Journal article
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor
Abstract
Macrophages are essential for homeostatic maintenance of the anti-inflammatory and tolerogenic intestinal environment, yet monocyte-derived macrophages can promote local inflammation. Proinflammatory macrophage accumulation within the intestines may contribute to the development of systemic chronic inflammation and immunometabolic dysfunction in obesity. Using a model of high-fat diet-induced obesity in C57BL/6J female mice, we assessed …
Authors
Breznik JA; Jury J; Verdú EF; Sloboda DM; Bowdish DME
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 324, No. 4, pp. g305–g321
Publisher
American Physiological Society
Publication Date
April 1, 2023
DOI
10.1152/ajpgi.00231.2022
ISSN
0193-1857