selected scholarly activity
-
books
-
chapters
- Nutrition and Pregnancy Outcomes 2024
- Early Life Adversity and Female Reproductive Outcomes How Growth, Diet, and Nutrition Impact Reproductive Function and Accelerated Reproductive Ageing. 111-120. 2023
- Early Life Adversity and Female Reproductive Outcomes. 111-120. 2022
- Hormones in Pregnancy and the Developmental Origins of Health and Disease. 189-198. 2022
- Nutrition and Pregnancy Outcomes. 569-581. 2018
- The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations. Molecular and Integrative Toxicology. 245-267. 2016
- MULTI-DIMENTIONAL CONNECTIONS: THE LIGGINS EDUCATION NETWORK FOR SCIENCE: Developing Partnerships to Enhance Science Education. 161-173. 2012
- Multi-Dimentional Connections. 161-173. 2012
- 7 Feast or Famine: In the fast lane to puberty. 59-68. 2011
- Development of the Fetal Hypothalamic-Pituitary-Adrenal-Placental Axis: Implications for Postnatal Health. 89-99. 2009
- Developmental Origins of Reproductive Health. 113-122. 2009
- The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease. 191-205. 2006
- Programming the fetal pancreatic axes. 85-95. 2005
- Fetal HPA activation, preterm birth and postnatal programming. 114-141. 2005
-
conferences
- DNA Methylation Programming and Environmental Influences During Rat Gametogenesis. Environmental and Molecular Mutagenesis. 87-87. 2022
- TH42. APPLICATION OF REFERENCE-BASED CELL TYPE ESTIMATION IN PLACENTAL TISSUE AND COMPARISON WITH A REFERENCE-FREE APPROACH FOR DNA METHYLATION STUDIES. European Neuropsychopharmacology. e216-e217. 2021
- EPIPLACENTAL ARTERIES IN PLACENTA PERCRETA PRESENT VON WILLEBRAND FACTOR-NEGATIVE ENDOTHELIUM. Placenta. E39-E40. 2021
- FROM CLINIC TO BENCH - RECOMMENDATION FOR HUMAN PLACENTA COLLECTION IN CLINICAL STUDIES. Placenta. E74-E75. 2021
- Investigating the normalization and normative views of gestational weight gain: Balancing recommendations with the promotion and support of healthy pregnancy diets. American Journal of Human Biology. e23604. 2021
- Paternal Obesity is Associated with Endoplasmic Reticulum Stress-Induced Placental Hypoxia and Altered Vascularization Without Changes in Maternal Glucose Tolerance in Pregnancy. Placenta. e9-e9. 2021
- KDMIA mediates transgenerational metabolic disturbances in a sex-specific manner and is linked to diet-induced altered sperm chromatin signatures. Human Reproduction. 122-122. 2020
- The normalization of the healthy pregnancy through national pregnancy healthy eating and gestational weight guidelines.. American Journal of Human Biology. 2020
- Influence of high fat diet on the enteric nervous system during pregnancy. Neurogastroenterology and Motility. 2019
- Food insecurity and its role in the Developmental Origins of Health and Disease (DOHaD): The Mothers to Babies (M2B) study in Hamilton, Ontario, Canada. American Journal of Human Biology. 2019
- Media interpretations of "Palaeo-diets" for pregnant women, babies, and toddlers: Relationships to anthropological evidence and public health guidelines. American Journal of Physical Anthropology. 162-162. 2019
- Risk of complication diagnoses is associated with higher levels of food insecurity during pregnancy: New evidence and an evolutionary perspective from the Mothers to Babies nutrition study in Hamilton, Canada. American Journal of Human Biology. 2019
- Maternal Obesity, the Gut Microbiome, and Long-Term Disease Risk. Annals of Nutrition and Metabolism. 102-102. 2016
- Antenatal glucocorticoid treatment – Validation of internal reference genes in the human placenta. Placenta. A18-A18. 2015
- G.O.2. Neuromuscular Disorders. 792-793. 2014
- Long-Term Sex-Specific Effects of a Single Course of Antenatal Betamethasone Treatment on the Placental Cortisol Barrier.. Reproductive Sciences. 162A-162A. 2014
- Perinatal Exposure to a Selective Serotonin Reuptake Inhibitor (SSRI) Induces Changes in Reproductive Function in Female Rat Offspring.. Reproductive Sciences. 271A-271A. 2014
- The Role of the Placenta in Fetal Programming. Research and Perspectives in Endocrine Interactions. 57-69. 2014
- Early maternal dexamethasone administration and the effect on ovine placental lactogen. Placenta. A92-A92. 2013
- Sex-specific differences in the sheep placenta. Placenta. A91-A92. 2013
- Early Maternal Dexamethasone Treatment and the Choice of Reference Genes for Normalization of RT-PCR in Fetal Sheep Liver. Reproductive Sciences. 211A-211A. 2013
- Negative Effects of Antenatal Betamethasone Treatment in Twin Pregnancies.. Reproductive Sciences. 275A-275A. 2013
- EARLY DEXAMETHASONE TREATMENT RESULTS IN STRUCTURAL ABNORMALITIES IN SHEEP PLACENTOMES. Placenta. A98-A98. 2012
- FETAL GROWTH RESTRICTING EFFECTS OF A SINGLE COURSE OF ANTENATAL BETAMETHASONE IN WOMEN: ROLE OF HUMAN PLACENTAL LACTOGEN. Placenta. A62-A62. 2012
- The generation of reactive oxygen and nitrogen species (RONS) is not different during injurious lengthening contractions and non-damaging isometric contractions. The FASEB Journal. 2012
- Maternal Undernutrition during Different Developmental Windows Is Associated with Altered Ovarian Core Clock Gene Transcription Factors and Impaired Follicle Growth.. Reproductive Sciences. 344A-344A. 2012
- Morphometric and immunohistochemical image analysis in pre-pubertal lamb testes after prenatal betamethasone treatment. COMPUTATIONAL VISION AND MEDICAL IMAGE PROCESSING: VIPIMAGE 2011. 123-129. 2012
- Perinatal Programming. PERINATAL PROGRAMMING: THE STATE OF THE ART. 59-67. 2011
