Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial Journal Articles uri icon

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  • OBJECTIVE: To assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes. DESIGN: Cross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way. SETTING: Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada. PARTICIPANTS: 325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event. MAIN OUTCOME MEASURES: CIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples. RESULTS: CIMT was significantly inversely associated with dietary pulse intake (β=-0.019, p=0.009), available carbohydrate (β=-0.004, p=0.008), glycaemic load (β=-0.001, p=0.007) and starch (β=-0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer. CONCLUSIONS: Lower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further. TRIAL REGISTRATION NUMBER: NCT01063374.


  • Chiavaroli, Laura
  • Mirrahimi, Arash
  • Ireland, Christopher
  • Mitchell, Sandra
  • Sahye-Pudaruth, Sandhya
  • Coveney, Judy
  • Olowoyeye, Omodele
  • Patel, Darshna
  • De Souza, Russell Jude
  • Augustin, Livia SA
  • Bashyam, Balachandran
  • Pichika, Sathish Chandra
  • Blanco Mejia, Sonia
  • Nishi, Stephanie K
  • Leiter, Lawrence A
  • Josse, Robert G
  • McKeown-Eyssen, Gail E
  • Moody, Alan R
  • Kendall, Cyril WC
  • Sievenpiper, John L
  • Jenkins, David JA

publication date

  • March 2017