Never too late? Quadruplets at the age of 65 years Academic Article uri icon

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  • Abstract Background We discuss the challenges of multiple pregnancy at very advanced reproductive age. Case presentation We present the case of a quadruplet pregnancy at the maternal age of 65 following in-vitro fertilization (IVF) with donor eggs and sperm, involving cross-border reproductive care. All children born were at 25 weeks’ gestation and survived; however, poor neurodevelopmental outcome remains a major concern in one child. Conclusions The use of reproductive technology to achieve a multiple pregnancy at such an advanced post-menopausal age generated a debate on ethical, psychosocial and medical questions. We share this debate and highlight the need to reconsider international guidelines for women of advanced reproductive age.


  • Sloboda, Deborah
  • Hinkson, Larry
  • Dame, Christof
  • Braun, Thorsten
  • Nachtigall, Irit
  • Henrich, Wolfgang

publication date

  • October 2021

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