- THE PREVALENCE AND METABOLIC SIGNIFICANCE OF NONALCOHOLIC FATTY LIVER DISEASE IN ADOLESCENT GIRLS WITH POLYCYSTIC OVARY SYNDROME. Hepatology. 1114A-1114A. 2011
- Do Humans Prioritize Protein Intake?. Journal of Developmental Origins of Health and Disease. S105-S105. 2011
- EARLY DEXAMETHASONE (DEX) EXPOSURE HAS LASTING EFFECTS ON GLUCOCORTICOID RECEPTOR ALPHA (GRA) IN SHEEP PLACENTOMES. Placenta. A72-A72. 2011
- Effects of Antenatal Betamethasone Treatment on Anthropometrics and Neonatal Outcome in Male Twins. Journal of Developmental Origins of Health and Disease. S61-S61. 2011
- Effects of Corticosteroid Treatment Either in Early or Late Pregnancy Restricts Brain Growth in Fetal and Postnatal-Age Sheep. Journal of Developmental Origins of Health and Disease. S90-S90. 2011
- Exploring the Potential of School Based Adolescent Intervention To Enable Translation of DOHaD Concepts into Community Understanding. Journal of Developmental Origins of Health and Disease. S26-S26. 2011
- Long Term Effects of Early Dexamethasone Treatment on Glucocorticoid Receptor Alpha and the Regulation of Binucleate Cell Function in Sheep Placenta. Journal of Developmental Origins of Health and Disease. S139-S139. 2011
- Maternal Fructose Intake Alters Hepatic Gene Expression and Leads to Changes in Glucose and Lipid Metabolism in Fetal and Neonatal Rat Offspring. Journal of Developmental Origins of Health and Disease. S11-S12. 2011
- Maternal Fructose Intake in the Rat Induces Changes in Placental Weight and Nutrient Transporter Levels. Journal of Developmental Origins of Health and Disease. S139-S140. 2011
- Maternal Nutritional Effects on Hypothalamic Regulation of Pubertal Onset and Appetite in Prepubertal Females. Journal of Developmental Origins of Health and Disease. S52-S52. 2011
- Ontogeny of Glucocorticoid Receptor Alpha Positive Stained Binucleate Cells in Sheep Placenta. Journal of Developmental Origins of Health and Disease. S139-S139. 2011
- Pilot Study: Maternal Betamethasone Administration Has Long Term Effects on Umbilical Cord Glucose Levels in Human Fetuses. Journal of Developmental Origins of Health and Disease. S86-S86. 2011
- Pre-Conceptional Maternal Nutrition Determines Levels of Key Pancreatic Genes in the Leptin Signalling Pathway. Journal of Developmental Origins of Health and Disease. S138-S138. 2011
- Prevalence and significance of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome. Journal of Gastroenterology and Hepatology. 53-53. 2011
- The Effect of Maternal Taurine Supplementation on Timing of Pubertal Onset in Male and Female Offspring Is Directionally Dependent upon Maternal Nutritional Background. Journal of Developmental Origins of Health and Disease. S29-S29. 2011
- Antenatal Betamethasone Treatment and Birth Weight Reduction - Possible Role of Human Placenta Lactogen in Females. Reproductive Sciences. 109A-109A. 2011
- Fructose Intake during Pregnancy in the Rat: Effects on Fetal and Placental Development. Reproductive Sciences. 220A-220A. 2011
- Nature or Nurture? Effects of Maternal High Fat Nutrition and Care on Offspring Reproductive, Metabolic and Stress Axis Function. Reproductive Sciences. 206A-206A. 2011
- The Effect of Betamethasone Treatment Late in Gestation in Sheep on the Appearance of Placentomes and Expression of Prostaglandin H Synthase Type 2 in Placentome Subtypes. Reproductive Sciences. 109A-109A. 2011
- The prevalence of features of the metabolic syndrome in girls with menstrual disturbance and PCOS in adolescence. Human Reproduction. I305-I306. 2010
- Feast or Famine: In the Fast Lane to Puberty. Journal of Perinatal Medicine. 2010
- Circulating Anti-Mullerian Hormone (AMH) Levels Are Significancly Associated with PCOS in Adolescence. Reproductive Sciences. 183A-183A. 2009
- Maternal Administration of Synthetic Glucocorticoids Significantly Alters Fetal Sheep Hypothalamic Gene Expression in a Site Specific Manner.. Reproductive Sciences. 357A-357A. 2009
- Maternal Androgen Levels at 18 and 36 Weeks Gestation, and Cord Androgen Levels Do Not Predict Finger Length Ratio (2D:4D) in Females. Reproductive Sciences. 327A-327A. 2009
- Maternal Androgen Levels at 18 and 36 Weeks Gestation, and Cord Androgen Levels Do Not Predict Polycystic Ovarian Syndrome in Adolescence. Reproductive Sciences. 184A-184A. 2009
- Maternal Free Testosterone Levels at 18 Weeks Gestation Predict Circulating Anti-Mullerian Hormone Levels in Adolescence. Reproductive Sciences. 82A-82A. 2009
- The Influence of Antenatal Growth Patterns and Maternal Smoking on Markers of Ovarian Reserve in Adolescence. Reproductive Sciences. 326A-326A. 2009
- Cortisol responses in young sheep after dexamethasone exposure in early gestation. Reproductive Sciences. 170A-170A. 2008
- Hippocampal corticosteroid receptors expression in young sheep: Effects of glucocorticoid exposure. Reproductive Sciences. 170A-170A. 2008
- Maternal glucocorticoid administration in early pregnancy and the relationship between 11 beta HSD2 mRNA in ovine placenta and fetal weight across gestation. Reproductive Sciences. 273A-273A. 2008
- Maternal glueocorticoid injections in early pregnancy altered the pituitary-adrenal axis in sheep. Reproductive Sciences. 169A-169A. 2008
- Adrenal gene expression in sheep is altered by maternal dexamethasone treatment in early gestation. Early Human Development. S102-S103. 2007
- Prenatal dexamethasone exposure results in gender-specific responses of the hypothalamic-pituitary-adrenal axis in lambs. Early Human Development. S102-S102. 2007
