High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Academic Article uri icon

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abstract

  • Key Points Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.

authors

  • Oppermann, Sina
  • Ylanko, Jarkko
  • Shi, Yonghong
  • Hariharan, Santosh
  • Oakes, Christopher C
  • Brauer, Patrick M
  • Zúñiga-Pflücker, Juan C
  • Leber, Brian
  • Spaner, David E
  • Andrews, David W

publication date

  • August 18, 2016

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