Experts has a new look! Let us know what you think of the updates.

Provide feedback
Home
Scholarly Works
Effects of Maternal Dexamethasone Treatment in...
Journal article

Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep

Abstract

Fetal exposure to elevated levels of bioactive glucocorticoids early in gestation, as in suspected cases of congenital adrenal hyperplasia, may result in adverse neurological events. Fetal hypothalamic-pituitary-adrenal development and function may be involved. We investigated immediate and long-term effects of maternal dexamethasone (DEX) administration early in pregnancy on fetal growth and pituitary-adrenal activity in sheep. Pregnant ewes …

Authors

Braun T; Li S; Sloboda DM; Li W; Audette MC; Moss TJM; Matthews SG; Polglase G; Nitsos I; Newnham JP

Journal

The Journal of Clinical Endocrinology & Metabolism, Vol. 94, No. 11, pp. 4625–4625

Publisher

The Endocrine Society

Publication Date

November 1, 2009

DOI

10.1210/jcem.94.11.9996

ISSN

0021-972X