Journal article
Nintedanib and Sildenafil in Patients with Idiopathic Pulmonary Fibrosis and Right Heart Dysfunction. A Prespecified Subgroup Analysis of a Double-Blind Randomized Clinical Trial (INSTAGE)
Abstract
Rationale: In the INSTAGE trial in patients with idiopathic pulmonary fibrosis (IPF) and severely impaired gas exchange, nintedanib plus sildenafil was associated with numerical benefits on St. George's Respiratory Questionnaire (SGRQ) total score, brain natriuretic peptide (BNP), and FVC decline versus nintedanib alone. Exploratory analyses of the STEP-IPF (Sildenafil Trial of Exercise Performance in IPF) trial suggested that sildenafil may …
Authors
Behr J; Kolb M; Song JW; Luppi F; Schinzel B; Stowasser S; Quaresma M; Martinez FJ
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 200, No. 12, pp. 1505–1512
Publisher
American Thoracic Society
Publication Date
December 15, 2019
DOI
10.1164/rccm.201903-0488oc
ISSN
1073-449X