Biological Products Concept

subject area of

• 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis  Journal Articles
• 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis  Journal Articles
• 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty  Journal Articles
• 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis  Journal Articles
• 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis–Associated Uveitis  Journal Articles
• 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non‐Systemic Polyarthritis, Sacroiliitis, and Enthesitis  Journal Articles
• 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis  Journal Articles
• A Psoriatic Patient-Based Survey on the Understanding of the Use of Vaccines While on Biologics During the COVID-19 Pandemic  Journal Articles
• A Review of Drug-Drug Interactions for Biologic Drugs Used in the Treatment of Psoriasis  Journal Articles
• A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent  Journal Articles
• A Systematic Review and Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections  Journal Articles
• A Useful Clinical Tool for Psoriasis  Journal Articles
• A brief guide to machine learning for antibiotic discovery  Journal Articles
• A case series of dual biologics therapy for severe asthma  Journal Articles
• A comparison of the effectiveness of biologic therapies for asthma  Journal Articles
• A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry  Journal Articles
• A macrophage-stimulating compound from a screen of microbial natural products  Journal Articles
• A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity  Journal Articles
• A simple bioassay for monocyte-derived hepatocyte stimulating factor: Increased synthesis of α2-macroglobulin and reduced synthesis of albumin by cultured rat hepatocytes  Journal Articles
• A systematic review of recent randomized controlled trials for palmoplantar pustulosis.  Journal Articles
• A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines  Journal Articles
• A z2 laterally-fed membrane chromatography device for fast high-resolution purification of biopharmaceuticals  Journal Articles
• Accessorizing natural products: Adding to nature's toolbox  Journal Articles
• Adjuvant Chemotherapy With or Without Biologics Including Antiangiogenics and Monoclonal Antibodies Targeting EGFR and EpCAM in Colorectal Cancer: A Systematic Review and Meta-analysis  Journal Articles
• Adverse effects of biologics: a network meta-analysis and Cochrane overview  Journal Articles
• Alveolar Macrophage/Peripheral Blood Monocyte-Derived Factors Modulate Proliferation of Primary Lines of Human Lung Fibroblasts  Journal Articles
• An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products  Journal Articles
• An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products  Journal Articles
• An ecological perspective of microbial secondary metabolism  Journal Articles
• An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α  Journal Articles
• Antibiotic Dereplication Using the Antibiotic Resistance Platform  Journal Articles
• Antibiotics: A New Hope  Journal Articles
• Applications of machine learning in microbial natural product drug discovery  Journal Articles
• Appropriateness of Biologics in the Management of Crohn’s Disease Using RAND/UCLA Appropriateness Methodology  Journal Articles
• Architectures, mechanisms and molecular evolution of natural product methyltransferases  Journal Articles
• Are there differences between young- and older-onset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort  Journal Articles
• Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance  Journal Articles
• Assembly and clustering of natural antibiotics guides target identification  Journal Articles
• Association of Patient, Prescriber, and Region With the Initiation of First Prescription of Biologic Disease-Modifying Antirheumatic Drug Among Older Patients With Rheumatoid Arthritis and Identical Health Insurance Coverage  Journal Articles
• Automated Identification of Depsipeptide Natural Products by an Informatic Search Algorithm  Journal Articles
• BSR and BHPR guideline for the treatment of axial spondyloarthritis (including ankylosing spondylitis) with biologics  Journal Articles
• Back to the future: a new ‘old’ lead for tuberculosis  Journal Articles
• Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery  Journal Articles
• Biologic survival.  Journal Articles
• Biologic therapies and bone loss in rheumatoid arthritis  Journal Articles
• Biological treatments for systemic lupus erythematosus  Journal Articles
• Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma  Journal Articles
• Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNA^UUA Molecule  Journal Articles
• Canadian Rheumatology Association Living Guidelines for the Pharmacological Management of Rheumatoid Arthritis With Disease-Modifying Antirheumatic Drugs  Journal Articles
• Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis  Journal Articles
• Canadian multidisciplinary expert consensus on the use of biologics in upper airways: A Delphi study  Journal Articles
• Certolizumab Pegol Use in the Treatment of Moderate-to-Severe Psoriasis: Real-World Data From Two Canadian Centers  Journal Articles
