Journal article
Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure
Abstract
Our aim was to determine the postnatal effects of single and repeated glucocorticoid injections during late gestation. Repeated (104, 111, 118, 125 days) or single (104 days) injections of betamethasone or saline were given to the ewe or by ultrasound guided injection to the fetus (term 150 days). Lambs were born spontaneously and studied at 3 and 6 mo and 1 yr of age. Arterial pressure was measured at each age, and we performed intravenous …
Authors
Moss TJM; Sloboda DM; Gurrin LC; Harding R; Challis JRG; Newnham JP
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 281, No. 3, pp. r960–r970
Publisher
American Physiological Society
Publication Date
September 1, 2001
DOI
10.1152/ajpregu.2001.281.3.r960
ISSN
0363-6119