Journal article
Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity
Abstract
Increasing body of evidence indicates that neuron-neuroglia interaction may play a key role in determining the progression of neurodegenerative diseases including Parkinson’s disease (PD), a chronic pathological condition characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra. We have previously reported that guanosine (GUO) antagonizes MPP+-induced cytotoxicity in neuroblastoma cells and exerts neuroprotective …
Authors
Giuliani P; Ballerini P; Buccella S; Ciccarelli R; Rathbone MP; Romano S; D’Alimonte I; Caciagli F; Di Iorio P; Pokorski M
Journal
Advances in Experimental Medicine and Biology, Vol. 837, , pp. 23–33
Publisher
Springer Nature
Publication Date
2014
DOI
10.1007/5584_2014_73
ISSN
0065-2598
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisAstrocytesBiological TransportButadienesCell Line, TumorChromonesDNA FragmentationDrug Evaluation, PreclinicalGliomaGuanosineIn Vitro TechniquesMAP Kinase Signaling SystemMorpholinesNeuroprotective AgentsNeurotoxinsNitrilesNucleoside Transport ProteinsOxidopaminePhosphatidylinositol 3-KinasesProtein Kinase InhibitorsProto-Oncogene Proteins c-aktRatsSignal Transduction