• Changes in Market Share of Biologic and Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs for Treatment of Rheumatoid Arthritis: Results from the Ontario Best-Practice Research Initiative Database  Journal Articles
• Checklist for the Systemic Treatment of Psoriasis Using Biologics: A Delphi Study  Journal Articles
• Chemical Analyses of Wasp-Associated Streptomyces Bacteria Reveal a Prolific Potential for Natural Products Discovery  Journal Articles
• Chemical and biosynthetic evolution of the antimycin-type depsipeptides  Journal Articles
• Chemoradiotherapy With or Without AE-941 in Stage III Non–Small Cell Lung Cancer: A Randomized Phase III Trial  Journal Articles
• Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology  Books
• Comparative Effectiveness of Biologics for Endoscopic Healing of the Ileum and Colon in Crohn's Disease  Conferences
• Comparative Efficacy and Rapidity of Action for Infliximab vs Ustekinumab in Biologic Naïve Crohn’s Disease  Journal Articles
• Comparative Efficacy for Infliximab Vs Vedolizumab in Biologic Naive Ulcerative Colitis  Journal Articles
• Comparative Efficacy of Infliximab Versus Tofacitinib for Inducing Remission in Biologic Naive Ulcerative Colitis: A Propensity Matched Study  Journal Articles
• Comparative Efficacy of Infliximab vs Ustekinumab for Maintenance of Clinical Response in Biologic Naïve Crohn’s Disease  Journal Articles
• Comparing bronchial thermoplasty with biologicals for severe asthma: Systematic review and network meta-analysis  Journal Articles
• Comparison of the acute phase response of cultured Morris hepatoma 7777 cells and of rat hepatocytes.  Journal Articles
• Complete Response as an Intermediate End Point in Patients Receiving Salvage Systemic Therapy for Urothelial Carcinoma  Journal Articles
• Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions  Journal Articles
• Controversies Around Measuring Drug Toxicity: US Food and Drug Administration and Gastrointestinal Perspectives  Journal Articles
• Controversies in Allergy: Aspirin Desensitization or Biologics for Aspirin-Exacerbated Respiratory Disease—How to Choose  Journal Articles
• Cost-effectiveness analysis of secukinumab for the treatment of active psoriatic arthritis: a Canadian perspective  Journal Articles
• Current use of biologicals in thrombosis and haemostasis  Journal Articles
• Cytokines and other mediators in rheumatoid arthritis  Journal Articles
• Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology  Journal Articles
• DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products  Journal Articles
• Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery  Journal Articles
• Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice  Journal Articles
• Development of isoporous microslit silicon nitride membranes for sterile filtration applications  Journal Articles
• Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function  Journal Articles
• Does the Addition of Biologic Agents to Chemotherapy in Patients with Unresectable Colorectal Cancer Metastases Result in a Higher Proportion of Patients Undergoing Resection? A Systematic Review and Meta-analysis  Journal Articles
• Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis  Journal Articles
• Early Change in Epithelial Neutrophilic Infiltrate Predicts Long-Term Response to Biologics in Ulcerative Colitis  Journal Articles
• Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results  Journal Articles
• Effect of anti‐IL‐5 biologics on weight and body mass index  Journal Articles
• Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn’s Disease: Systematic Review and Meta-Analysis  Journal Articles
• Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma  Journal Articles
• Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma  Journal Articles
• Efficacy and safety of treatment with dupilumab for severe asthma: A systematic review of the EAACI guidelines—Recommendations on the use of biologicals in severe asthma  Journal Articles
• Efficacy of Biologics in Patients with Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis  Journal Articles
• Emerging evolutionary paradigms in antibiotic discovery  Journal Articles
• Enantioselective Organocatalytic Michael/Aldol Sequence: Anticancer Natural Product (+)‐trans‐Dihydrolycoricidine  Journal Articles
• Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals  Journal Articles
• Eosinophils and therapeutic responses to steroids and biologics in COPD: a complex relationship  Journal Articles
• Epidermal Interleukin-1 is Increased in Cutaneous T-Cell Lymphoma  Journal Articles
• Estimation of Pulmonary Deposition of Aerosol Using Gamma Scintigraphy  Journal Articles
• Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers  Journal Articles
• Evidence-Based Guideline: ACR made 10 strong treatment recommendations for RA, but high-quality evidence was sparse  Journal Articles
• Evolving medicinal chemistry strategies in antibiotic discovery  Journal Articles
• Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites  Journal Articles
• Exploration of Nonribosomal Peptide Families with an Automated Informatic Search Algorithm  Journal Articles
