Protein Kinase Inhibitors
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2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty Academic Article
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4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques Academic Article
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8-isoprostaglandin E2 activates Ca2+-dependent K+ current via cyclic AMP signaling pathway in murine renal artery Academic Article
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BCR–ABL1 transcript doubling time as a predictor for treatment‐free remission failure after imatinib discontinuation in chronic myeloid leukaemia in chronic phase Academic Article
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A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours Academic Article
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A Phase I Study of the combination of oxaliplatin/docetaxel and vandetanib for the treatment of advanced gastroesophageal cancer Academic Article
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A Phase I study of cyclin-dependent kinase inhibitor, AT7519, in patients with advanced cancer: NCIC Clinical Trials Group IND 177 Academic Article
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A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome Academic Article
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A lentiviral vector‐based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma Academic Article
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A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication Academic Article
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A phase II study of AT9283, an aurora kinase inhibitor, in patients with relapsed or refractory multiple myeloma: NCIC clinical trials group IND.191 Academic Article
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A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer Academic Article
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A phase II trial of ZD1839 (Iressa™) 750 mg per day, an oral epidermal growth factor receptor-tyrosine kinase inhibitor, in patients with metastatic colorectal cancer Academic Article
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A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group Academic Article
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A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium Academic Article
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A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium Academic Article
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A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors Academic Article
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A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study Academic Article
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A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naïve castration-resistant prostate cancer Academic Article
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A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients Academic Article
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ALK inhibitor-induced bradycardia: A systematic-review and meta-analysis Academic Article
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Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis Academic Article
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Activity of cabozantinib after immune checkpoint blockade in metastatic clear-cell renal cell carcinoma Academic Article
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Akt isoform specific effects in ovarian cancer progression Academic Article
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Allosteric linkers in cAMP signalling Academic Article
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An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma Academic Article
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An international expanded-access programme of everolimus: Addressing safety and efficacy in patients with metastatic renal cell carcinoma who progress after initial vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy Academic Article
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Assessment of Alectinib vs Ceritinib in ALK-Positive Non–Small Cell Lung Cancer in Phase 2 Trials and in Real-world Data Academic Article
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Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1 Academic Article
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Biology and patterns of response to EGFR-inhibition in squamous cell cancers of the lung and head & neck Academic Article
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Bruton’s tyrosine kinase Inhibitors and Cardiotoxicity: More Than Just Atrial Fibrillation Academic Article
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CMV and BKPyV infections in renal transplant recipients receiving an mTOR inhibitor–based regimen versus a cni-based regimen: a systematic review and meta-analysis of randomized, controlled trials Academic Article
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Cabozantinib real‐world effectiveness in the first‐through fourth‐line settings for the treatment of metastatic renal cell carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium Academic Article
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Canadian Consensus Recommendations on the Management of MET-Altered NSCLC Academic Article
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Canadian Perspectives: Update on Inhibition of ALK-Positive Tumours in Advanced Non-Small-Cell Lung Cancer Academic Article
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Canadian chronic myeloid leukemia outcomes post-transplant in the tyrosine kinase inhibitor era Academic Article
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Cardiovascular Safety Of Nintedanib In Subgroups By Cardiovascular Risk At Baseline In The Tomorrow And Inpulsis Trials Conference Paper
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Cardiovascular events in chronic myeloid leukemia clinical trials. Is it time to reassess and report the events according to cardiology guidelines? Academic Article
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Cardiovascular toxicities of BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: preventive strategies and cardiovascular surveillance Academic Article
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Challenges to Implementation of an Epidermal Growth Factor Receptor Testing Strategy for Non–Small-Cell Lung Cancer in a Publicly Funded Health Care System Academic Article
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Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials Academic Article
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Characterizing Frailty In Myeloproliferative Neoplasms: results from the ORCHID study Academic Article
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Checkpoint inhibitor-associated autoimmunity Academic Article
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Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A Academic Article
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Clinical impact of mutation fraction in epidermal growth factor receptor mutation positive NSCLC patients Academic Article
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Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase Academic Article
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Controlling angiogenesis in breast cancer: A systematic review of anti-angiogenic trials Academic Article
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Crizotinib Inhibition of ROS1-Positive Tumours in Advanced Non-Small-Cell Lung Cancer: A Canadian Perspective Academic Article
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Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors Academic Article
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Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial Academic Article
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Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib Academic Article
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Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis Academic Article
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Determination of soluble CAMP-dependent protein kinase activity in guinea-pig tracheal smooth muscle Academic Article
