Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining Academic Article uri icon

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  • Significance Natural products and their derivatives are essential to the treatment of many diseases. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a class of natural products noted for their bioactivities. Genome sequencing has revealed that most natural products remain undiscovered, but the complexity and diversity of RiPPs has challenged the systematic identification of these molecules from genomic data. Here, we present an algorithm for RiPP structure prediction from prokaryotic genomes and systematically investigate the chemical space occupied by genetically encoded RiPPs. We reveal widespread biosynthesis of RiPPs by prokaryotes, identify candidates for targeted discovery, and isolate a RiPP from a rare family.


  • Skinnider, Michael A
  • Johnston, Chad W
  • Edgar, Robyn E
  • Dejong, Chris A
  • Merwin, Nishanth J
  • Rees, Philip N
  • Magarvey, Nathan

publication date

  • October 18, 2016