• Exploring Perceptions of Biologic Therapies: A Qualitative Study Among Canadians Living with Severe Asthma  Journal Articles
• Exploring the outcomes of research engagement using the observation method in an online setting  Journal Articles
• Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device  Journal Articles
• Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)  Journal Articles
• Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining  Journal Articles
• Glycopeptide antibiotic discovery in the genomic era  Chapters
• Heterogeneity in Patient Characteristics and Differences in Treatment Across 4 Canadian Rheumatoid Arthritis Cohorts  Journal Articles
• Heterologous Expression and Structural Characterisation of a Pyrazinone Natural Product Assembly Line  Journal Articles
• Heterologous expression-facilitated natural products’ discovery in actinomycetes  Journal Articles
• High functional diversity among Nitrospira populations that dominate rotating biological contactor microbial communities in a municipal wastewater treatment plant  Journal Articles
• Histological Remission Placebo Rates in Ulcerative Colitis Trials: A Systematic Review and Meta-analysis  Journal Articles
• Impact of using concomitant conventional DMARDs on adherence to biologic DMARD treatment in rheumatoid arthritis: Multi-centre, population-based cohort study.  Journal Articles
• Improvement in work productivity among psoriatic arthritis patients treated with biologic or targeted synthetic drugs: a systematic literature review and meta-analysis  Journal Articles
• Incidence and prognosis of COVID‐19 in psoriasis patients on biologic therapy: a multicentre retrospective cohort study  Journal Articles
• Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors  Journal Articles
• Inducing Global Expression of Actinobacterial Biosynthetic Gene Clusters  Journal Articles
• Informatic search strategies to discover analogues and variants of natural product archetypes  Journal Articles
• Inspired by nature: investigating tetrataenite for permanent magnet applications  Journal Articles
• Integrating Evidence to Guide Use of Biologics and Small Molecules for Inflammatory Bowel Diseases  Journal Articles
• Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory  Journal Articles
• Long-term safety of biologics in dermatology  Journal Articles
• MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product  Journal Articles
• Management of Juvenile Idiopathic Arthritis 2015: A Position Statement from the Pediatric Committee of the Canadian Rheumatology Association  Journal Articles
• Management of adult generalized pustular psoriasis using biologics: A systematic review  Journal Articles
• Management of pediatric generalized pustular psoriasis using biologics: An evidence-based review  Journal Articles
• Modelling the benefits of an optimised treatment strategy for 5-ASA in mild-to-moderate ulcerative colitis  Journal Articles
• Monitoring eosinophils to guide therapy with biologics in asthma: does the compartment matter?  Journal Articles
• Much ado about Biologicals: Highlights of the Master Class on Biologicals, Prague, 2018  Journal Articles
• Natural health product use in Canada: analysis of the National Population Health Survey.  Journal Articles
• Natural products for the treatment of neurodegenerative diseases  Journal Articles
• Natural products in diabetes research: quantitative literature analysis.  Journal Articles
• Nebulisation of surfactants in an animal model of neonatal respiratory distress  Journal Articles
• New paradigm in asthma management: Switching between biologics!  Journal Articles
• No improvement in disclosure of natural health product use to primary care medical doctors in the last 15 years: A survey of naturopathic patients  Journal Articles
• Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein‐Associated Phospholipase Inhibitors  Journal Articles
• ONS Guidelines™ for Cancer Treatment–Related Hot Flashes in Women With Breast Cancer and Men With Prostate Cancer  Journal Articles
• Occurrence of Serious Infection in Patients with Rheumatoid Arthritis Treated with Biologics and Denosumab Observed in a Clinical Setting  Conferences
• Opportunities for natural products in 21^st century antibiotic discovery  Journal Articles
• Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study  Journal Articles
• PRISM 3: expanded prediction of natural product chemical structures from microbial genomes  Journal Articles
• Patients With Crohn's Disease and Permanent Ileostomy Are Universally Excluded From Clinical Trials: A Systematic Review  Journal Articles
• Perspective: Synthetic biology revives antibiotics  Journal Articles
• Plasma-derived biological medicines used to promote haemostasis  Journal Articles
• Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors  Journal Articles
• Poractant alfa versus bovine lipid extract surfactant for infants 24+0 to 31+6 weeks gestational age: A randomized controlled trial  Journal Articles
• Poractant alfa versus bovine lipid extract surfactant: prospective comparative effectiveness study  Journal Articles
• Potential Interactions Between Pharmaceuticals and Natural Health Products in Canada  Journal Articles
• Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort  Journal Articles
• Proactive therapeutic drug monitoring of biologic drugs in adult patients with inflammatory bowel disease, inflammatory arthritis, or psoriasis: a clinical practice guideline.  Journal Articles
• Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7  Journal Articles
• Pyonitrins A–D: Chimeric Natural Products Produced by Pseudomonas protegens  Journal Articles
• Real-World Persistence of Ustekinumab in the Treatment of Inflammatory Bowel Disease  Journal Articles
• Reply to Yilmaz: Selection of Biologics for Type 2–High Asthma  Journal Articles
• Resolution of dominant patient‐reported outcome at end of induction predicts clinical and endoscopic remission in Crohn’s disease  Journal Articles
• Response of sputum periostin to anti‐T2 biologics treatment in severe asthma  Journal Articles
• Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic review and pooled analysis  Journal Articles
• Review and Practical Guidance on Managing Fungal Infections in Patients With Psoriasis Receiving Anti-IL-17 Therapies  Journal Articles
• Review of Systemic Treatment Options for Adult Atopic Dermatitis  Journal Articles
• Role of Biologics in Asthma  Journal Articles
• Role of Epidermal Cell Thymocyte-Activating Factor in the Proliferation and Differentiation of Murine B Cells  Journal Articles
• Saffron Pre-Treatment Promotes Reduction in Tissue Inflammatory Profiles and Alters Microbiome Composition in Experimental Colitis Mice  Journal Articles
• Self-reported use of natural health products: A cross-sectional telephone survey in older Ontarians  Journal Articles
• Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60  Journal Articles
• Something old, something new: revisiting natural products in antibiotic drug discovery  Journal Articles
• Speed of clinical improvement in the real‐world setting from patient‐reported Psoriasis Symptoms and Signs Diary: Secondary outcomes from the Psoriasis Study of Health Outcomes through 12 weeks  Journal Articles
• Statistical reanalysis of natural products reveals increasing chemical diversity  Journal Articles
• Strategies for target identification of antimicrobial natural products  Journal Articles
• Sulfate was a trace constituent of Archean seawater  Journal Articles
• Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation  Journal Articles
• Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics  Journal Articles
• Targeting the Resistance of Pancreatic Cancer Cells to Nutrient Deprivation: Anti-Austerity Compounds  Journal Articles
• The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents  Journal Articles
• The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel drugs  Journal Articles
• The Cost Effectiveness of Axicabtagene Ciloleucel Versus Best Supportive Care in the Treatment of Adult Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL) After Two or More Lines of Systemic Therapy in Canada  Journal Articles
• The Effects of Red Yeast Rice Dietary Supplement on Blood Pressure, Lipid Profile and C-reactive Protein in Hypertension: A Systematic Review  Journal Articles
• The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis  Journal Articles
• The Joint Task Force on Practice Parameters GRADE guidelines for the medical management of chronic rhinosinusitis with nasal polyposis  Journal Articles
• The Real-World Effectiveness and Safety of Ustekinumab in the Treatment of Crohn's Disease: Results From the SUCCESS Consortium  Journal Articles
• The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines  Journal Articles
• The antimicrobial potential of Streptomyces from insect microbiomes  Journal Articles
• The development of a DNA microarray-based assay for the characterization of commercially formulated microbial products  Journal Articles
• The effect of antimalarials on the safety and persistence of treatment with biologic agents or Janus kinase inhibitors in rheumatoid arthritis  Journal Articles
• The interleukin-13 paradox in asthma: effective biology, ineffective biologicals  Journal Articles
• The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort  Journal Articles
• Thiopeptides: antibiotics with unique chemical structures and diverse biological activities  Journal Articles
• Ulcerative colitis  Journal Articles
• Ulcerative colitis.  Journal Articles
• Ultrahigh‐speed, ultrahigh‐resolution preparative separation of protein biopharmaceuticals using membrane chromatography  Journal Articles
• Under-Reporting of COVID-19 Infections in Psoriasis Patients on Biologics  Journal Articles
• Unlocking the potential of natural products in drug discovery  Journal Articles
• Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial  Journal Articles
• Vedolizumab and Adalimumab in Biologic-Naïve Ulcerative Colitis: Comparison of Patient-Level Clinical Trial Data and VARSITY for Week 6 Clinical Remission  Journal Articles
• WHO Expert Committee on Biological Standardization.  Conferences
• What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors  Journal Articles
• Who Expert Committee on Biological Standardization.  Books
• β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents  Journal Articles