Journal article
Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep
Abstract
Fetal exposure to elevated levels of bioactive glucocorticoids early in gestation, as in suspected cases of congenital adrenal hyperplasia, may result in adverse neurological events. Fetal hypothalamic-pituitary-adrenal development and function may be involved. We investigated immediate and long-term effects of maternal dexamethasone (DEX) administration early in pregnancy on fetal growth and pituitary-adrenal activity in sheep. Pregnant ewes …
Authors
Braun T; Li S; Sloboda DM; Li W; Audette MC; Moss TJM; Matthews SG; Polglase G; Nitsos I; Newnham JP
Journal
The Journal of Clinical Endocrinology & Metabolism, Vol. 94, No. 11, pp. 4625–4625
Publisher
The Endocrine Society
Publication Date
November 1, 2009
DOI
10.1210/jcem.94.11.9996
ISSN
0021-972X