RNA Interference Concept

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• Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules ofDrosophila melanogaster  Journal Articles
• Caenorhabditis elegansHistone Deacetylasehda-1Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates  Journal Articles
• Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis  Journal Articles
• A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations  Journal Articles
• Activin A Promotes Hematopoietic Fated Mesoderm Development Through Upregulation of Brachyury in Human Embryonic Stem Cells  Journal Articles
• Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy  Journal Articles
• An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity  Journal Articles
• BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis  Journal Articles
• Behavioral effects of non-viral mediated RNA interference of synapsin II in the medial prefrontal cortex of the rat  Journal Articles
• Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation  Journal Articles
• CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection  Journal Articles
• COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux  Journal Articles
• Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β  Journal Articles
• Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53  Journal Articles
• Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells  Journal Articles
• Comparative analysis of function and interaction of transcription factors in nematodes: Extensive conservation of orthology coupled to rapid sequence evolution  Journal Articles
• Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy  Journal Articles
• Control of Centromere Localization of the MEI-S332 Cohesion Protection Protein  Journal Articles
• Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3  Journal Articles
• Deciphering brain tumor heterogeneity, one cell at a time  Journal Articles
• Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells  Journal Articles
• Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells  Journal Articles
• Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells  Journal Articles
• Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development  Journal Articles
• EB1 Levels Are Elevated in Ascorbic Acid (AA)-stimulated Osteoblasts and Mediate Cell-Cell Adhesion-induced Osteoblast Differentiation  Journal Articles
• EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells  Journal Articles
• ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation  Journal Articles
• Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress  Journal Articles
• Fc Gamma Receptor Signaling in Mast Cells Links Microbial Stimulation to Mucosal Immune Inflammation in the Intestine  Journal Articles
• Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease  Journal Articles
• Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network  Journal Articles
• Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins  Journal Articles
• Genetic Changes Accompanying the Evolution of Host Specialization in Drosophila sechellia  Journal Articles
• Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response  Journal Articles
• IQGAP2, A candidate tumour suppressor of prostate tumorigenesis  Journal Articles
• Identification and functional analyses of sex determination genes in the sexually dimorphic stag beetle Cyclommatus metallifer  Journal Articles
• Identification of likely orthologs of tobacco salicylic acid‐binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana  Journal Articles
• Induction of HIF-2α is dependent on mitochondrial O₂ consumption in an O₂-sensitive adrenomedullary chromaffin cell line  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response  Journal Articles
• Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained  Journal Articles
• Lossless Compression of RNAi Fluorescence Images Using Regional Fluctuations of Pixels  Journal Articles
• Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development  Journal Articles
• Menin Is a Regulator of the Stress Response in Drosophila melanogaster  Journal Articles
• Menin Links the Stress Response to Genome Stability in Drosophila melanogaster  Journal Articles
• MiR-204 down-regulation elicited perturbation of a gene target signature common to human cholangiocarcinoma and gastric cancer  Journal Articles
• Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop  Journal Articles
• Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming  Journal Articles
• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways  Journal Articles
• PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Proteins Required for Centrosome Clustering in Cancer Cells  Journal Articles
• RNA Interference inCaenorhabditis elegans  Journal Articles
• RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity  Journal Articles
• RNAi screen identifies essential regulators of human brain metastasis-initiating cells  Journal Articles
• Requirement and Redundancy of the Src Family Kinases Fyn and Lyn in Perforin-Dependent Killing of Cryptococcus neoformans by NK Cells  Journal Articles
• Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.  Journal Articles
• Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression  Journal Articles
• Role of PRY-1/Axin in heterochronic miRNA-mediated seam cell development  Journal Articles
• Sam68 Allows Selective Targeting of Human Cancer Stem Cells  Journal Articles
• Secondary-Structure Characterization of Two Proficient Kinase Deoxyribozymes  Journal Articles
• Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits  Journal Articles
• Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer  Journal Articles
• Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics  Journal Articles
• The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin  Journal Articles
• The small heat‐shock protein αB‐crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis  Journal Articles
• Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling  Journal Articles
• Thrombospondin‐1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor‐related protein‐1 (LRP‐1)  Journal Articles
• Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo  Journal Articles
• VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection  Journal Articles
• Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers  Journal Articles
• p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor  Journal Articles
• p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade  Journal Articles
• α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells  Journal Articles