- 1D-5 Antenatal corticosteroids in late gestation reduce placental binucleate cells and placental and fetal oPL levels: potential contributors to fetal growth restriction in sheep. Early Human Development. S51-S51. 2007
- 2B-4 The effect of intrauterine exposure to maternal androgens on the incidence of Polycystic Ovarian Syndrome in a cohort of Australian adolescents The Raine cohort. Early Human Development. S54-S54. 2007
- 2B-6 Maternal high fat nutrition either pre-conceptionally and/or throughout pregnancy and lactation leads to early-onset puberty in offspring and is further exacerbated by a post-weaning high fat diet. Early Human Development. S54-S55. 2007
- 3E-6 Prenatal dexamethasone exposure in early gestation alters pituitary-adrenal responses to challenge in young sheep. Early Human Development. S64-S64. 2007
- Developmental changes in hippocampal corticosteroid receptors and 11 beta hydroxysteroid dehydrogenase in fetal sheep: effects of glucocorticoid exposure. Early Human Development. 545-545. 2006
- Developmental changes in ovine adrenal gene expression after exposure to prenatal betamethasone (BETA). Early Human Development. 544-544. 2006
- Differential effects of maternal betamethasone on ovine placental lactogen and binucleate cell number in sheep placentome subtypes. Early Human Development. 542-543. 2006
- Hippocampal gene expression is altered in adult sheep offspring after prenatal betamethasone exposure. Early Human Development. 545-546. 2006
- Influences of early maternal dexamethasone on fetal growth in sheep. Early Human Development. 543-543. 2006
- Age at menarche is related to birth weight and postnatal body mass index in a cohort of Australian adolescents. Human Reproduction. I109-I109. 2006
- Prenatal exposure to betamethasone modifies adrenal steroidogenic enzyme P450C(17) expression levels in sheep offspring.. Reproductive Sciences. 94A-94A. 2006
- Age at menarche is related to birthweight and postnatal BMI in a cohort of Australian adolescents. Pediatric Research. 1068-1068. 2005
- Alterations in factors regulating follicular development in sheep offspring exposed to prenatal betamethasone. Pediatric Research. 1057-1057. 2005
- Differential expression of the prostaglandin enzyme COX-2 is altered in late gestation sheep placentomes by administration of maternal betamethasone. Pediatric Research. 1061-1061. 2005
- Modulation of the ontogenic adrenal steroidodgenic capacity in the fetal sheep by maternal betamethasone administration in late gestation. Pediatric Research. 1053-1053. 2005
- The impact of maternal betamethasone administration on the feral ovine kidney. Pediatric Research. 1023-1023. 2005
- The polycystic ovary syndrome (PCOS) in adolescence and intrauterine exposure to maternal androgens. Pediatric Research. 1067-1068. 2005
- Nephron endowment in fetal sheep after repeated maternal glucocorticoid administration.. Reproductive Sciences. 243A-243A. 2005
- Ovine placental ontogeny and the effects of antenatal betametahsone administration.. Reproductive Sciences. 332A-332A. 2005
- Adult brain weight is reduced by antenatal betamethasone treatment in sheep.. Reproductive Sciences. 249A-249A. 2004
- The impact of prenatal maternal or fetal glucocorticoid administration on the adult ovine kidney.. Reproductive Sciences. 108A-108A. 2004
- Glucocorticoids and the fetal origins of adult disease. Pediatric Research. 6A-6A. 2003
- The evolution of postnatal hypothalamic-pituitary-adrenal (HPA) function in sheep after prenatal glucocorticoid administration. Pediatric Research. 40A-40A. 2003
- Feto-placental interactions and parturition. Journal of Physiology. 2S-2S. 2000
- Manometric characteristics of pharyngeal peristalsis in patients with chronic neurologic diseases.. Gastroenterology. A747-A747. 1998
-
journal articles
- Erasure of DNA methylation in rat fetal germ cells is sex-specific and sensitive to maternal high-fat diet.. Journal of Developmental Origins of Health and Disease. 15:e19. 2024
- High-fat, high-sucrose diet-induced obesity disrupts mid-gestational decidual inflammatory and vascular homeostasis without impairing spiral artery remodelling.. Placenta. 154:e76. 2024
- A Scoping Review of the Relationship Between Maternal BMI and Offspring Incidence of Respiratory Infection: Where Do We Go From Here?. AJPM Focus. 3:100234-100234. 2024
- Maternal high-fat diet during pregnancy and lactation affects factors that regulate cell proliferation and apoptosis in the testis of adult progeny. Reproduction, Fertility and Development. 36:RD23082. 2024
- Playing it safe? An evolutionary life history theory perspective on Canadian adolescent play during the COVID-19 pandemic. International Journal of Play. 13:254-276. 2024
- Parity modulates impact of BMI and gestational weight gain on gut microbiota in human pregnancy. Gut Microbes. 15:2259316. 2023
- Resilience in adolescence during the COVID-19 crisis in Canada. BMC Public Health. 23:1097. 2023
- Probiotics in pregnancy: Inequities in knowledge exchange, attitudes, and use of probiotics in a socio-demographically diverse, cross-sectional survey sample of pregnant Canadians. PharmaNutrition. 24:100344-100344. 2023
- Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor. American Journal of Physiology - Gastrointestinal and Liver Physiology. 324:G305-G321. 2023
- Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature. 613:639-649. 2023
- Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse. PLoS ONE. 18:e0284972-e0284972. 2023
- Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages in female mice independent of TNF 2022
- Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biology of Reproduction. 107:574-589. 2022
- Associations between exposure to adverse childhood experiences and biological aging: Evidence from the Canadian Longitudinal Study on Aging. Psychoneuroendocrinology. 142:105821-105821. 2022
- Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI). BMJ Open. 12:e059914-e059914. 2022
- Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium. Reproductive Sciences. 29:1136-1144. 2022
- Response to Letter to the editor on: “Never too late? Quadruplets at the age of 65 years”. Archives of Gynecology and Obstetrics. 305:1133-1134. 2022
- The intestine and the microbiota in maternal glucose homeostasis during pregnancy. Journal of Endocrinology. 253:R1-R19. 2022
- A10 EARLY LIFE SENSITIZATION TO GLUTEN INDUCES SUSTAINED IMMUNOPATHOLOGY IN DR3-DQ2 MICE. Journal of the Canadian Association of Gastroenterology. 5:11-13. 2022
- Reply to: “Hysterectomy versus continuing conservative management: which is better for disseminated intravascular coagulation?”; Shinya Matsuzaki, MD, PhD, Yoshikazu Nagase, MD, Masayuki Endo, MD, PhD, Tadashi Kimura, MD, PhD. Archives of Gynecology and Obstetrics. 305:539-541. 2022
- Dosage escalation of antenatal steroids in preterm twin pregnancies does not improve long-term outcome. Journal of Perinatal Medicine. 50:25-33. 2022
- Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging. Gerontology. 68:1091-1100. 2022
- Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice. Molecular Metabolism. 55:101404-101404. 2022
- The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells. Cells. 10:3515-3515. 2021
- Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation. Clinical Epigenetics. 13:165. 2021
- Over-celling fetal microbial exposure. Cell. 184:5839-5841. 2021
- Never too late? Quadruplets at the age of 65 years. Archives of Gynecology and Obstetrics. 304:851-854. 2021
- Online survey on uterotomy closure techniques in caesarean section. Journal of Perinatal Medicine. 49:809-817. 2021
- Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice 2021
- Fetal meconium does not have a detectable microbiota before birth. Nature Microbiology. 6:865-873. 2021
- Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics. 13:921-921. 2021
- Effects of Obesity-Associated Chronic Inflammation on Peripheral Blood Immunophenotype Are Not Mediated by TNF in Female C57BL/6J Mice. ImmunoHorizons. 5:370-383. 2021
- Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat. Reproduction, Fertility and Development. 33:484-496. 2021
- Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice. Journal of Physiology. 599:2169-2195. 2021
- A multicenter observational survey of management strategies in 442 pregnancies with suspected placenta accreta spectrum. Acta Obstetricia et Gynecologica Scandinavica. 100:12-20. 2021
- Association of peripartum management and high maternal blood loss at cesarean delivery for placenta accreta spectrum (PAS): A multinational database study. Acta Obstetricia et Gynecologica Scandinavica. 100:29-40. 2021
- Developing a database for multicenter evaluation of placenta accreta spectrum. Acta Obstetricia et Gynecologica Scandinavica. 100:7-11. 2021
- Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex‐specific manner. Journal of Physiology. 599:1487-1511. 2021
- Maternal and neonatal outcomes in planned versus emergency cesarean delivery for placenta accreta spectrum: A multinational database study. Acta Obstetricia et Gynecologica Scandinavica. 100:41-49. 2021
- Performance of antenatal imaging to predict placenta accreta spectrum degree of severity. Acta Obstetricia et Gynecologica Scandinavica. 100:21-28. 2021
- The relation between maternal obesity and placenta accreta spectrum: A multinational database study. Acta Obstetricia et Gynecologica Scandinavica. 100:50-57. 2021
- When a rare condition creates a scientific society: The history of the International Society for Placenta Accreta Spectrum (IS‐PAS). Acta Obstetricia et Gynecologica Scandinavica. 100:3-6. 2021
- Long term alterations of growth after antenatal steroids in preterm twin pregnancies. Journal of Perinatal Medicine. 49:127-137. 2021
- Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long-term effects of COVID-19. Journal of Developmental Origins of Health and Disease. 12:3-5. 2021
- RE: “INVITED COMMENTARY: THE DISILLUSIONMENT OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (DOHAD) EPIDEMIOLOGY”. American Journal of Epidemiology. 190:185-185. 2021
- Feasibility of Umbilical Cord Blood Collection in Neonates at Risk of Brain Damage—A Step Toward Autologous Cell Therapy for a High-risk Population. Cell Transplantation. 30:096368972199206-096368972199206. 2021
- Behaviour change interventions: getting in touch with individual differences, values and emotions. Journal of Developmental Origins of Health and Disease. 11:589-598. 2020
- Addressing embodied inequities in health: how do we enable improvement in women’s diet in pregnancy?. Public Health Nutrition. 23:2994-3004. 2020
- Maternal undernutrition during pregnancy and lactation affects testicular morphology, the stages of spermatogenic cycle, and the testicular IGF-I system in adult offspring. Journal of Developmental Origins of Health and Disease. 11:473-483. 2020
- Synergies between the Developmental Origins of Health and Disease framework and multiple branches of evolutionary anthropology. New Directions for Evaluation. 29:214-219. 2020
