Journal article
VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection
Abstract
Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VEGF-mediated suppression of the intrinsic antiviral response. VEGF/VEGFR2 signaling through Erk1/2 and Stat3 leads to upregulation, nuclear localization, and activation of the transcription repressor …
Authors
Arulanandam R; Batenchuk C; Angarita FA; Ottolino-Perry K; Cousineau S; Mottashed A; Burgess E; Falls TJ; De Silva N; Tsang J
Journal
Cancer Cell, Vol. 28, No. 2, pp. 210–224
Publisher
Elsevier
Publication Date
August 2015
DOI
10.1016/j.ccell.2015.06.009
ISSN
1535-6108
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell LineCell Line, TumorCells, CulturedGene ExpressionGene Expression ProfilingHost-Pathogen InteractionsHuman Umbilical Vein Endothelial CellsHumansMice, Inbred C57BLMicroscopy, FluorescenceNeoplasmsNeovascularization, PathologicOncolytic VirusesPositive Regulatory Domain I-Binding Factor 1RNA InterferenceReceptors, Vascular Endothelial Growth FactorRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionTranscription FactorsTranscriptional ActivationVaccinia virusVascular Endothelial Growth Factor A