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Diagnosis and Management of Cardiovascular Effects of Bruton's Tyrosine Kinase Inhibitors Academic Article
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EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP) Academic Article
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Effect of nintedanib in patients with progressive pulmonary fibrosis associated with rheumatoid arthritis: data from the INBUILD trial Academic Article
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Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue Academic Article
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Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis Academic Article
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Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline Academic Article
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Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome Academic Article
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Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol Academic Article
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Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy Academic Article
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Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice Academic Article
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Gender andBCR-ABLtranscript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia Academic Article
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Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1–Induced Pulmonary Fibrosis Academic Article
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Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity Academic Article
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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Academic Article
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Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response Academic Article
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Hypoxia-Induced Lactate Dehydrogenase Expression and Tumor Angiogenesis Academic Article
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Identification of early breast cancer patient cohorts who may benefit from lapatinib therapy Academic Article
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Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors Academic Article
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Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors Academic Article
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Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial Academic Article
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Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors Academic Article
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Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin Academic Article
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Intedanib, a triple kinase inhibitor of VEGFR, FGFR and PDGFR for the treatment of cancer and idiopathic pulmonary fibrosis. Academic Article
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Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors Academic Article
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Kinase inhibitors for cancer alter metabolism, blood glucose, and insulin Academic Article
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Kinase inhibitors modulate huntingtin cell localization and toxicity Academic Article
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Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia Academic Article
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Lorlatinib Effectiveness and Quality-of-Life in Patients with ALK-Positive NSCLC Who Had Failed Second-Generation ALK Inhibitors: Canadian Real-World Experience Academic Article
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Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells Academic Article
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Major arterial events in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a meta-analysis Academic Article
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Management of HER2-positive breast cancer in Asia: consensus statement from the Asian Oncology Summit 2009 Academic Article
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Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum. Conference Paper
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Mechanisms of Cardiovascular Toxicity of BCR-ABL1 Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia Academic Article
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Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators Academic Article
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Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition Academic Article
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Nintedanib and Sildenafil in Patients with Idiopathic Pulmonary Fibrosis and Right Heart Dysfunction. A Prespecified Subgroup Analysis of a Double-Blind Randomized Clinical Trial (INSTAGE) Academic Article
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Nintedanib and immunomodulatory therapies in progressive fibrosing interstitial lung diseases Academic Article
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Nintedanib in Progressive Fibrosing Interstitial Lung Diseases Academic Article
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Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial Academic Article
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Nintedanib in progressive interstitial lung diseases: data from the whole INBUILD trial Academic Article
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Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance Academic Article
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Optimal duration of imatinib treatment/deep molecular response for treatment‐free remission after imatinib discontinuation from a Canadian tyrosine kinase inhibitor discontinuation trial Academic Article
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Optimizing Survival and the Changing Landscape of Targeted Therapy for Intermediate and Advanced Hepatocellular Carcinoma: A Systematic Review Academic Article
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Osimertinib in UntreatedEGFR-Mutated Advanced Non–Small-Cell Lung Cancer Academic Article
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Outcomes in Black and White Patients With Metastatic Renal Cell Carcinoma Treated With First-Line Tyrosine Kinase Inhibitors: Insights From Two Large Cohorts Academic Article
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Outcomes of children with chronic myeloid leukemia: A population‐based cohort study Academic Article
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Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC Academic Article
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PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma Academic Article
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PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells Academic Article
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PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer Academic Article
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Palbociclib in hormone receptor positive advanced breast cancer: A cost-utility analysis Academic Article
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Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K/AKT and COX pathways Academic Article
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Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children Academic Article
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Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors Academic Article
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Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies Academic Article
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Phase II Trial of Sorafenib in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Nasopharyngeal Carcinoma Conference Paper
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Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199) Academic Article
