Journal article
Vedolizumab and Adalimumab in Biologic-Naïve Ulcerative Colitis: Comparison of Patient-Level Clinical Trial Data and VARSITY for Week 6 Clinical Remission
Abstract
BackgroundIndirect treatment comparisons using patient-level data are increasing in popularity within inflammatory bowel disease research. We compared the efficacy of adalimumab and vedolizumab for biologic-naïve moderate–severe ulcerative colitis (UC) using indirect comparisons of phase 3 clinical trials and compared the results to the RCT VARSITY.DesignPooled analysis of patient-level data from 518 biologic-naïve patients with UC was …
Authors
Narula N; Wong ECL; Dulai PS; Marshall JK; Jairath V; Reinisch W
Journal
Digestive Diseases and Sciences, Vol. 68, No. 6, pp. 2658–2666
Publisher
Springer Nature
Publication Date
June 2023
DOI
10.1007/s10620-023-07825-4
ISSN
0163-2116