Programming Effects of Excess Glucocorticoid Exposure in Late Gestation

Glucocorticoids are powerful hormones that play a crucial role in normal maturation of fetal organs in preparation for life outside the womb. However, exposure of the fetus to elevated levels of glucocorticoids, or exposure at inappropriate times, subtly disturbs normal fetal development. Experimental studies have demonstrated that late gestational exposure to excess glucocorticoids causes programming of a number of organ systems.