- Long-term effects of a maternal high-fat: high-fructose diet on offspring growth and metabolism and impact of maternal taurine supplementation. Journal of Developmental Origins of Health and Disease. 11:419-426. 2020
- Placental Metabolomics for Assessment of Sex-specific Differences in Fetal Development During Normal Gestation. Scientific Reports. 10:9399. 2020
- Knowledge about the Developmental Origins of Health and Disease is independently associated with variation in diet quality during pregnancy. Maternal and Child Nutrition. 16:e12891. 2020
- Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring. Reproductive Sciences. 26:1557-1567. 2019
- Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation. Scientific Reports. 9:17621. 2019
- Uterine packing with chitosan-covered gauze compared to balloon tamponade for managing postpartum hemorrhage. European Journal of Obstetrics & Gynecology and Reproductive Biology. 240:151-155. 2019
- Translating the Developmental Origins of Health and Disease concept to improve the nutritional environment for our next generations: a call for a reflexive, positive, multi-level approach. Journal of Developmental Origins of Health and Disease. 10:420-428. 2019
- Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?. Journal of Endocrinology. 242:T51-T68. 2019
- A proposal for standardized magnetic resonance imaging (MRI) descriptors of abnormally invasive placenta (AIP) – From the International Society for AIP. Journal de Radiologie diagnostique et interventionnelle. 100:319-325. 2019
- Evidence-based guidelines for the management of abnormally invasive placenta: recommendations from the International Society for Abnormally Invasive Placenta. American Journal of Obstetrics and Gynecology. 220:511-526. 2019
- High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers. Journal of Physiology. 597:3029-3051. 2019
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision. Journal of Perinatal Medicine. 47:12-15. 2018
- TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity‐induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice. Physiological Reports. 6:e13937-e13937. 2018
- Uterine scar thickness as an important outcome for the evaluation of up-to-date uterine closure techniques. American Journal of Obstetrics and Gynecology. 219:632-632. 2018
- Sex-specific and lasting effects of a single course of antenatal betamethasone treatment on human placental 11β-HSD2. Placenta. 69:9-19. 2018
- Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss†. Biology of Reproduction. 98:664-682. 2018
- Towards a Novel Patch Material for Cardiac Applications: Tissue-Specific Extracellular Matrix Introduces Essential Key Features to Decellularized Amniotic Membrane. International Journal of Molecular Sciences. 19:1032-1032. 2018
- Histomorphologic Analysis of the Late-term Rat Fetus and Placenta. Toxicologic Pathology. 46:158-168. 2018
- Revealing the action mechanisms of dexamethasone on the birth weight of infant using RNA-sequencing data of trophoblast cells. Medicine (United States). 97:e9653-e9653. 2018
- The murine female intestinal microbiota does not shift throughout the estrous cycle. PLoS ONE. 13:e0200729-e0200729. 2018
- Adolescents as agents of healthful change through scientific literacy development: A school-university partnership program in New Zealand. International Journal of STEM Education. 4:15. 2017
- Therapeutic Pelvic Lymph Node Dissection in the Second Gestational Trimester: A Case Report and Literature Review. Anticancer Research. 37:2487-2490. 2017
- Re: Prediction of delivery time in second stage of labor using transperineal ultrasound. Ultrasound in Obstetrics and Gynecology. 49:663-664. 2017
- Computed tomography and ultrasound to determine fetal head station. Ultrasound in Obstetrics and Gynecology. 49:279-280. 2017
- Fetal and Neonatal Outcomes After Term and Preterm Delivery After Betamethasone Administration in Twin Pregnancies. Obstetrical and Gynecological Survey. 72:80-81. 2017
- Prenatal decision-making in the second and third trimester in trisomy 21-affected pregnancies. Journal of Perinatal Medicine. 45:205-211. 2017
- Acephate exposure during a perinatal life program to type 2 diabetes. Toxicology. 372:12-21. 2016
- Re: Angle of fetal head progression measured using transperineal ultrasound as a predictive factor of vacuum extraction failure. Ultrasound in Obstetrics and Gynecology. 48:668-669. 2016
- Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration in twin pregnancies. International Journal of Gynecology and Obstetrics. 134:329-335. 2016
- In uterobetamethasone affects 3β-hydroxysteroid dehydrogenase and inhibin-α immunoexpression during testis development. Journal of Developmental Origins of Health and Disease. 7:342-349. 2016
- The importance of selecting the right internal control gene to study the effects of antenatal glucocorticoid administration in human placenta. Placenta. 44:19-22. 2016
- Fetal and Neonatal Outcomes After Term and Preterm Delivery Following Betamethasone Administration. Survey of Anesthesiology. 60:116-117. 2016
- Adverse metabolic phenotype of adolescent girls with non‐alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. Journal of Gastroenterology and Hepatology. 31:980-987. 2016
- Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring1. Biology of Reproduction. 94:94. 2016
-
Proposal for standardized ultrasound descriptors of abnormally invasive placenta (
