Journal article
Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520
Abstract
BackgroundBI 853520 is a potent inhibitor of focal adhesion kinase and is currently under clinical development for the treatment of non-hematological malignancies.ObjectiveThe objective of this study was to evaluate the effect of food and liquid dispersion on the pharmacokinetics of BI 853520 in two open-label, crossover substudies.Patients and MethodsSixteen patients with advanced solid tumors were enrolled in each substudy. The order of …
Authors
Verheijen RB; van der Biessen DAJ; Hotte SJ; Siu LL; Spreafico A; de Jonge MJA; Pronk LC; De Vos FYFL; Schnell D; Hirte HW
Journal
Targeted Oncology, Vol. 14, No. 1, pp. 67–74
Publisher
Springer Nature
Publication Date
February 2019
DOI
10.1007/s11523-018-00618-0
ISSN
1776-2596