Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β Journal Articles

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abstract

Adhesion with macrophages promotes the activation of fibroblasts into myofibroblasts and creates a self-sustaining profibrotic niche.

authors

Lodyga, Monika
Cambridge, Elizabeth
Karvonen, Henna M
Pakshir, Pardis
Wu, Brian
Boo, Stellar
Kiebalo, Melanie
Kaarteenaho, Riitta
Glogauer, Michael
Kapoor, Mohit
Ask, Kjetil
Hinz, Boris

status

published

publication date

January 15, 2019

has subject area

0601 Biochemistry and Cell Biology (FoR)
Animals (MeSH)
Cadherins (MeSH)
Cell Adhesion (MeSH)
Cells, Cultured (MeSH)
Coculture Techniques (MeSH)
Fibroblasts (MeSH)
Fibrosis (MeSH)
Humans (MeSH)
Macrophages (MeSH)
Male (MeSH)
Mice, Inbred C57BL (MeSH)
Microscopy, Electron (MeSH)
Myofibroblasts (MeSH)
Protein Binding (MeSH)
RNA Interference (MeSH)
Signal Transduction (MeSH)
Transforming Growth Factor beta (MeSH)

published in

Science Signaling Journal