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Mechanisms of Cardiovascular Toxicity of BCR-ABL1...
Journal article

Mechanisms of Cardiovascular Toxicity of BCR-ABL1 Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia

Abstract

Purpose of ReviewOral tyrosine kinase inhibitors have revolutionized the treatment of chronic myelogenous leukemia, with many patients achieving major clinical and molecular responses without complications. While typically well-tolerated, clinical experience with tyrosine kinase inhibitors (particularly those of the second and third generations) has highlighted unanticipated associations with serious non-cancer adverse effects on various …

Authors

Gustafson D; Fish JE; Lipton JH; Aghel N

Journal

Current Hematologic Malignancy Reports, Vol. 15, No. 1, pp. 20–30

Publisher

Springer Nature

Publication Date

February 2020

DOI

10.1007/s11899-020-00560-x

ISSN

1558-8211