AIP ). Ultrasound in Obstetrics and Gynecology. 47:271-275. 2016 - Perinatal programming of gut microbiota and immunity. Journal of Developmental Origins of Health and Disease. 7:2-4. 2016
- Perinatal programming of gut microbiota and immunity.. Journal of Developmental Origins of Health and Disease. 7:2-4. 2016
- The impact of early life gut colonization on metabolic and obesogenic outcomes: what have animal models shown us?. Journal of Developmental Origins of Health and Disease. 7:15-24. 2016
- Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats. Frontiers in Pharmacology. 7:48. 2016
- The dilution effect and the importance of selecting the right internal control genes for RT-qPCR: a paradigmatic approach in fetal sheep. BMC Research Notes. 8:58. 2015
- Glucocorticoid-Induced Preterm Birth and Neonatal Hyperglycemia Alter Ovine β-Cell Development. Molecular Endocrinology. 156:3763-3776. 2015
- Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring. Reproductive Sciences. 22:1297-1311. 2015
- Pregnancy-related changes in the maternal gut microbiota are dependent upon the mother's periconceptional diet. Gut Microbes. 6:310-320. 2015
- Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration. International Journal of Gynecology and Obstetrics. 130:64-69. 2015
- Effects of Maternal Dexamethasone Treatment Early in Pregnancy on Glucocorticoid Receptors in the Ovine Placenta. Reproductive Sciences. 22:534-544. 2015
- Early Life Exposure to Undernutrition Induces ER Stress, Apoptosis, and Reduced Vascularization in Ovaries of Adult Rat Offspring1. Biology of Reproduction. 92:110. 2015
- Periconceptual Programming of Transgenerational Disease Transmittance: When Does It All Begin?. Canadian Journal of Diabetes. 39:S2-S2. 2015
- Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring. Journal of Nutritional Biochemistry. 26:267-276. 2015
- Early-life nutritional effects on the female reproductive system. Journal of Endocrinology. 224:R45-R62. 2015
- Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation?. Journal of Perinatal Medicine. 43:503-523. 2015
- Early Dexamethasone Treatment Induces Placental Apoptosis in Sheep. Reproductive Sciences. 22:47-59. 2015
- Early Life Exposure to Fructose Alters Maternal, Fetal and Neonatal Hepatic Gene Expression and Leads to Sex-Dependent Changes in Lipid Metabolism in Rat Offspring. PLoS ONE. 10:e0141962-e0141962. 2015
- Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk. Pediatric Research. 77:196-204. 2015
- Re-analysis of the association between perinatal androgens and pragmatic language ability. Psychoneuroendocrinology. 49:32-33. 2014
- Re‐analysis of the association between perinatal androgens and postnatal head circumference growth. Developmental Medicine and Child Neurology. 56:1025-1025. 2014
- Maternal nutritional history modulates the hepatic IGF–IGFBP axis in adult male rat offspring. Endocrine. 46:70-82. 2014
- The influence of antenatal exposure to phthalates on subsequent female reproductive development in adolescence: a pilot study. Reproduction. 147:379-390. 2014
- Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis. Journal of Obesity. 2014:1-10. 2014
- Early-Life Glucocorticoid Exposure: The Hypothalamic-Pituitary-Adrenal Axis, Placental Function, and Long-term Disease Risk. Endocrine Reviews. 34:885-916. 2013
- Fructose, pregnancy and later life impacts. Clinical and Experimental Pharmacology and Physiology. 40:824-837. 2013
- Apoptosis‐Related Protein Expression During Pre‐ and Post‐Natal Testicular Development After Administration of Glucocorticoid in utero in the Sheep. Reproduction in Domestic Animals. 48:795-802. 2013
- Growth restricting effects of a single course of antenatal betamethasone treatment and the role of human placental lactogen. Placenta. 34:407-415. 2013
- Effects of glucocorticoid treatment given in early or late gestation on growth and development in sheep. Journal of Developmental Origins of Health and Disease. 4:146-156. 2013
- Prenatal diagnosis of abnormally invasive placenta reduces maternal peripartum hemorrhage and morbidity. Acta Obstetricia et Gynecologica Scandinavica. 92:439-444. 2013
- The impact of maternal synthetic glucocorticoid administration in late pregnancy on fetal and early neonatal hypothalamic–pituitary–adrenal axes regulatory genes is dependent upon dose and gestational age at exposure. Journal of Developmental Origins of Health and Disease. 4:77-89. 2013
- Effects of Taurine Supplementation on Hepatic Markers of Inflammation and Lipid Metabolism in Mothers and Offspring in the Setting of Maternal Obesity. PLoS ONE. 8:e76961-e76961. 2013
- Quantification of fetal head direction and descent. Ultrasound in Obstetrics and Gynecology. 41:99-100. 2013
- Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring: Same Metabolic Phenotype, Different Developmental Pathways?. Journal of Nutrition and Metabolism. 2013:1-11. 2013
- Adolescent understanding of DOHaD concepts: a school-based intervention to support knowledge translation and behaviour change. Journal of Developmental Origins of Health and Disease. 3:469-482. 2012
- Leptin as mediator of the effects of developmental programming. Best Practice and Research in Clinical Endocrinology and Metabolism. 26:677-687. 2012
- Testing the Protein Leverage Hypothesis in a free-living human population. Appetite. 59:312-315. 2012
- Abnormal vascular architecture at the placental-maternal interface in placenta increta. American Journal of Obstetrics and Gynecology. 207:188.e1-188.e9. 2012
