Journal article
Why does menopausal hormone therapy lead to irregular uterine bleeding? Changes to endometrial blood vessels
Abstract
BACKGROUND: Abnormal bleeding is common in hormone therapy (HT) users. We aimed to determine how HT alters endometrial blood vessels and stromal factors known to regulate vascular growth and integrity.
METHODS: Prospective observational study of 165 post-menopausal women in Western Australia. The following were measured in endometrial biopsies: vascular density (vessels/mm(2)), total vessel area (total area enclosed by peripheral vascular …
Authors
Hickey M; Doherty DA; Fraser IS; Sloboda DM; Salamonsen LA
Journal
Human Reproduction, Vol. 23, No. 4, pp. 912–918
Publisher
Oxford University Press (OUP)
Publication Date
4 2008
DOI
10.1093/humrep/dem418
ISSN
0268-1161
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAustraliaBiopsy, NeedleEndometriumFemaleGene ExpressionHormone Replacement TherapyHumansMatrix Metalloproteinase 1Matrix Metalloproteinase 14Matrix Metalloproteinase 3Matrix Metalloproteinase 9MetrorrhagiaMiddle AgedPostmenopauseProspective StudiesTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of MetalloproteinasesVascular Endothelial Growth Factor ATissue Inhibitor of Metalloproteinase-4