Journal article
Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial
Abstract
INTRODUCTION: Vasodilatory hypotension is common among intensive care unit (ICU) patients; vasopressors are considered standard of care. However, optimal mean arterial pressure (MAP) targets for vasopressor titration are unknown. The objective of the Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65) trial is to ascertain the effect of permissive hypotension (vasopressor titration to achieve MAP 60-65 mm Hg) versus usual …
Authors
Masse M-H; Battista M-C; Wilcox ME; Pinto R; Marinoff N; D'Aragon F; St-Arnaud C; Mayette M; Leclair M-A; Martinez HQ
Journal
BMJ Open, Vol. 10, No. 11,
Publisher
BMJ
Publication Date
November 2020
DOI
10.1136/bmjopen-2020-037947
ISSN
2044-6055