completion among patients with latent tuberculosis infection: study protocol for a randomised controlled trial (WelTel LTBI). 4:e004362-e004362. 2014
Adherence to guidelines in the use of biological agents to treat psoriasis in Brazil. 4:e004179-e004179. 2014
Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial. 4:e004842-e004842. 2014
Systematic review of percutaneous closure versus medical therapy in patients with cryptogenic stroke and patent foramen ovale. 4:e004282-e004282. 2014
Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial. 4:e004886-e004886. 2014
Access to rheumatologists among patients with newly diagnosed rheumatoid arthritis in a Canadian universal public healthcare system. 4:e003888-e003888. 2014
Legislative, educational, policy and other interventions targeting physicians’ interaction with pharmaceutical companies: a systematic review. 4:e004880-e004880. 2014
Shorter or longer anticoagulation to prevent recurrent venous thromboembolism: systematic review and meta-analysis. 4:e005674-e005674. 2014
Mobile phone text messages for improving adherence to antiretroviral therapy (ART): an individual patient data meta-analysis of randomised trials. 3:e003950-e003950. 2013
The chronic kidney disease Water Intake Trial (WIT): results from the pilot randomised controlled trial. 3:e003666-e003666. 2013
The comparative risk of new-onset diabetes after prescription of drugs for cardiovascular risk prevention in primary care: a national cohort study. 3:e003475-e003475. 2013
A generalised model for individualising a treatment recommendation based on group-level evidence from randomised clinical trials. 3:e003143-e003143. 2013
Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions. 3:e002857-e002857. 2013
Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia. 3:e002881-e002881. 2013
Predicting and preventing postconcussive problems in paediatrics (5P) study: protocol for a prospective multicentre clinical prediction rule derivation study in children with concussion. 3:e003550-e003550. 2013
Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours. 3:e002869-e002869. 2013
Investigating community ownership of a text message programme to improve adherence to antiretroviral therapy and provider-client communication: a mixed methods research protocol. 3:e002816-e002816. 2013
The effect of weekly short message service communication on patient retention in care in the first year after HIV diagnosis: study protocol for a randomised controlled trial (WelTel Retain). 3:e003155-e003155. 2013
An observational study of the hand hygiene initiative: a comparison of preintervention and postintervention outcomes. 3:e003018-e003018. 2013
Case–control and prospective studies of dietary α-linolenic acid intake and prostate cancer risk: a meta-analysis. 3:e002280-e002280. 2013
Development and validation of a brief screening instrument for psychosocial risk associated with genetic testing: a pan-Canadian cohort study. 3:e002227-e002227. 2013
Framework of policy recommendations for implementation of evidence-based practice: a systematic scoping review. 3:e001881-e001881. 2013
Identifying geographical regions serviced by hospitals to assess laboratory-based outcomes. 3:e001921-e001921. 2013
Mobile phone text messages for improving adherence to antiretroviral therapy (ART): a protocol for an individual patient data meta-analysis of randomised trials. 3:e002954-e002954. 2013
Study protocol for a randomised controlled trial comparing the efficiency of two provider-endorsed manual paediatric fluid resuscitation techniques. 3:e002754-e002754. 2013
Sustainability of knowledge translation interventions in healthcare decision-making: protocol for a scoping review. 3:e002970-e002970. 2013
The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. 3:e002624-e002624. 2013
A retrospective cross-sectional study of risk factors and clinical spectrum of children admitted to hospital with pandemic H1N1 influenza as compared to influenza A. 2:e000310-e000310. 2012
Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY): kidney substudy analytic protocol of an international randomised controlled trial. 2:e001080-e001080. 2012
Inter-rater and test–retest reliability of quality assessments by novice student raters using the Jadad and Newcastle–Ottawa Scales. 2:e001368-e001368. 2012
Jurisdictional, socioeconomic and gender inequalities in child health and development: analysis of a national census of 5-year-olds in Australia. 2:e001075-e001075. 2012
Prophylactic antibiotic regimens in tumour surgery (PARITY): protocol for a multicentre randomised controlled study. 2:e002197-e002197. 2012
Psychometric properties of a questionnaire to assess exercise-related musculoskeletal injuries in older adults attending a community-based fitness facility. 2:e001777-e001777. 2012
The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. 2:e001474-e001474. 2012
The effectiveness of smoking cessation interventions in smokers with cerebrovascular disease: a systematic review. 2:e002022-e002022. 2012
Validity of theInternational Classification of Diseases 10th revisioncode for hospitalisation with hyponatraemia in elderly patients. 2:e001727-e001727. 2012
Validity of theInternational Classification of Diseases 10th revisioncode for hyperkalaemia in elderly patients at presentation to an emergency department and at hospital admission. 2:e002011-e002011. 2012
Validity of theInternational Classification of Diseases, Tenth Revisioncode for acute kidney injury in elderly patients at presentation to the emergency department and at hospital admission. 2:e001821-e001821. 2012
What is a disease? Perspectives of the public, health professionals and legislators. 2:e001632-e001632. 2012
A randomised controlled pilot study of standardised counselling and cost-free pharmacotherapy for smoking cessation among stroke and TIA patients. 1:e000366-e000366. 2011
The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomised controlled trial of a Housing First intervention for homeless individuals with mental illness in five Canadian cities. 1:e000323-e000323. 2011
The quality of websites addressing fibromyalgia: an assessment of quality and readability using standardised tools. 1:e000152-e000152. 2011

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