- Maternal undernutrition during critical windows of development results in differential and sex-specific effects on postnatal adiposity and related metabolic profiles in adult rat offspring. British Journal of Nutrition. 108:298-307. 2012
- Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function. Journal of Physiology. 590:2167-2180. 2012
- The Effects of Dexamethasone Treatment in Early Gestation on Hypothalamic–Pituitary–Adrenal Responses and Gene Expression at 7 Months of Postnatal Age in Sheep. Reproductive Sciences. 19:260-270. 2012
- Developmental Origins of Health and Disease. Journal of Nutrition and Metabolism. 2012:1-2. 2012
- Strategies for Reversing the Effects of Metabolic Disorders Induced as a Consequence of Developmental Programming. Frontiers in Physiology. 3:242. 2012
- The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet. Journal of Nutrition and Metabolism. 2012:1-10. 2012
- Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range. BMC Genomics. 12:509. 2011
- Brief Report: Autistic-Like Traits in Childhood Predict Later Age at Menarche in Girls. Journal of Autism and Developmental Disorders. 41:1125-1130. 2011
- Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. Human Reproduction. 26:1469-1477. 2011
- Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome. Revista Iberoamericana de Fertilidad y Reproduccion Humana. 28:12. 2011
- Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome. Fertility and Sterility. 95:2347-2353.e1. 2011
- Differential appearance of placentomes and expression of prostaglandin H synthase type 2 in placentome subtypes after betamethasone treatment of sheep late in gestation. Placenta. 32:295-303. 2011
- Maternal Fructose Intake during Pregnancy and Lactation Alters Placental Growth and Leads to Sex-Specific Changes in Fetal and Neonatal Endocrine Function. Molecular Endocrinology. 152:1378-1387. 2011
- Maternal Fructose Intake during Pregnancy and Lactation Alters Placental Growth and Leads to Sex-Specific Changes in Fetal and Neonatal Endocrine Function. Journal of Clinical Endocrinology and Metabolism (JCEM). 96:871-871. 2011
- Reproduction in females: the role of the early life environment. Human Reproduction Update. 17:210-227. 2011
- A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone, but not placental labyrinth zone growth. Journal of Developmental Origins of Health and Disease. 2:63-70. 2011
- A study of progress of labour using intrapartum translabial ultrasound, assessing head station, direction, and angle of descent. BJOG: An International Journal of Obstetrics and Gynaecology. 118:62-69. 2011
- Maternal Obesity and Developmental Programming of Metabolic Disorders in Offspring: Evidence from Animal Models. Journal of Diabetes Research. 2011:1-9. 2011
- Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation. PLoS ONE. 6:e21662-e21662. 2011
- Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring. PLoS ONE. 5:e15558-e15558. 2010
- Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study. Fertility and Sterility. 94:1544-1547. 2010
- Fetal androgen exposure and pragmatic language ability of girls in middle childhood: Implications for the extreme male-brain theory of autism. Psychoneuroendocrinology. 35:1259-1264. 2010
- Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: A prospective cohort study. Psychoneuroendocrinology. 35:1235-1244. 2010
- Maternal high fat diet during critical windows of development alters adrenal cortical and medullary enzyme expression in adult male rat offspring. Journal of Developmental Origins of Health and Disease. 1:245-254. 2010
- Serum antimullerian hormone (AMH) levels are elevated in adolescent girls with polycystic ovaries and the polycystic ovarian syndrome (PCOS). Fertility and Sterility. 94:1118-1121. 2010
- Free testosterone levels in umbilical‐cord blood predict infant head circumference in females. Developmental Medicine and Child Neurology. 52:e73-e77. 2010
- Mirror Syndrome: A Systematic Review of Fetal Associated Conditions, Maternal Presentation and Perinatal Outcome. Fetal Diagnosis and Therapy. 27:191-203. 2010
- Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep. Molecular Endocrinology. 150:5466-5477. 2009
- Prenatal Determinants of Uterine Volume and Ovarian Reserve in Adolescence. Journal of Clinical Endocrinology and Metabolism (JCEM). 94:4931-4937. 2009
- Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep. Journal of Clinical Endocrinology and Metabolism (JCEM). 94:4625-4625. 2009
- The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study. Journal of Clinical Endocrinology and Metabolism (JCEM). 94:3714-3720. 2009
- Pre- and Postnatal Nutritional Histories Influence Reproductive Maturation and Ovarian Function in the Rat. PLoS ONE. 4:e6744-e6744. 2009
- Pilotstudie–Effekte der einmaligen Lungenreifeinduktion auf das fetale Wachstum. Zeitschrift für Geburtshilfe und Neonatologie. 213. 2009
- Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. Journal of Physiology. 587:905-915. 2009
- Impaired Perinatal Growth and Longevity: A Life History Perspective. Current Gerontology and Geriatrics Research. 2009:1-6. 2009
- Effects of Pre‐natal Glucocorticoids on Testicular Development in Sheep. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia. 37:352-358. 2008
- Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny. American Journal of Physiology - Endocrinology and Metabolism. 295:E170-E178. 2008
- Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11β-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure. Journal of Endocrinology. 197:213-220. 2008
- Why does menopausal hormone therapy lead to irregular uterine bleeding? Changes to endometrial blood vessels. Human Reproduction. 23:912-918. 2008
- The carotid bodies influence growth responses to moderate maternal undernutrition in late‐gestation fetal sheep. BJOG: An International Journal of Obstetrics and Gynaecology. 115:261-268. 2008
- 4A-6 Early-onset puberty in offspring after maternal undernutrition is exaggerated by a post-weaning high fat diet: sex specific evidence of nutritional mismatch. Early Human Development. 83:S65-S66. 2007
- Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep. Journal of Endocrinology. 194:337-347. 2007
- Age at Menarche: Influences of Prenatal and Postnatal Growth. Journal of Clinical Endocrinology and Metabolism (JCEM). 92:46-50. 2007
- Maternale Glukokortikoid Therapie und IUGR – mögliche Ursachen. Zeitschrift für Geburtshilfe und Neonatologie. 211. 2007
- Prenatal betamethasone exposure results in pituitary-adrenal hyporesponsiveness in adult sheep. American Journal of Physiology - Endocrinology and Metabolism. 292:E61-E70. 2007
- Hepatic glucose regulation and metabolism in adult sheep: effects of prenatal betamethasone. American Journal of Physiology - Endocrinology and Metabolism. 289:E721-E728. 2005
- Synthetic Glucocorticoids: Antenatal Administration and Long-term Implications. Current Pharmaceutical Design. 11:1459-1472. 2005
- 007.Recent advances in understanding and preventing pre-term birth - the oral health connection. Reproduction, Fertility and Development. 17:64-64. 2005
- Effects into adulthood of single or repeated antenatal corticosteroids in sheep. American Journal of Obstetrics and Gynecology. 192:146-152. 2005
- Using WinBUGS to Fit Nonlinear Mixed Models with an Application to Pharmacokinetic Modelling of Insulin Response to Glucose Challenge in Sheep Exposed Antenatally to Glucocorticoids. Journal of Biopharmaceutical Statistics. 13:117-139. 2003
- Antenatal corticosteroids: the good, the bad and the unknown. Current Opinion in Obstetrics and Gynecology. 14:607-612. 2002
- Nutrition and the early origins of adult disease. Asia Pacific Journal of Clinical Nutrition. 11:S537-S542. 2002
- Repeated maternal glucocorticoid administration and the developing liver in fetal sheep. Journal of Endocrinology. 175:535-543. 2002
- Prostaglandins and mechanisms of preterm birth. Reproduction. 124:1-17. 2002
- The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function. Journal of Endocrinology. 172:71-81. 2002
- The fetal placental hypothalamic–pituitary–adrenal (HPA) axis, parturition and post natal health. Molecular and Cellular Endocrinology. 185:135-144. 2001
- Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 281:R960-R970. 2001
- Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term. Journal of Endocrinology. 165:79-91. 2000
- Fetal Hypothalamic-Pituitary Adrenal (HPA) Development and Activation as a Determinant of the Timing of Birth, and of Postnatal Disease. Endocrine Research. 26:489-504. 2000
- Regulation of corticosteroids in the fetus: control of birth and influence on adult disease. Seminars in Fetal and Neonatal Medicine. 4:93-97. 1999
- 2017 International Women's and Children's Health Conference Abstracts. The Meducator. 1:9-9.
- Dosisabhängige Beeinträchtigung des Fetalwachstums nach antenataler Lungenreifeinduktion mit Betamethason bei Zwillingen. Zeitschrift für Geburtshilfe und Neonatologie. 217.
- Lungenreifeinduktion mit Betamethason – Effekte auf das fetale Wachstum und die Glukosehomöostase. Zeitschrift für Geburtshilfe und Neonatologie. 217.
- Prenatal nutritional influences on obesity risk in offspring. Nutrition and Dietary Supplements. Volume 2:137-137.
- Racism and Pregnancy Health in Hamilton, Ontario. Canadian Journal of Midwifery Research and Practice. 22.
- Untersuchungen zu den Effekten der antenatale Lungenreifeinduktion mit Betamethason auf die maternalen und fetalen ACTH- und Cortisol-Spiegel. Zeitschrift für Geburtshilfe und Neonatologie. 217.
- Validierung von Housekeeping Genen für Genexpressionsanalysen im fetalen Gewebe. Zeitschrift für Geburtshilfe und Neonatologie. 217.
-
preprints
- Maternal obesogenic diet disrupts mid-gestation decidual immune and vascular homeostasis without impairing spiral artery remodelling 2024
- Maternal adaptations in mouse lactation are vulnerable to diet-induced excess adiposity 2023
- Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy 2022
- Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition 2022
- Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse 2022
- Paternal obesity results in placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolic function 2021
- Fetal gut colonization: meconium does not have a detectable microbiota before birth 2021
- High-fat diet intake modulates maternal intestinal adaptations to pregnancy, and results in placental hypoxia and impaired fetal gut development 2018
- Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation
-
presentations
- The Art of Creation: An Art-Based Approach to Promote and Advocate for a Healthy Start to Life 2022
- Food Insecurity, Pregnancy Complications, and the Developmental Origins of Health and Disease: New Insights from the Mothers to Babies (M2B) Hamilton Study 2018
- The Knowledge Translation (KT) of Nutritional Health Information during Pregnancy: A Case Study form the Mothers to Babies (M2B) Project 2016