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Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis Academic Article
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Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice Academic Article
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Pooled Analysis of the Prognostic and Predictive Value of KRAS Mutation Status and Mutation Subtype in Patients with Non–Small Cell Lung Cancer Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Academic Article
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Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives Academic Article
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Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases Academic Article
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Predicting response to EGFR-tyrosine kinase inhibitors among diverse ancestries: Just way too polymorphic Academic Article
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Predictive and Pharmacodynamic Biomarker Studies in Tumor and Skin Tissue Samples of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Treated With Erlotinib Academic Article
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Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor Academic Article
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Progressive fibrosing interstitial lung disease: treatable traits and therapeutic strategies Academic Article
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Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3α/β regulate foam cell formation Academic Article
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Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma Academic Article
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Quizartinib for the treatment of acute myeloid leukemia Academic Article
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RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice Academic Article
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Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520 Academic Article
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Randomized, Placebo-Controlled, Phase III Study of First-Line Oxaliplatin-Based Chemotherapy Plus PTK787/ZK 222584, an Oral Vascular Endothelial Growth Factor Receptor Inhibitor, in Patients With Metastatic Colorectal Adenocarcinoma Academic Article
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Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo Academic Article
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Real-time fluorogenic kinase assay using protein as substrate Academic Article
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Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M Academic Article
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Response to ‘Adverse cardiac outcomes in patients with chronic myeloid leukaemia treated with tyrosine kinase inhibitors’ Academic Article
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Reversible Cabozantinib-Induced Cardiomyopathy Academic Article
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Role of α-Helical Coiled-coil Interactions in Receptor Dimerization, Signaling, and Adaptation during Bacterial Chemotaxis Academic Article
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Safety and efficacy of lorlatinib against ALK-driven refractory or relapsed neuroblastoma Academic Article
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Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America Academic Article
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Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Sorafenib: A Review of Four Phase I Trials in Patients with Advanced Refractory Solid Tumors Academic Article
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Severe Bronchorrhea in a Patient with Bronchioloalveolar Carcinoma Academic Article
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Simultaneous Inhibition Assay for Human and Microbial Kinases via MALDI-MS/MS Academic Article
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Sirolimus and mTORC1: centre stage in the story of what makes muscles bigger? Academic Article
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Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise Academic Article
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Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation (SORMAIN) Academic Article
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Stereotactic Radiotherapy for Oligoprogression in Metastatic Renal Cell Cancer Patients Receiving Tyrosine Kinase Inhibitor Therapy: A Phase 2 Prospective Multicenter Study Conference Paper
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Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance Academic Article
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Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation Academic Article
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Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results Academic Article
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Synthesis and Biological Activity of a Focused Library of Mitogen-activated Protein Kinase Phosphatase Inhibitors Academic Article
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Systemic Therapy for Previously Untreated Advanced BRAF-Mutated Melanoma Academic Article
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Targeted therapy for metastatic renal cell carcinoma Academic Article
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Targeting the epidermal growth factor receptor in non-small-cell lung cancer: Who, which, when, and how? Academic Article
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The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents Academic Article
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The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group Academic Article
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The effect of mTOR inhibition on obstructive hydrocephalus in patients with tuberous sclerosis complex (TSC) related subependymal giant cell astrocytoma (SEGA) Academic Article
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The impact of ruxolitinib on thrombosis in patients with polycythemia vera and myelofibrosis Academic Article
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The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I Academic Article
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The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis Academic Article
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Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia Academic Article
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Therapeutic effects of nintedanib are not influenced by emphysema in the INPULSIS trials Academic Article
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Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline Academic Article
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Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update Academic Article
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Treatment Outcomes in Chronic Myeloid Leukemia: Does One Size Fit All? Academic Article
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Treatment of idiopathic pulmonary fibrosis with Nintedanib: an update Academic Article
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Tyrosine Kinase Inhibitor Therapy in Unresectable Locally Advanced NSCLC: Keep Holding Our Breaths or Time to Take a Breather? Academic Article
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Tyrosine kinase inhibitors and tumor lysis syndrome in hematologic malignancies: A systemic review Academic Article
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Tyrosine kinase inhibitors in chronic myeloid leukaemia and emergent cardiovascular disease Academic Article
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Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia Academic Article
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Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of Bone Academic Article
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Vemurafenib-induced radiation recall dermatitis: case report and review of the literature. - PubMed - NCBI Article
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β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis Academic Article